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Zolmitriptan Prescription
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Generic Name: zolmitriptan (oral) (ZOLE mi TRIP tan)
Brand Name: Zomig, Zomig-ZMT
Physician reviewed zolmitriptan (oral) patient information - includes zolmitriptan description, dosage and directions. Average Savings for zolmitriptan (generic): 76.48%
Generic Name: zolmitriptan (oral) (ZOLE mi TRIP tan)
Brand Name: Zomig, Zomig-ZMT
Physician reviewed zolmitriptan (oral) patient information - includes zolmitriptan description, dosage and directions. Average Savings for zolmitriptan (generic): 76.48%
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30 tablets of Zolmitriptan 40 mg
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Zolmitriptan Drug Information:

Zolmitriptan is a headache medicine that narrows blood vessels around the brain. Zolmitriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Zolmitriptan is used to treat migraine headaches in adults. Zolmitriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks. Zolmitriptan should not be used to treat a common tension headache, a headache that causes loss of movement on one side of your body, or any headache that seems to be different from your usual migraine headaches. Use this medication only if your condition has been cOnfirmed by a doctor as migraine headaches. Learn more

Zolmitriptan Side Effects

In Summary

Commonly reported side effects of zolmitriptan include: dysgeusia. Other side effects include: dizziness, drowsiness, hyperesthesia, jaw pain, nausea, neck pain, paresthesia, sore throat, flushing sensation, local pain, and sensation of cold. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to zolmitriptan: oral tablet, oral tablet disintegrating

Other dosage forms:

  • nasal spray

Along with its needed effects, zolmitriptan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking zolmitriptan:

More common

  • Chest pain (severe)
  • heaviness, tightness, or pressure in the chest or neck
  • sensation of burning, warmth, heat, numbness, tightness, or tingling

Less common or rare

  • Abdominal or stomach pain (severe)
  • changes in facial skin color
  • cough or hoarseness
  • diarrhea
  • fast or irregular heartbeat
  • fever or chills
  • hives, itching, or skin rash
  • itching
  • loss of appetite
  • lower back or side pain
  • nausea
  • painful or difficult urination
  • puffiness or swelling of the eyelids or around the eyes, face, or lips
  • tightness in the chest
  • trouble breathing
  • weakness


  • Blurred vision
  • confusion
  • difficulty swallowing
  • dizziness
  • fainting
  • frequent strong or increased urge to urinate
  • headache
  • increased volume of pale, dilute urine
  • nervousness
  • pounding in the ears
  • severe numbness, especially on one side of the face or body
  • slow heartbeat
  • unusual tiredness or weakness

Incidence not known

  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Some side effects of zolmitriptan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Lack or loss of strength
  • sleepiness or unusual drowsiness
  • warm or cold sensation

Less common

  • Dizziness or lightheadedness
  • dry mouth
  • feeling of constant movement of self or surroundings
  • sensation of spinning


  • Anxiety
  • crying
  • depersonalization
  • depression
  • dysphoria
  • euphoria
  • hyperventilation
  • irritability
  • loss of memory
  • paranoia
  • problems with memory
  • quick to react or overreact emotionally
  • rapidly changing moods
  • redness of the skin
  • seeing, hearing, or feeling things that are not there
  • shaking
  • trouble sleeping
  • welts

For Healthcare Professionals

Applies to zolmitriptan: nasal spray, oral tablet, oral tablet disintegrating


Common (1% to 10%): Chest pain/tightness/pressure and/or heaviness, neck/throat/jaw pain/tightness/pressure, palpitations

Uncommon (0.1% to 1%): Arrhythmias, hypertension, syncope, tachycardia

Rare (less than 0.1%): Angina pectoris, myocardial infarct, coronary vasospasm, QT prolongation, thrombophlebitis

Rare reports of serious cardiac adverse events have been reported including acute myocardial infarction within a few hours following administration of this drug.

Chest pain/tightness/pressure and/or heaviness appear to be dose-related occurring in 2%, 3%, and 4% of patients receiving 1 mg, 2.5 mg, and 5 mg, respectively. Neck/throat/jaw pain/tightness/pressure occurred in 4%, 7%, and 10% of patients, respectively.

Nervous system

Very Common (greater than 10%): Taste disturbances (up to 21%, inhaler)

Common (1% to 10%): Paresthesia, somnolence, dizziness, hyperesthesia

Rare (less than 0.1%): Cerebral ischemia, amnesia, convulsions, ataxia, dystonia, hyperkinesia, hypotonia, hypertonia

Frequency not reported: Serotonin syndrome

Paresthesia appears to be a dose-related adverse event occurring in 5%, 7%, and 9% of patients receiving 1 mg, 2.5 mg, and 5 mg, respectively.


Common (1% to 10%): Warm/cold sensation, heaviness other than chest or neck, pressure/tightness/heaviness, vertigo, asthenia, chills

Uncommon (0.1% to 1%): Tinnitus, hyperacusis, ear pain


Common (1% to 10%): Nausea, dry mouth, dysphagia, dyspepsia, abdominal pain, vomiting

Uncommon (0.1% to 1%): Gastroenteritis, increased thirst

Rare (less than 0.1%): Stomatitis, constipation, hematemesis, pancreatitis, melena, ulcer

Very rare (less than 0.01%): Bloody diarrhea, gastrointestinal infarction or necrosis, gastrointestinal ischemic events, ischemic colitis, splenic infarction


The most common adverse reactions included neck, throat, jaw pain; dizziness; paresthesia; asthenia; somnolence; warm and cold sensation; nausea; heaviness sensation; and dry mouth. In adolescents treated with the nasal spray, the more commonly reported adverse reactions included dysgeusia, nasal discomfort, dizziness, oropharyngeal pain, and nausea.


Uncommon (0.1% to 1%): ecchymosis

Rare (less than 0.1%): Thrombocytopenia, eosinophilia, leucopenia


Uncommon (0.1% to 1%): Increased appetite, thirst

Rare (less than 0.1%): Anorexia, hyperglycemia


Common (1% to 10%): Arthralgia, myalgia, muscle weakness

Uncommon (0.1% to 1%): Back pain, leg cramps, tenosynovitis

Rare (less than 0.1%): Arthritis, tetanus, twitching


Common (1% to 10%): Disorder/discomfort of nasal cavity, throat pain, throat tightness, oropharyngeal pain

Uncommon (0.1% to 1%): Pharyngitis, rhinitis, dyspnea, sinusitis, bronchitis, increased cough, epistaxis, laryngeal edema, hiccup, laryngitis, yawn

Rare (less than 0.1%): Apnea, voice alteration


Uncommon (0.1% to 1%): Allergic reactions

Postmarketing reports: Hypersensitivity reactions including angioedema, anaphylactic reactions and anaphylactic shock


Rare (less than 0.1%): Diplopia, dry eyes, lacrimation, conjunctivitis, eye pain, visual field defect


Uncommon (0.1% to 1%): Polyuria, urinary urgency, cystitis, hematuria

Rare (less than 0.1%): Urinary frequency, miscarriage, dysmenorrhea


Common (1% to 10%): Sweating, facial edema

Uncommon (0.1% to 1%): Urticaria, pruritus, rash, photosensitivity reaction

Rare (less than 0.1%): Angioedema


Common (1% to 10%): Local irritation or soreness at the site of administration of nasal spray

In clinical trials using the nasal spray approximately 3% (n=460) patients reported local irritation or soreness at the site of administration. Effects were severe in about 1% of patients and approximately 57% resolved in 1 hour. Nasopharyngeal examinations of a subset of patients failed to demonstrate any clinically significant changes with repeated use of the nasal spray.

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Zolmitriptan (www.drugs.com/mtm/zolmitriptan.html).