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Zofran Prescription
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Generic Name: ondansetron (oral) (on DAN se tron)
Brand Names: Zofran, Zofran ODT, Zuplenz
Zofran (ondansetron) is used to prevent nausea and vomiting caused by surgery or cancer medicines. Includes Zofran side effects, interactions and indications. Average Savings for ondansetron hydrochloride (generic): 40.4%
Generic Name: ondansetron (oral) (on DAN se tron)
Brand Names: Zofran, Zofran ODT, Zuplenz
Zofran (ondansetron) is used to prevent nausea and vomiting caused by surgery or cancer medicines. Includes Zofran side effects, interactions and indications. Average Savings for ondansetron hydrochloride (generic): 40.4%
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30 tablets of Zofran 40 mg
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Zofran Drug Information:

Zofran (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting. Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment. Zofran may be used for purposes not listed in this medication guide. You should not use Zofran if you are also using apomorphine (Apokyn). You should not use Zofran if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Learn more

Zofran Side Effects

Note: This document contains side effect information about ondansetron. Some of the dosage forms listed on this page may not apply to the brand name Zofran.

For the Consumer

Applies to ondansetron: film, solution, tablet, tablet disintegrating

Other dosage forms:

  • injection solution

Along with its needed effects, ondansetron (the active ingredient contained in Zofran) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ondansetron:

More common

  • Confusion
  • dizziness
  • fast heartbeat
  • fever
  • headache
  • shortness of breath
  • weakness

Less common

  • Decrease in the frequency of urination
  • decrease in the urine volume
  • difficulty with passing urine (dribbling)
  • painful urination


  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • convulsions
  • cough
  • decreased urine
  • difficulty with breathing
  • difficulty with swallowing
  • dry mouth
  • fast, pounding, or irregular heartbeat or pulse
  • increased thirst
  • loss of appetite
  • loss of bladder control
  • loss of consciousness
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • noisy breathing
  • numbness or tingling in the hands, feet, or lips
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash, hives, or itching
  • sweating
  • tightness in the chest
  • total body jerking
  • unusual tiredness or weakness
  • wheezing

Incidence not known

  • Blurred vision
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fixed position of the eye
  • heart stops
  • hoarseness
  • inability to move the eyes
  • increased blinking or spasms of the eyelid
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • no breathing
  • no pulse or blood pressure
  • noisy breathing
  • pounding heartbeat
  • slow or irregular breathing
  • sticking out of the tongue
  • sweating
  • trouble with speaking
  • unconscious
  • uncontrolled twisting movements of the neck, trunk, arms, or legs
  • unusual facial expressions

Some side effects of ondansetron may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Anxiety
  • difficulty having a bowel movement (stool)
  • dry mouth
  • general feeling of discomfort or illness
  • hyperventilation
  • irritability
  • restlessness
  • shaking
  • trouble sleeping


  • Difficulty with speaking
  • drooling
  • loss of balance control
  • muscle trembling, jerking, or stiffness
  • shuffling walk
  • stiffness of the limbs
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back

Incidence not known

  • Feeling of warmth
  • hiccups
  • redness of the face, neck, arms, and occasionally, upper chest
  • redness of the skin
  • welts

For Healthcare Professionals

Applies to ondansetron: injectable solution, intravenous solution, oral disintegrating strip, oral solution, oral tablet, oral tablet disintegrating


The most frequently reported side effects are headache, constipation, and diarrhea.

Nervous system

Dizziness occurred during rapid IV administration.

Headache occurred more often in the oral dissolving tablet formulation when taken with water.

Very common (10% or more): Headache (up to 27%), drowsiness/sedation (up to 23%)

Common (1% to 10%): Dizziness, paresthesia

Uncommon (0.1% to 1%): Seizures, movement disorders/extrapyramidal reactions (oculogyric crisis/dystonic reactions, dyskinesia)

Rare (0.01% to 0.1%): Grand mal seizures


Wound problems occurred at the surgical site in patients given this drug for the treatment of postoperative nausea and vomiting.

Very common (10% or more): Wound problem (up to 28%), malaise/fatigue (up to 13%)

Common (1% to 10%): Shivers, pyrexia/fever, cold sensation

Frequency not reported: Pain, ear disorder


Localized anal/rectal burning occurred after insertion of the suppository formulation.

Very common (10% or more): Diarrhea (up to 16%), constipation (up to 11%)

Common (1% to 10%): Xerostomia, nausea, vomiting, localized anal/rectal burning sensation

Uncommon (0.1% to 1%): Throat disorder

Frequency not reported: Gastric symptoms, abdominal pain, flatulence


Very common (10% or more): Eye disorder (up to 19%)

Common (1% to 10%): Visual disturbance/transient visual disturbances (e.g., blurred vision)

Uncommon (0.1% to 1%): Oculogyric crisis

Very rare (less than 0.01%): Transient blindness

Frequency not reported: Swollen periocular area

Oculogyric crisis occurred alone and in combination with other dystonic reactions.

Transient visual disturbances, blurred vision, and transient blindness occurred predominantly during rapid IV administration. Many of the cases of blindness resolved from within a few minutes to approximately 28 hours. Most patients were receiving concomitant chemotherapy with cisplatin.


Cardiopulmonary arrest and shock occurred during allergic reactions in patients given the IV formulation.

Common (1% to 10%): Sensation of warmth/flushing, bradycardia, hypotension, arrhythmias

Uncommon (0.1% to 1%): Chest pain with/without ST segment depression

Rare (0.01% to 0.1%): Transient ECG changes including QT interval prolongation (Torsade de Pointes), angina/chest pain, vascular occlusive events, tachycardia

Frequency not reported: Hemorrhage

Postmarketing reports: Cardiopulmonary arrest, shock


Common (1% to 10%): Hypoxia, lower respiratory tract disease, expectoration, cough

Uncommon (0.1% to 1%): Hiccups

Rare (0.01% to 0.1%): Bronchospasm/asthma

Postmarketing reports: Shortness of breath, laryngeal edema, stridor, laryngospasm

Laryngospasm occurred during allergic reactions in patients given the IV formulation.


Common (1% to 10%): Anxiety/agitation, disturbance in behavior/conduct, sleep disturbance


Common (1% to 10%): Gynecological disorder, urinary retention, urinary tract infection/dysuria


Common (1% to 10%): Rash, pruritus

Very rare (less than 0.01%): Toxic skin eruption, toxic epidermal necrolysis


Transient, asymptomatic increases in AST/ALT 2 times the upper limit of normal commonly occurred in patients receiving chemotherapy with cisplatin, and did not appear to be related to dose/duration of treatment.

Liver failure and death have been reported in patients with cancer receiving potentially hepatotoxic/cytotoxic chemotherapy and antibiotics; however, the etiology of liver failure is unknown.

Common (1% to 10%): Asymptomatic increases in AST/ALT

Postmarketing reports: Liver failure and death


Common (1% to 10%): Injection site reactions


Rare (0.01% to 0.1%): Immediate hypersensitivity reactions (sometimes severe), anaphylaxis/anaphylactoid reactions

Postmarketing reports: Angioedema


Rare (0.01% to 0.1%): Hypokalemia

Frequency not reported: Poor oral intake

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Zofran (www.drugs.com/zofran.html).