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Zestoretic Prescription
Generic Name: hydrochlorothiazide and lisinopril (HYE droe KLOR oh THYE a zide and lye SIN oh pril)
Brand Names: Zestoretic
Zestoretic (hydrochlorothiazide and lisinopril) is used to treat high blood pressure. Includes Zestoretic side effects, interactions and indications.

Average Savings for lisinopril/hydrochlorothi (generic): 35.07%
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Zestoretic Drug Information:

Zestoretic contains a combination of hydroChlorothiazide and Lisinopril. HydroChlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Lisinopril is in an ACE inhibitor. ACE stands for angiotensin converting enzyme. Lisinopril lowers blood pressure and also relieves symptoms of fluid retention. Zestoretic is used to treat hypertension (high blood pressure). Zestoretic may also be used for purposes not listed in this medication guide. Learn more

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Zestoretic Side Effects

Note: This document contains side effect information about hydrochlorothiazide / lisinopril. Some of the dosage forms listed on this page may not apply to the brand name Zestoretic.

In Summary

More frequent side effects include: dizziness and headache. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to hydrochlorothiazide / lisinopril: oral tablet


Oral route (Tablet)

Discontinue lisinopril/hydrochlorothiazide as soon as possible when pregnancy is detected, as drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Along with its needed effects, hydrochlorothiazide / lisinopril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / lisinopril:

Less common

  • Blurred vision
  • body aches or pain
  • chills
  • confusion
  • cough
  • diarrhea
  • difficulty breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • ear congestion
  • fever
  • headache
  • loss of voice
  • nasal congestion
  • nausea
  • runny nose
  • sneezing
  • sore throat
  • sweating
  • unusual tiredness or weakness
  • vomiting

Some side effects of hydrochlorothiazide / lisinopril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Belching
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • decreased interest in sexual intercourse
  • heartburn
  • inability to have or keep an erection
  • indigestion
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • muscle cramps
  • rash
  • stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to hydrochlorothiazide / lisinopril: oral tablet


The most common adverse reactions were dizziness, headache, cough, fatigue, and orthostatic effects.

Nervous system

Common (1% to 10%): Dizziness, headache, paresthesia

Uncommon (0.1% to 1%): Syncope

Frequency not reported: Vertigo, somnolence, tinnitus


Frequency not reported: Paresthesia, lightheadedness, vertigo


Common (1% to 10%): Dizziness, headache, syncope

Uncommon (0.1% to 1%): Paresthesia, vertigo, taste disturbance

Rare (less than 0.1%): Olfactory disturbance

Frequency not reported: Transient ischemic attacks, ataxia, memory impairment, tremor, stroke, peripheral neuropathy, hypersomnia


Common (1% to 10%): Cough, upper respiratory tract infection

Frequency not reported: Common cold, nasal congestion, bronchitis, pharyngeal pain, dyspnea, pulmonary congestion, chronic sinusitis, allergic rhinitis, pharyngeal discomfort


Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema


Common (1% to 10%): Cough

Uncommon (0.1% to 1%): Rhinitis

Very rare (less than 0.01%): Bronchospasm, sinusitis, allergic alveolitis/eosinophilic pneumonitis

Frequency not reported: Pulmonary embolism, pulmonary infarction, paroxysmal nocturnal dyspnea, malignant lung neoplasms, hemoptysis, pulmonary edema, pulmonary infiltrates, asthma, pleural effusion, pneumonia, wheezing, orthopnea, painful respiration, epistaxis, laryngitis, pharyngitis, rhinorrhea


Common (1% to 10%): Fatigue, asthenia

Frequency not reported: Chest pain, chest discomfort, fever, trauma, otalgia


Frequency not reported: Fever, weakness, cramping


Uncommon (0.1% to 1%): Asthenia, fatigue

Frequency not reported: Malaise, edema, facial edema, pain, chills, peripheral edema, chest sound abnormal, breast pain


Common (1% to 10%): Orthostatic effects, hypotension

Frequency not reported: Palpitation, flushing


Frequency not reported: Postural hypotension, necrotizing angiitis, vasculitis


Common (1% to 10%): Orthostatic effects

Uncommon (0.1% to 1%): Myocardial infarction or cerebrovascular accident, palpitation, tachycardia, Raynaud's syndrome

Frequency not reported: Flushing, cardiac arrest, worsening heart failure, arrhythmias, angina pectoris, decreased blood pressure, vasculitis


Common (1% to 10%): Diarrhea, nausea, vomiting, dyspepsia

Frequency not reported: Abdominal pain, gastrointestinal cramps, dry mouth, constipation, heartburn, intestinal angioedema


Frequency not reported: Sialadenitis, gastric irritation, diarrhea, constipation, pancreatitis


Common (1% to 10%): Diarrhea, vomiting

Uncommon (0.1% to 1%): Nausea, abdominal pain, indigestion

Rare (0.01% to 0.1%): Dry mouth

Very rare (less than 0.01%): Pancreatitis, intestinal angioedema

Frequency not reported: Gastritis, flatulence, salivation increased


Common (1% to 10%): Muscle cramps

Frequency not reported: Back pain, shoulder pain, knee pain, back strain, myalgia, foot pain


Frequency not reported: Systemic lupus erythematosus, muscle spasm, muscle weakness


Frequency not reported: Pelvic pain, flank pain, arthritis, arthralgia, neck pain, hip pain, joint pain, leg pain, arm pain, lumbago


Common (1% to 10%): Impotence

Frequency not reported: Urinary tract infection


Frequency not reported: Glycosuria


Uncommon (0.1% to 1%): Impotence

Frequency not reported: Dysuria


Frequency not reported: Pruritus, skin inflammation, diaphoresis, cutaneous pseudolymphoma, angioedema


Frequency not reported: Cutaneous vasculitis, photosensitivity reactions, rash, cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus, urticaria, toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, alopecia, purpura


Uncommon (0.1% to 1%): Rash, pruritus

Rare (0.01% to 0.1%): Angioedema, urticaria, alopecia, psoriasis

Very rare (less than 0.01%): Diaphoresis, pemphigus, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, cutaneous pseudolymphoma

Frequency not reported: Photosensitivity, skin lesions, skin infections


Frequency not reported: Xanthopsia, transient blurred vision, acute myopia, acute angle-closure glaucoma


Frequency not reported: Xanthopsia


Frequency not reported: Visual loss, diplopia, photophobia


Frequency not reported: Hemoglobin decreased, hematocrit decreased, anemia


Frequency not reported: Leukopenia, neutropenia/agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, bone marrow depression


Rare (0.01% to 0.1%): Hemoglobin decreased, hematocrit decreased

Very rare (less than 0.01%): Bone marrow depression, anemia, thrombocytopenia, leukopenia, neutropenia, agranulocytosis, hemolytic anemia, lymphadenopathy


Frequency not reported: BUN increased, serum creatinine increased


Frequency not reported: Renal dysfunction, interstitial nephritis, renal failure


Common (1% to 10%): Renal dysfunction

Uncommon (0.1% to 1%): Blood urea increased, serum creatinine increased

Rare (0.01% to 0.1%): Uremia, acute renal failure

Very rare (less than 0.01%): Oliguria/anuria

Frequency not reported: Progressive azotemia, pyelonephritis


Frequency not reported: Libido decreased, depression


Frequency not reported: Restlessness, depression, sleep disturbance


Uncommon (0.1% to 1%): Sleep disturbance, mood alteration, depressive symptoms

Rare (less than 0.1%): Mental confusion

Frequency not reported: Hallucination, insomnia, nervousness, irritability


Frequency not reported: Liver enzymes elevated, bilirubin elevated


Frequency not reported: Intrahepatic cholestatic jaundice


Uncommon (0.1% to 1%): Liver enzymes elevated, bilirubin elevated

Very rare (less than 0.01%): Hepatitis, jaundice, hepatic failure


Frequency not reported: Viral infection, influenza


Frequency not reported: Anaphylactic reactions


Very rare (less than 0.01%): Autoimmune disease

Frequency not reported: Anaphylactoid reactions, herpes zoster



Frequency not reported: Anorexia, hyperglycemia, hyperuricemia, hyponatremia, hypokalemia, hypochloremic alkalosis, hypomagnesemia, cholesterol increased, triglycerides increased, gout, appetite lost


Uncommon (0.1% to 1%): Hyperkalemia

Rare (0.01% to 0.1%): Hyponatremia

Very rare (less than 0.01%): Hypoglycemia

Frequency not reported: Anorexia, gout, weight loss, dehydration, fluid overload, weight gain



Rare (less than 0.1%): Syndrome of inappropriate antidiuretic hormone secretion, gynecomastia

Frequency not reported: Diabetes mellitus

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Zestoretic (www.drugs.com/zestoretic.html).