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Zantac

Generic Name: ranitidine (ra NI ti deen)
Brand Names: Zantac
Zantac is used to treat and prevent ulcers in the stomach and intestines. Includes Zantac side effects, interactions, indications, recalls, cancer risk warnings, FDA alerts, and news updates.
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Drug Information:
Zantac (ranitidine) belongs to a group of drugs called histamine-2 blockers. Ranitidine works by reducing the amount of acid your stomach produces. Zantac is used to treat and prevent ulcers in the stomach and intestines. It also treats conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome. Zantac is also used to treat gastroesophageal reflux disease (GERD) and other conditions in which acid backs up from the stomach into the esophagus, causing heartburn. Using Zantac may increase your risk of developing pneumonia. Symptoms of pneumonia include chest pain, fever, feeling short of breath, and coughing up green or yellow mucus. Talk with your doctor about your specific risk of developing pneumonia. Learn more

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Zantac Side Effects

Note: This document contains side effect information about ranitidine. Some of the dosage forms listed on this page may not apply to the brand name Zantac.

For the Consumer

Applies to ranitidine: oral solution, oral tablets and tablets for, oral tablets effervescent for solution, parenteral injection, parenteral injection for iv infusion only

Side effects include:

Oral or parenteral therapy: Headache, sometimes severe.

IM therapy: Transient pain at injection site.

IV therapy: Transient local burning or itching.

For Healthcare Professionals

Applies to ranitidine: compounding powder, injectable solution, intravenous solution, oral capsule, oral granule effervescent, oral syrup, oral tablet, oral tablet effervescent

General

The most commonly reported side effect for IM administration was injection site pain, and the most commonly reported side effects with IV administration were localized pain and burning.

Gastrointestinal

Uncommon (0.1% to 1%): Abdominal discomfort/pain, constipation, nausea, vomiting

Very rare (less than 0.01%): Acute pancreatitis, diarrhea

Abdominal pain, constipation, and nausea tended to improve with continued treatment.

Cardiovascular

Rare (0.01% to 0.1%): Hypotension, chest pain, arrhythmia, bradycardia, atrioventricular block, tachycardia, premature ventricular beats

Very rare (less than 0.01%): Asystole, vasculitis

Bradycardia, atrioventricular block, tachycardia, and asystole have occurred in H2 receptor antagonists.

Psychiatric

Rare (0.01% to 0.1%): Insomnia, reversible mental confusion, agitation, depression, hallucinations

Frequency not reported: Loss of libido

Nervous system

Headache may be related to administration of treatment.

Rare (0.01% to 0.1%): Dizziness, somnolence, vertigo, reversible involuntary movement disorders

Very rare (less than 0.01%): Headache/severe headache

Dermatologic

Rare (0.01% to 0.1%): Urticaria, angioneurotic edema, skin rash

Very rare (less than 0.01%): Erythema multiforme, alopecia

Musculoskeletal

Very rare (less than 0.01%): Musculoskeletal symptoms, arthralgia, myalgia

Hepatic

Rare (0.01% to 0.1%): Transient and reversible changes in liver function tests, increased ALT levels

Very rare (less than 0.01%): Hepatocellular/hepatocanalicular/mixed hepatitis with/without jaundice

Hepatitis with/without jaundice were usually reversible.

ALT levels increased to at least 2 times the pretreatment levels in patients receiving high IV doses for at least 5 days.

Other

Rare (0.01% to 0.1%): Fever, malaise

Frequency not reported: Death

Hypersensitivity

Rare (0.01% to 0.1%): Hypersensitivity reactions

Very rare (less than 0.01%): Anaphylactic shock/anaphylaxis

Anaphylactic shock occurred after administration of a single dose.

Renal

Rare (0.01% to 0.1%): Elevation in serum creatinine

Very rare (less than 0.01%): Acute interstitial nephritis

Elevation in serum creatinine was usually slight, and typically normalized with continued treatment.

Respiratory

Rare (0.01% to 0.1%): Bronchospasm

Frequency not reported: Dyspnea, pneumonia

Ocular

Rare (0.01% to 0.1%): Reversible blurred vision

Hematologic

Very rare (less than 0.01%): Blood count changes, leukopenia, thrombocytopenia, granulocytopenia, agranulocytosis, pancytopenia, marrow hypoplasia/aplasia

Frequency not reported: Aplastic anemia, immune hemolytic anemia/acquired immune hemolytic anemia, eosinophilia

Leukopenia, granulocytopenia, and thrombocytopenia were usually reversible.

Genitourinary

Very rare (less than 0.01%): Reversible impotence, breast symptoms/conditions, galactorrhea

Endocrine

Very rare (less than 0.01%): Gynecomastia

Metabolic

Postmarketing reports: Acute porphyria

Local

Frequency not reported: Injection site pain, transient localized burning or itching

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Zantac (www.drugs.com/zantac.html).