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More frequently reported side effects include: amnesia and dizziness. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to zaleplon: oral capsule
Along with its needed effects, zaleplon may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking zaleplon:
Less common
Rare
Get emergency help immediately if any of the following symptoms of overdose occur while taking zaleplon:
Symptoms of overdose
Some side effects of zaleplon may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:
For Healthcare Professionals
Applies to zaleplon: oral capsule
GeneralThe most commonly reported side effects included headache, dizziness, nausea, asthenia, and somnolence.
Nervous systemVery common (10% or more): Headache (up to 42%)
Common (1% to 10%): Amnesia, difficulty concentrating, dizziness, hypertonia, hypesthesia, migraine, paresthesia, parosmia, somnolence, taste perversion, tremor, vertigo
Uncommon (0.1% to 1%): Abnormal gait, ataxia, hyperesthesia, hyperkinesia, hypotonia, incoordination, neuralgia, nystagmus
Rare (less than 0.1%): Central nervous system (CNS) stimulation, cerebral ischemia, decreased reflexes, dysarthria, dystonia, facial paralysis, hypokinesia, increased reflexes, myoclonus, neuropathy, slurred speech, stupor, taste loss, visual field defect
PsychiatricCommon (1% to 10%): Abnormal thinking, anxiety, confusion, depersonalization, depression, hallucinations, nervousness
Uncommon (0.1% to 1%): Agitation, apathy, decreased libido, emotional lability, euphoria, insomnia
Rare (less than 0.1%): Bruxism, delusions, hostility, psychomotor retardation, sleep talking, sleep walking
Postmarketing reports: Nightmares
GastrointestinalCommon (1% to 10%): Abdominal pain, colitis, constipation, dry mouth, dyspepsia, nausea
Uncommon (0.1% to 1%): Circumoral paresthesia, eructation, esophagitis, flatulence, gastritis, gastroenteritis, gingivitis, glossitis, mouth ulceration, rectal hemorrhage, stomatitis
Rare (less than 0.1%): Aphthous stomatitis, cardiospasm, cheilitis, duodenal ulcer, dysphagia, enteritis, gum hemorrhage, increased salivation, intestinal obstruction, peptic ulcer, tongue discoloration, tongue edema, ulcerative stomatitis
OtherCommon (1% to 10%): Asthenia, ear pain, fever, hyperacusis, malaise
Uncommon (0.1% to 1%): Chills, face edema, hangover effect, substernal chest pain, tinnitus
Rare (less than 0.1%): Deafness, labyrinthitis
MusculoskeletalCommon (1% to 10%): Arthralgia, arthritis, back pain, myalgia
Uncommon (0.1% to 1%): Arthrosis, bursitis, joint disorder, joint pain, joint stiffness, joint swelling, neck rigidity, myasthenia, tenosynovitis
Rare (less than 0.1%): Myositis, osteoporosis, trismus
DermatologicCommon (1% to 10%): Photosensitivity reaction, pruritus, rash
Uncommon (0.1% to 1%): Acne, alopecia, contact dermatitis, dry skin, ecchymosis, eczema, maculopapular rash, skin hypertrophy, sweating, urticaria, vesiculobullous rash
Rare (less than 0.1%): Melanosis, psoriasis, purpura, pustular rash, skin discoloration
OcularCommon (1% to 10%): Abnormal vision, conjunctivitis, eye pain
Uncommon (0.1% to 1%): Diplopia, dry eyes, photophobia, watery eyes
Rare (less than 0.1%): Abnormality of accommodation, blepharitis, cataract specified, corneal erosion, eye hemorrhage, glaucoma, ptosis, retinal detachment
CardiovascularCommon (1% to 10%): Chest pain, peripheral edema
Uncommon (0.1% to 1%): Angina pectoris, bundle branch block, edema, generalized edema, hypertension, hypotension, palpitation, tachycardia, vasodilation, ventricular extrasystoles
Rare (less than 0.1%): Bigeminy, cyanosis, pericardial effusion, postural hypotension, sinus bradycardia, thrombophlebitis, ventricular tachycardia
RespiratoryCommon (1% to 10%): Bronchitis, epistaxis
Uncommon (0.1% to 1%): Asthma, dyspnea, laryngitis, pneumonia, snoring, voice alteration
Rare (less than 0.1%): Apnea, hiccup, hyperventilation, increased sputum, pleural effusion, pulmonary embolus
GenitourinaryCommon (1% to 10%): Dysmenorrhea
Uncommon (0.1% to 1%): Bladder pain, breast pain, cystitis, decreased urine stream, dysuria, hematuria, impotence, menorrhagia, metrorrhagia, urinary frequency, urinary incontinence, urinary urgency, vaginitis
Rare (less than 0.1%): Albuminuria, delayed menstrual period, leukorrhea, menopause, urethritis, urinary retention, vaginal hemorrhage
MetabolicCommon (1% to 10%): Anorexia
Uncommon (0.1% to 1%): Gout, hypercholesteremia, increased appetite, thirst, weight gain
Rare (less than 0.1%): Diabetes mellitus, hyperglycemia, hyperuricemia, hypoglycemia, hypoglycemic reaction, ketosis, lactose intolerance, weight loss
HematologicUncommon (0.1% to 1%): Anemia, lymphadenopathy
Rare (less than 0.1%): Eosinophilia, leukocytosis, lymphocytosis
RenalUncommon (0.1% to 1%): Kidney calculus, kidney pain
HepaticRare (less than 0.1%): Abnormal liver function tests, bilirubinemia, biliary pain, cholelithiasis, increased ALT, increased AST
EndocrineRare (less than 0.1%): Goiter, hypothyroidism
HypersensitivityPostmarketing reports: Anaphylactic/anaphylactoid reactions, severe anaphylactic/anaphylactoid reactions
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Zaleplon (www.drugs.com/mtm/zaleplon.html).
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