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Zafirlukast

Generic Name: zafirlukast (za FIR loo kast)
Brand Name: Accolate
Physician reviewed zafirlukast patient information - includes zafirlukast description, dosage and directions.
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Zafirlukast Coupons & Prices

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Drug Information:
Zafirlukast is a leukotriene (loo-koe-TRY-een) inhibitor. Leukotrienes are chemicals your body releases when you breathe in an allergen (such as pollen). These chemicals cause swelling in your lungs and tightening of the muscles around your airways, which can result in asthma symptoms. Zafirlukast is used for chronic treatment of asthma, and to prevent asthma attacks in adults and children as young as 5 years old. Do not give zafirlukast to a child younger than 5 years without a doctor's advice. Learn more

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Zafirlukast Side Effects

For the Consumer

Applies to zafirlukast: oral tablet

Along with its needed effects, zafirlukast may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking zafirlukast:

Less common

  • Cough or hoarseness
  • fever or chills
  • lower back or side pain
  • pain
  • painful or difficult urination

Rare

  • Abdominal or stomach pain
  • clay-colored stools
  • dark urine
  • diarrhea
  • dizziness
  • headache
  • itching
  • loss of appetite
  • nausea
  • rash
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin

Incidence not known

  • Attack, assault, or force
  • attempts at killing oneself
  • discouragement
  • dry mouth
  • fear or nervousness
  • feeling sad or empty
  • fever with or without chills
  • general feeling of tiredness or weakness
  • hyperventilation
  • irregular heartbeats
  • irritability
  • lack of appetite
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of interest or pleasure
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • shakiness in the legs, arms, hands, or feet
  • shortness of breath
  • sleeplessness
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • tiredness
  • trembling or shaking of the hands or feet
  • trouble with concentrating
  • trouble with sleeping
  • unable to sleep
  • unusual bleeding or bruising

Some side effects of zafirlukast may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Acid or sour stomach
  • back pain
  • belching
  • difficulty with moving
  • heartburn
  • indigestion
  • joint pain
  • lack or loss of strength
  • muscle aching or cramping
  • muscle pains or stiffness
  • stomach discomfort or upset
  • swollen joints
  • vomiting

Incidence not known

  • Hives or welts
  • redness of the skin

For Healthcare Professionals

Applies to zafirlukast: oral tablet

General

The most commons adverse effects may be associated with headache or gastrointestinal disturbances. These symptoms are usually mild.

Nervous system

Very common (10% or more): Headache (up to 12.9%)

Common (1% to 10%): Dizziness (1.6%)

Frequency not reported: Neuropathy, neuropsychiatric events

Gastrointestinal

Common (1% to 10%): Nausea (up to 3.1%), diarrhea (up to 2.8%), abdominal pain (up to 2.8%), vomiting (up to 1.5%), dyspepsia (1.3%)

Hepatic

In most of the postmarketing reports, the patient's symptoms abated and the liver enzymes returned to normal or near normal after stopping this drug.

Common (1% to 10%): SGPT elevation (1.5%), AST (1.4%)

Rare (less than 0.1%): Hyperbilirubinemia without other elevated liver function tests; fulminant hepatitis or progressed to hepatic failure, liver transplantation and death

Postmarketing reports: Symptomatic hepatitis (with or without hyperbilirubinemia) without other attributable cause; hepatic dysfunction

Musculoskeletal

Common (1% to 10%): Myalgia (1.6%), back pain (1.5%)

Frequency not reported: Arthralgia

Other

Common (1% to 10%): Generalized pain (1.9%), asthenia (up to 1.8%), accidental injury (1.6%), fever (1.4%)

Rare (less than 0.1%): Increased theophylline levels with or without clinical signs or symptoms of theophylline toxicity when this drug was added to an existing theophylline regime.

Frequency not reported: Edema, malaise

Respiratory

Common (1% to 10%): Respiratory tract infection (3.5%)

Infections were usually mild or moderate, predominantly affecting the respiratory tract and not necessitating withdrawal from the therapy.

In clinical trials, an increased proportion of patients over the age of 55 years reported these infections. Infections occurred equally in both sexes and were associated with coadministration of inhaled corticosteroids.

Cardiovascular

Rare (less than 0.1%): Bleeding disorders including menorrhagia, thrombocytopenia

Dermatologic

Rare (less than 0.1%): Alopecia

Frequency not reported: Bruising, pruritus

Hematologic

Rare (0.01% to 0.1%): Granulomatosis

Very rare (less than 0.01%): Agranulocytosis

Immunologic

Systemic eosinophilia may also involve various body systems including vasculitic rash, worsening pulmonary symptoms, cardiac complications or neuropathy.

Rare (less than 0.1%): Systemic eosinophilia, eosinophilic pneumonia, or clinical features of vasculitis consistent with Churg-Strauss syndrome

Hypersensitivity

Frequency not reported: Urticaria, angioedema, rashes (with or without blistering)

Psychiatric

Frequency not reported: Insomnia, depression

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Zafirlukast (www.drugs.com/mtm/zafirlukast.html).