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Xyzal Prescription
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Generic Name: levocetirizine (LEE voe se TIR a zeen)
Brand Names: Xyzal
Xyzal (levocetirizine) is used to treat cold or allergy symptoms such as sneezing and runny nose and to treat hives. Includes Xyzal side effects, interactions and indications. Average Savings for levocetirizine dihydrochl (generic): 68.1%
Generic Name: levocetirizine (LEE voe se TIR a zeen)
Brand Names: Xyzal
Xyzal (levocetirizine) is used to treat cold or allergy symptoms such as sneezing and runny nose and to treat hives. Includes Xyzal side effects, interactions and indications. Average Savings for levocetirizine dihydrochl (generic): 68.1%
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Xyzal Drug Information:

Xyzal (levocetirizine) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms such as a runny nose or hives. Xyzal is used to treat symptoms of year-round (perennial) allergies in children who are at least 6 months old. Xyzal is also used to treat itching and swelling caused by chronic urticaria (hives) in adults and children who are at least 6 months old. Before taking Xyzal, tell your doctor if you have liver disease, kidney disease, or gallbladder problems. Learn more

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Xyzal Side Effects

Note: This document contains side effect information about levocetirizine. Some of the dosage forms listed on this page may not apply to the brand name Xyzal.

In Summary

More frequent side effects include: drowsiness, fatigue, and nasopharyngitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to levocetirizine: oral solution, oral tablet

Along with its needed effects, levocetirizine (the active ingredient contained in Xyzal) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking levocetirizine:

Less common

  • Bloody nose
  • fever

Incidence not known

  • Anxiety
  • attack, assault, or force
  • blurred or loss of vision
  • cough
  • dark urine
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficult or labored breathing
  • difficulty in passing urine (dribbling)
  • difficulty with swallowing
  • disturbed color perception
  • dizziness
  • double vision
  • dry mouth
  • fast, irregular, pounding, or racing heartbeat or pulse
  • general tiredness and weakness
  • halos around lights
  • hives or welts
  • hyperventilation
  • irritability
  • itching skin
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • nausea and vomiting
  • nervousness
  • night blindness
  • overbright appearance of lights
  • painful urination
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • restlessness
  • seizures
  • shaking
  • skin rash
  • tightness in the chest
  • trouble with sleeping
  • tunnel vision
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Some side effects of levocetirizine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Headache
  • muscle aches
  • sleepiness or unusual drowsiness
  • sore throat
  • stuffy or runny nose

Less common

  • Body aches or pain
  • congestion
  • diarrhea
  • dryness or soreness of the throat
  • earache
  • hoarseness
  • redness or swelling in the ear
  • tender, swollen glands in the neck
  • voice changes

For Healthcare Professionals

Applies to levocetirizine: oral solution, oral tablet


The most frequently reported side effects were: somnolence, nasopharyngitis, fatigue, dry mouth, and pharyngitis (in 12 years and older); pyrexia, somnolence, cough, and epistaxis (in patients 6 to 12 years); pyrexia, diarrhea, vomiting, and otitis media (in patients 1 to 5 years); diarrhea and constipation (in patients 6 to 11 months).

Nervous system

Common (1% to 10%): Somnolence, dizziness, headache

Uncommon (0.1% to 1%): Paresthesia, syncope

Rare (0.01% to 0.1%): Convulsion, movement disorder

Very rare (less than 0.01%): Dysgeusia, tremor, dystonia, dyskinesia

Frequency not reported: Orofacial dyskinesia, myoclonus, extrapyramidal symptoms

Postmarketing reports: Febrile seizure


Very rare (less than 0.01%): Accommodation disorder, vision blurred, oculogyration

Postmarketing reports: Visual disturbance


Common (1% to 10%): Nasopharyngitis, pharyngitis, cough, epistaxis, rhinitis

Postmarketing reports: Dyspnea


Common (1% to 10%): Dry mouth, diarrhea, vomiting, constipation, abdominal pain

Postmarketing reports: Nausea


Common (1% to 10%): Fatigue, pyrexia, otitis media

Uncommon (0.1% to 1%): Weight increased, asthenia, malaise

Rare (less than 0.1%): Edema

Frequency not reported: Stillbirth

Postmarketing reports: Vertigo


Uncommon (0.1% to 1%): Agitation

Rare (0.01% to 0.1%): Aggression, confusion, depression, hallucination, insomnia

Very rare (less than 0.01%): Tic, enuresis

Postmarketing reports: Suicidal ideation, nightmare


Very rare (less than 0.01%): Dysuria

Postmarketing reports: Urinary retention


Rare (less than 0.1%): Tachycardia

Frequency not reported: Severe hypotension

Postmarketing reports: Palpitation


Uncommon (0.1% to 1%): Pruritus, rash

Rare (0.01% to 0.1%): Urticaria

Very rare (less than 0.01%): Angioedema, fixed drug eruption

Frequency not reported: Acute generalized exanthematous pustulosis


Rare (less than 0.1%): Hepatic function abnormal, transaminases increased, bilirubin increased

Frequency not reported: Cholestasis

Postmarketing reports: Hepatitis


Very rare (less than 0.01%): Thrombocytopenia


Rare (0.01% to 0.1%): Hypersensitivity

Very rare (less than 0.01%): Anaphylactic shock


Frequency not reported: Glomerulonephritis


Postmarketing reports: Appetite increased


Postmarketing reports: Myalgia, arthralgia

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Xyzal (www.drugs.com/xyzal.html).