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Xrylix

Generic Name: Diclofenac Topical Solution (dye KLOE fen ak)
Brand Name: Klofensaid II, Pennsaid, Vopac MDS, Xrylix
Easy-to-read patient leaflet for Xrylix. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
This is not a list of all drugs or health problems that interact with Xrylix (diclofeNac topical solution). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Xrylix (diclofeNac topical solution) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use Xrylix (diclofeNac topical solution) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

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Xrylix Side Effects

Note: This document contains side effect information about diclofenac topical. Some of the dosage forms listed on this page may not apply to the brand name Xrylix.

For the Consumer

Applies to diclofenac topical: topical application cream, topical application gel/jelly, topical application patch extended release, topical application solution, topical application spray

Warning

Topical route (Gel/Jelly; Solution)

NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use. Diclofenac sodium is contraindicated in the setting of coronary artery bypass graft surgery. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.

Topical application route (Patch, Extended Release)

NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use. Diclofenac epolamine is contraindicated in the setting of coronary artery bypass graft surgery. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.

Along with its needed effects, diclofenac topical (the active ingredient contained in Xrylix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking diclofenac topical:

More common

  • Application site reactions, including skin rash, pain, tingling, or burning sensation
  • flu-like syndrome (body ache, headache, fever, with or without chills)
  • itching skin

Less common or rare

  • Blood in the urine
  • cough
  • dry, itching, or burning eyes
  • eye pain
  • headaches, including migraines
  • increased sensitivity of the skin
  • nasal congestion
  • pain or tenderness around the eyes and cheekbones
  • redness of the skin
  • redness or swelling of the eyes
  • skin rash other than at the application site
  • sore throat
  • tightness in the chest
  • troubled breathing
  • ulcers or sores on the skin, other than at the application site

Some side effects of diclofenac topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Burning skin
  • dry skin
  • scaly skin
  • thickened skin
  • tingling skin

Less common

  • Acne
  • back pain
  • belching
  • bleeding skin
  • chest pain
  • diarrhea
  • heartburn
  • indigestion
  • joint pain
  • lack or loss of strength
  • loss or thinning of the hair
  • muscle pain
  • neck pain
  • runny nose
  • stomach upset or pain

For Healthcare Professionals

Applies to diclofenac topical: topical cream, topical film extended release, topical gel, topical kit, topical solution

General

The most frequently reported side effects were application site reactions.

Local

Very common (10% or more): Dryness (up to 32%)

Common (1% to 10%): Dermatitis, burning sensation, pruritus, exfoliation, erythema, pain, induration, rash, scabbing, contusion, inflammation, irritation, itching, tingling, blistering, localized paresthesia

Frequency not reported: Vesicles, papules, localized hair discoloration, vasodilation, purpuric rash, atrophy

Dermatologic

Common (1% to 10%): Contact dermatitis, eczema, dry skin, rash, scaly rash, skin hypertrophy, skin ulcer, vesiculobullous rash, exfoliation, urticaria, acne, alopecia, skin nodule

Uncommon (0.1% to 1%): Face edema, maculopapular rash, photosensitivity reaction, seborrhea

Rare (0.01% to 0.1%): Bullous dermatitis

Very rare (less than 0.01%): Pustular rash

Frequency not reported: Skin hypertrophy

Cardiovascular

Common (1% to 10%): Hypertension

Uncommon (0.1% to 1%): Hemorrhage

Postmarketing reports: Palpitation, cardiovascular disorder, blood pressure increased

Gastrointestinal

Common (1% to 10%): Abdominal pain, diarrhea, dyspepsia, halitosis, nausea, flatulence, constipation

Very rare (less than 0.01%): Gastrointestinal hemorrhage

Frequency not reported: Upper abdominal pain

Postmarketing reports: Dry mouth, gastroenteritis, mouth ulceration, rectal hemorrhage, ulcerative stomatitis, lip swelling, swollen tongue

Nervous system

Common (1% to 10%): Headache, migraine, hypokinesia, dysgeusia, somnolence, hypertonia, hyperesthesia, paresthesia

Postmarketing reports: Dizziness, drowsiness, lethargy, taste perversion

Renal

Common (1% to 10%): Creatinine increased

Very rare (less than 0.01%): Renal failure

Hepatic

Common (1% to 10%): SGOT increased, SGPT increased

Metabolic

Common (1% to 10%): Hypercholesterolemia, hyperglycemia

Postmarketing reports: Appetite decreased

Musculoskeletal

Common (1% to 10%): Back pain, neck pain, arthralgia, arthrosis, myalgia

Postmarketing reports: Leg cramps

Ocular

Common (1% to 10%): Eye pain, conjunctivitis

Uncommon (0.1% to 1%): Lacrimation disorder

Postmarketing reports: Abnormal vision, blurred vision, cataract, eye disorder

Respiratory

Common (1% to 10%): Asthma, dyspnea, pharyngitis, pneumonia, rhinitis, sinusitis, sinus congestion

Postmarketing reports: Laryngismus, laryngitis

Other

Common (1% to 10%): Accidental injury, asthenia, chest pain, flu-like syndrome, infection, pain, creatine phosphokinase increased, edema

Postmarketing reports: Lack of drug effect, body odor, ear pain

Oncologic

Common (1% to 10%): Skin carcinoma

Genitourinary

Common (1% to 10%): Hematuria, urinary tract infection

Immunologic

Common (1% to 10%): Allergic reaction

Psychiatric

Postmarketing reports: Depression

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Xrylix (www.drugs.com/cdi/xrylix.html).