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Xopenex (levalbuterol) is a short-acting bronchodilator that relaxes muscles in the airways and increases air flow to the lungs.
Xopenex inhalation is used to treat or prevent bronchospasm in people with reversible obstructive airway disease.
Xopenex solution is for use in adults and children 6 years of age and older. Xopenex HFA aerosol is for use in adults and children 4 years of age and older.
You should not use Xopenex if you are allergic to levalbuterol or albuterol (Accuneb, ProAir, Proventil, Ventolin).
Before using Xopenex, tell your doctor if you have heart disease, high blood pressure, congestive heart failure, a heart rhythm disorder, a seizure disorder, diabetes, or overactive thyroid.
Tell your doctor about all other medicines you use, especially heart or blood pressure medication, diuretics (water pills), antidepressants, or other inhaled bronchodilators.
Talk with your doctor if any of your asthma medications do not seem to work as well in treating or preventing attacks. If it seems like you need to use more of any of your medications in a 24-hour period, talk with your doctor. An increased need for medication could be an early sign of a serious asthma attack.
It is very important that you use nebulized Xopenex properly, so that the medicine gets into the lungs. Talk to your doctor about proper nebulizer use.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of levalbuterol can be fatal.
You should not use Xopenex if you are allergic to levalbuterol or albuterol (Accuneb, ProAir, Proventil, Ventolin).
To make sure Xopenex is safe for you, tell your doctor if you have:
heart disease, high blood pressure, or congestive heart failure;
a seizure disorder;
diabetes; or
a thyroid disorder.
It is not known whether Xopenex will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether levalbuterol passes into breast milk or if it could affect a nursing baby. Tell your doctor if you are breast-feeding.
A Xopenex inhaler should not be given to a child younger than 4 years old. Xopenex solution in a nebulizer should not be given to a child younger than 6 years old.
Use Xopenex exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Any child using Xopenex should be supervised by an adult while using this medicine.
Prime the Xopenex inhaler device before your first use. Pump 4 test sprays into the air, away from your face. Shake the inhaler for at least 5 seconds before each spray. Prime again whenever the inhaler has not been used in longer than 3 days.
To use the Xopenex inhaler:
Shake the canister well just before each spray.
Uncap the mouthpiece of the inhaler. Breathe out fully. Put the mouthpiece into your mouth and close your lips. Breathe in slowly while pushing down on the canister. Hold your breath for 10 seconds, then breathe out slowly.
If you use more than one inhalation at a time, wait at least 1 minute before using the second inhalation and shake the inhaler again.
Keep your inhaler clean and dry, and store it with the cap on the mouthpiece. Clean your inhaler once a week by removing the canister and placing the mouthpiece under warm running water for at least 30 seconds. Shake out the excess water and allow the parts to air dry completely before putting the inhaler back together.
Store the Xopenex inhaler with the mouthpiece down. Keep the inhaler at room temperature away from heat, sunlight, or freezing temperatures.
If your inhaler has a dose number indicator on it, throw away the inhaler when the number displays "0" to show that all sprays have been used.
Keep the inhaler canister away from open flame or high heat, such as in a car on a hot day. The canister may explode if it gets too hot. Do not puncture or burn an empty inhaler canister.
Xopenex concentrate solution is given with a nebulizer. The concentrate must be mixed with a liquid (diluent) before using it. Ask your pharmacist about which diluent to use and where you can buy it. Be sure you understand how to properly mix the medicine and place it into the nebulizer.
To use the Xopenex solution with a nebulizer:
Open the foil pouch and empty the medicine into the chamber of the nebulizer. Add the correct amount of diluent as directed by your doctor.
Attach the mouthpiece or face mask, then attach the drug chamber to the compressor.
Sit upright in a comfortable position. Place the mouthpiece into your mouth or put on the face mask, covering your nose and mouth. Turn on the compressor.
Breathe in slowly and evenly until no more mist is formed by the nebulizer and the drug chamber is empty.
Clean the nebulizer after each use. Follow the cleaning directions that came with your nebulizer.
Do not use the nebulizer solution if it does not appear clear and colorless.
Store the Xopenex concentrate vials in the protective foil pouch at room temperature, away from moisture, heat, and light. Keep each vial in the foil pouch until you are ready to prepare a dose in the nebulizer.
Each single-use plastic vial of Xopenex concentrate is for one use only. Throw away after one use, even if there is still some medicine left in it after inhaling your dose.
Asthma is often treated with a combination of drugs. Use all medications as directed by your doctor. Do not change your doses or medication schedule without your doctor's advice.
Using too much Xopenex or using it too often can cause life-threatening side effects. Seek medical attention if you think your asthma medications are not working as well. An increased need for medication could be an early sign of a serious asthma attack.
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
Use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of levalbuterol can be fatal.
Avoid situations that may make your condition worse such as exercising in cold, dry air; smoking; breathing in dust; and exposure to allergens such as pet fur.
Get emergency medical help if you have signs of an allergic reaction to Xopenex: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
wheezing, choking, or other breathing problems after using this medicine;
pounding heartbeats or fluttering in your chest;
worsening asthma symptoms; or
low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, extreme thirst, increased urination, numbness or tingling, muscle weakness or limp feeling.
Common Xopenex side effects may include:
dizziness, nervousness, tremors;
runny nose, sore throat;
chest pain or tightness, irregular heartbeats;
pain; or
vomiting.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor if you have used an MAO inhibitor in the past 14 days. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Tell your doctor about all your current medicines and any you start or stop using, especially:
any other inhaled medicines to treat asthma or COPD (chronic obstructive pulmonary disease);
an antidepressant;
a diuretic or "water pill"; or
medicine to treat a heart condition.
This list is not complete. Other drugs may interact with levalbuterol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Xopenex only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Xopenex (www.drugs.com/xopenex.html).
Note: This document contains side effect information about levalbuterol. Some of the dosage forms listed on this page may not apply to the brand name Xopenex.
Common side effects of Xopenex include: rhinitis. Other side effects include: nervousness and tremor. See below for a comprehensive list of adverse effects.
Applies to levalbuterol: inhalation aerosol powder, inhalation solution
Along with its needed effects, levalbuterol (the active ingredient contained in Xopenex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking levalbuterol:
More common
Less common or rare
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking levalbuterol:
Symptoms of overdose
Some side effects of levalbuterol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common or rare
Applies to levalbuterol: inhalation aerosol, inhalation solution
This drug has been associated with paradoxical bronchospasm, cardiovascular effects, immediate hypersensitivity reactions, and hypokalemia.
ECG abnormal, ECG change, hypotension, and syncope occurred in less than 2%.
Common (1% to 10%): Hypertension, tachycardia
Frequency not reported: ECG abnormal, ECG change, hypotension, syncope
Postmarketing reports: Arrhythmias (including atrial fibrillation, supraventricular tachycardia, extrasystoles)
Myalgia occurred in less than 2%.
Common (1% to 10%): Leg cramps
Frequency not reported: Myalgia
Metabolic acidosis occurred in less than 2%.
Frequency not reported: Changes in plasma glucose and serum potassium; metabolic acidosis
Central nervous system stimulation and hyperesthesia of the hand occurred in less than 2%.
Common (1% to 10%): Dizziness, migraine, tremor, nervousness
Frequency not reported: Central nervous system stimulation, hyperesthesia of the hand
Common (1% to 10%): Pain, flu syndrome, accidental injury, asthenia, fever
Frequency not reported: Ear pain, herpes simplex, chills, cyst
Ear pain, herpes simplex, chills, and cyst occurred in less than 2%.
Diarrhea, dry mouth, dry throat, nausea, gastroenteritis, vomiting, and constipation occurred in less than 2%.
Common (1% to 10%): Dyspepsia
Frequency not reported: Diarrhea, dry mouth, dry throat, nausea, gastroenteritis, vomiting, constipation
Postmarketing reports: Gastroesophageal reflux disease (GERD), nausea
Common (1% to 10%): Asthma, pharyngitis, rhinitis, bronchitis, sinusitis, turbinate edema, cough increased, viral infection
Frequency not reported: Epistaxis, lung disorder, asthma exacerbation, wheezing
Postmarketing reports: Chest pain, dysphonia, dyspnea
Viral infection, epistaxis, lung disorder, asthma exacerbation, and wheezing occurred in less than 2%.
Frequency not reported: Acne, sweating
Postmarketing reports: Rash, urticaria
Acne and sweating occurred less than 2%.
Common (1% to 10%): Allergic reactions
Postmarketing reports: Angioedema, anaphylaxis
Frequency not reported: Hematuria, dysmenorrhea, vaginal moniliasis
Hematuria, dysmenorrhea, vaginal moniliasis occurred in less than 2%.
Frequency not reported: Lymphadenopathy
Lymphadenopathy occurred in less than 2%.
Eye itch occurred in less than 2%.
Frequency not reported: Eye itch
Insomnia occurred in less than 2%.
Common (1% to 10%): Anxiety
Frequency not reported: Insomnia
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Xopenex (www.drugs.com/xopenex.html).
July 13, 2020
July 13, 2020
July 13, 2020
July 13, 2020
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June 26, 2020
