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Xiidra Prescription
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Generic Name: lifitegrast ophthalmic (LIF e TEG rast off THAL mik)
Brand Names: Xiidra
Xiidra (lifitegrast) is used to treat dry eye disease. Includes Xiidra side effects, interactions and indications.
Generic Name: lifitegrast ophthalmic (LIF e TEG rast off THAL mik)
Brand Names: Xiidra
Xiidra (lifitegrast) is used to treat dry eye disease. Includes Xiidra side effects, interactions and indications.
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12 tablets of Xiidra 40 mg
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Don’t see your pharmacy listed? Most pharmacies accept our discounts, so have your pharmacist enter this coupon to see if you will save money:

Xiidra Drug Information:

Xiidra (lifitegrast) works by blocking a certain protein on the surface of cells in your body. This protein can cause your eyes to not produce enough tears, or to produce tears that are not the correct consistency to keep your eyes healthy. Xiidra eye drops are used to treat symptoms of dry eye disease. Xiidra may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare prOviders about all your medical conditions, allergies, and all medicines you use. Learn more

Xiidra Medicare Coverage

Xiidra Medicare Overview

Does Medicare cover Xiidra?


62% of Medicare Part D and Medicare Advantage plans cover this drug.
How much is my Xiidra co-pay with Medicare?

It depends. Which coverage stage are you in? Click on a tab below…


$4 – $69

In the Deductible co-pay stage, you are responsible for the full cost of your prescriptions. Your Medicare deductible cannot exceed $360 in 2016.

Ways to Save on Xiidra

Here are some ways that may lower the cost of your xiidra prescription.

  • Instead of Medicare, Use a USA Rx Coupon

    If your Medicare co-pay is higher, you can save money by using a USARx coupon instead.

Xiidra Side Effects

Note: This document contains side effect information about lifitegrast ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Xiidra.

For the Consumer

Applies to lifitegrast ophthalmic: ophthalmic solution

Along with its needed effects, lifitegrast ophthalmic (the active ingredient contained in Xiidra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lifitegrast ophthalmic:

More common

  • Changes in vision
  • eye irritation or discomfort

Less common

  • Blurred vision
  • redness of the white part of the eyes or inside of the eyelids

Some side effects of lifitegrast ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Change in taste
  • loss of taste

Less common

  • Cough
  • discomfort or itching of the eyes
  • drainage from the eyes
  • fever
  • headache
  • pain or tenderness around the eyes and cheekbones
  • stuffy or runny nose
  • tightness of the chest
  • troubled breathing
  • watering of the eyes

For Healthcare Professionals

Applies to lifitegrast ophthalmic: ophthalmic solution


The most commonly reported side effects included instillation site irritation, dysgeusia, and reduced visual acuity.


Common (1% to 10%): Increased lacrimation, reduced visual acuity, blurred vision, conjunctival hyperemia, eye irritation, eye discharge/pruritus/discomfort

Nervous system

Common (1% to 10%): Dysgeusia, headache


Common (1% to 10%): Instillation site irritation


Common (1% to 10%): Sinusitis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Xiidra (www.drugs.com/xiidra.html).

What pharmacies accept this discount program?

Rite Aid, Wal-Mart, Walgreens, CVS, Duene Reade, Target, K-mart, and all national and regional chains accept the card.

What if you didn’t find your pharmacy names above?

Not to worry, you can search our pharmacy network on our homepage.

What if the pharmacist refuses to take this prescription discount card?

If they are in the participating network, they legally have to accept and process the card. We work with drug manufacturers to lower your out of pocket expenses. If they need help in processing the card, have them call the support phone number or email us directly.

What if the dosage, quantity, or drug name of the Xiidra coupon I downloaded is different than what I’m trying to fill right now?

Any Xiidra coupon can be applied to any prescription medication for dry eyes at a participating pharmacy and receive the discount price, not just the brand name drug. Prescription Prices are subject to change.

Does this free Xiidra coupon work for brand name drug and the generic version?

Yes, both generic and brand prescription medication for dry eyes are covered by the coupon. Remember, any coupon can be applied to any prescription medication at a participating pharmacy and receive a discount with maximum savings intended to reduce Xiidra cost.

Does this work with my government insurance coverage, like Medicaid?

No, you must decide at the pharmacy either to use your USA Rx Xiidra coupon or your insurance. 

Xiidra Prescription Savings Explained

FAQ Disclaimer: USA Rx LLC has a full endorsement of our prescription savings card discount program. This product does not replace your insurance plan. You may check the price of both your insurance plan (copay) and our patient assistance program. That is an easy step to get the lowest out of pocket cost on your prescriptions for dry eyes. Our affiliates use the “powered by USA Rx” symbol in marketing materials. If you have a medical condition and need assistance with figuring out what your best option is for a discount program of prescription savings, please give us a call or drop us an email. Check to see if there are any manufacturer coupons available to you for your prescription. There are no membership fees associated with USA Rx LLC. If you need medical help, please seek proper medical care as soon as possible. If you have dry eyes, chat with your doctor or pharmacist about common side effects of xiidra prescription eye drops. You can also speak with your doctor about a possible xiidra price guide. All cardholders adhere to our privacy policy and we use recent information to create our pricing estimates, which are subject to change. Prescription Prices are subject to change.