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Generic Name: acyclovir and hydrocortisone topical (a SYE kloe vir and HYE droe KOR ti sone TOP ik al)
Brand Names: Xerese
Xerese cream is used to shorten the healing time of cold sores and to lower the chance of a cold sore becoming worse. Includes Xerese side effects, interactions and indications.
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Drug Information:
Xerese cream contains a combination of Acyclovir and Hydrocortisone. Acyclovir is an antiviral drug. It slows the growth and spread of the herpes virus so that the body can fight off the infection. Hydrocortisone is a topical (for the skin) corticosteroid. It reduces the actions of chemicals in the body that cause inflammation. Xerese cream is a prescription medicine used to treat cold sores in people who are at least 12 years old. Xerese will not cure or prevent cold sores caused by herpes, but it can lessen the symptoms of the infection. Learn more

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Xerese Side Effects

Note: This document contains side effect information about acyclovir / hydrocortisone topical. Some of the dosage forms listed on this page may not apply to the brand name Xerese.

For the Consumer

Applies to acyclovir/hydrocortisone topical: topical application cream

Along with its needed effects, acyclovir/hydrocortisone topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking acyclovir/hydrocortisone topical:


  • Burning, itching, redness, rash, swelling, soreness, or tingling at the application site
  • change in skin color at the application site
  • dryness or flaking of the skin
  • flushing or redness of the skin
  • unusually warm skin

Incidence not known

  • Blistering, burning, or crusting of the skin
  • itching, scaling, severe redness, soreness, or swelling of the skin

For Healthcare Professionals

Applies to acyclovir / hydrocortisone topical: topical cream


The most frequently reported side effects were local skin reactions and included drying or flaking of the skin; burning or tingling; erythema; pigmentation changes; and application site reactions including signs/symptoms of inflammation.


Frequency not reported: Dry skin, flaking skin, burning, tingling, erythema, pigmentation changed, inflammation


Frequency not reported: Contact allergy, sensitization


Frequency not reported: Contact dermatitis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Xerese (www.drugs.com/xerese.html).