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Xalkori

Generic Name: crizotinib (kriz OH ti nib)
Brand Names: Xalkori
Xalkori (crizotinib) is used to treat non-small cell lung cancer. Includes Xalkori warnings, side effects, interactions and indications.
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Drug Information:
Xalkori (crizotinib) is a cancer medication that interferes with the growth and spread of cancer cells in the body. Xalkori is used to treat non-small cell lung cancer that has spread to other parts of the body. Xalkori may also be used for purposes not listed in this medication guide. Xalkori can cause serious heart or liver problems. Call your doctor at once if you have: fast or pounding heartbeats, sudden dizziness, shortness of breath, tiredness, itching, upper stomach pain, dark urine, Clay-colored stools, or jaundice (yellowing of the skin or eyes). Learn more

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Xalkori Side Effects

Note: This document contains side effect information about crizotinib. Some of the dosage forms listed on this page may not apply to the brand name Xalkori.

In Summary

Common side effects of Xalkori include: increased serum alanine aminotransferase. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to crizotinib: oral capsule

Along with its needed effects, crizotinib (the active ingredient contained in Xalkori) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking crizotinib:

More common

  • Black, tarry stools
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • body aches or pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • cough or hoarseness
  • difficult or labored breathing
  • ear congestion
  • fever or chills
  • headache
  • increased sensitivity to pain or touch
  • lightheadedness, dizziness, or fainting
  • loss of voice
  • lower back or side pain
  • nerve pain
  • painful or difficult urination
  • pale skin
  • rapid weight gain
  • runny or stuffy nose
  • slow or irregular heartbeat
  • sneezing
  • sore throat
  • tightness in the chest
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • weakness in the arms, hands, legs, or feet

Rare

  • Bleeding gums
  • blood in the urine or stools
  • pinpoint red spots on the skin

Some side effects of crizotinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach discomfort, pain, or tenderness
  • acid or sour stomach
  • back pain
  • belching
  • change in taste
  • decrease or change in vision
  • decreased appetite
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • difficulty with swallowing
  • heartburn
  • increased sensitivity of the eyes to sunlight
  • indigestion
  • muscle pain or stiffness
  • nausea
  • pain in the joints
  • pain or burning in the throat
  • pain or discomfort in the chest, upper stomach, or throat
  • problems with balance
  • rash
  • redness, swelling, or soreness of the tongue
  • scaling, redness, burning, pain, chapping, swelling, or other signs of inflammation of the lips
  • seeing flashes or sparks of light
  • swelling or inflammation of the mouth
  • trouble sleeping

For Healthcare Professionals

Applies to crizotinib: oral capsule

Ocular

Very common (10% or more): Vision disorders (e.g., diplopia, photophobia, photopsia, reduced visual acuity, blurred vision, vitreous floaters, visual impairment) (71%)

Uncommon (0.1% to 1%): Severe vision loss

Cardiovascular

Very common (10% or more): Bradycardia (14%)

Common (1% to 10%): QT interval prolongation, cardiac failure (e.g., cardiac failure, cardiac failure congestive, ejection fraction decreased, left ventricular failure, pulmonary edema), syncope

Hepatic

Very common (10% or more): ALT elevation (79%), AST elevation (66%)

Common (1% to 10%): Increased alkaline phosphatase, hepatic failure

Hematologic

Very common (10% or more): Neutropenia (22%), lymphopenia (18%), leukopenia (15%), anemia (15%)

Respiratory

Very common (10% or more): Upper respiratory infection (e.g., nasopharyngitis, pharyngitis, rhinitis, upper respiratory tract infection) (32%)

Common (1% to 10%): Pulmonary embolism, interstitial lung disease

Gastrointestinal

Very common (10% or more): Diarrhea (61%), nausea (57%), vomiting (46%), constipation (43%), abdominal pain (26%), dyspepsia (14%), dysphagia (10%)

Common (1% to 10%): Esophagitis

Dermatologic

Very common (10% or more): Rash (13%)

General

The most common adverse reactions (25% or more) are vision disorders, nausea, diarrhea, vomiting, constipation, edema, elevated transaminases, fatigue, decreased appetite, upper respiratory infection, dizziness, and neuropathy.

Metabolic

Very common (10% or more): Hypophosphatemia (32%), decreased appetite (27%), hypokalemia (18%), decreased weight (10%)

Common (1% to 10%): Decreased blood testosterone (e.g., blood testosterone decreased, hypogonadism, secondary hypogonadism)

Uncommon (0.1% to 1%): Increased weight

Nervous system

Very common (10% or more): Dysgeusia (26%), dizziness (e.g., balance disorder, dizziness, dizziness postural, presyncope) (26%), neuropathy (e.g., burning sensation, dysesthesia, formication, gait disturbance, hyperesthesia, hypoesthesia, hypotonia, motor dysfunction, muscle atrophy, muscular weakness, neuralgia, neuritis, neuropathy peripheral, neurotoxicity, paresthesia, peripheral motor neuropathy, peripheral sensorimotor neuropathy, peripheral sensory neuropathy, peroneal nerve palsy, polyneuropathy, sensory disturbance, skin burning sensation) (25%)

Other

swelling, localized edema, peripheral edema, periorbital edema (49%), fatigue (30%), pyrexia (19%)

Renal

Common (1% to 10%): Renal cyst (e.g., renal abscess, renal cyst, renal cyst hemorrhage, renal cyst infection)

Musculoskeletal

Very common (10% or more): Pain in extremity (16%)

Common (1% to 10%): Muscle spasm

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Xalkori (www.drugs.com/xalkori.html).