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Note: This document contains side effect information about crizotinib. Some of the dosage forms listed on this page may not apply to the brand name Xalkori.
Common side effects of Xalkori include: increased serum alanine aminotransferase. See below for a comprehensive list of adverse effects.
Applies to crizotinib: oral capsule
Along with its needed effects, crizotinib (the active ingredient contained in Xalkori) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking crizotinib:
Some side effects of crizotinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to crizotinib: oral capsule
Very common (10% or more): Vision disorders (e.g., diplopia, photophobia, photopsia, reduced visual acuity, blurred vision, vitreous floaters, visual impairment) (71%)
Uncommon (0.1% to 1%): Severe vision loss
Very common (10% or more): Bradycardia (14%)
Common (1% to 10%): QT interval prolongation, cardiac failure (e.g., cardiac failure, cardiac failure congestive, ejection fraction decreased, left ventricular failure, pulmonary edema), syncope
Very common (10% or more): ALT elevation (79%), AST elevation (66%)
Common (1% to 10%): Increased alkaline phosphatase, hepatic failure
Very common (10% or more): Neutropenia (22%), lymphopenia (18%), leukopenia (15%), anemia (15%)
Very common (10% or more): Upper respiratory infection (e.g., nasopharyngitis, pharyngitis, rhinitis, upper respiratory tract infection) (32%)
Common (1% to 10%): Pulmonary embolism, interstitial lung disease
Very common (10% or more): Diarrhea (61%), nausea (57%), vomiting (46%), constipation (43%), abdominal pain (26%), dyspepsia (14%), dysphagia (10%)
Common (1% to 10%): Esophagitis
Very common (10% or more): Rash (13%)
The most common adverse reactions (25% or more) are vision disorders, nausea, diarrhea, vomiting, constipation, edema, elevated transaminases, fatigue, decreased appetite, upper respiratory infection, dizziness, and neuropathy.
Very common (10% or more): Hypophosphatemia (32%), decreased appetite (27%), hypokalemia (18%), decreased weight (10%)
Common (1% to 10%): Decreased blood testosterone (e.g., blood testosterone decreased, hypogonadism, secondary hypogonadism)
Uncommon (0.1% to 1%): Increased weight
Very common (10% or more): Dysgeusia (26%), dizziness (e.g., balance disorder, dizziness, dizziness postural, presyncope) (26%), neuropathy (e.g., burning sensation, dysesthesia, formication, gait disturbance, hyperesthesia, hypoesthesia, hypotonia, motor dysfunction, muscle atrophy, muscular weakness, neuralgia, neuritis, neuropathy peripheral, neurotoxicity, paresthesia, peripheral motor neuropathy, peripheral sensorimotor neuropathy, peripheral sensory neuropathy, peroneal nerve palsy, polyneuropathy, sensory disturbance, skin burning sensation) (25%)
swelling, localized edema, peripheral edema, periorbital edema (49%), fatigue (30%), pyrexia (19%)
Common (1% to 10%): Renal cyst (e.g., renal abscess, renal cyst, renal cyst hemorrhage, renal cyst infection)
Very common (10% or more): Pain in extremity (16%)
Common (1% to 10%): Muscle spasm