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$95 – $998
In the Deductible co-pay stage, you are responsible for the full cost of your prescriptions. Your Medicare deductible cannot exceed $360 in 2016.
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Note: This document contains side effect information about lacosamide. Some of the dosage forms listed on this page may not apply to the brand name Vimpat.
In SummaryCommon side effects of Vimpat include: blurred vision, diplopia, dizziness, fatigue, headache, nausea, nystagmus disorder, tremor, vomiting, and ataxia. Other side effects include: abnormal gait, asthenia, memory impairment, and vertigo. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to lacosamide: oral solution, oral tablet
Other dosage forms:
Along with its needed effects, lacosamide (the active ingredient contained in Vimpat) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking lacosamide:
More common
Less common
Incidence not known
Some side effects of lacosamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Incidence not known
For Healthcare Professionals
Applies to lacosamide: intravenous solution, oral solution, oral tablet
GeneralThe most commonly reported adverse reactions have included diplopia, headache, dizziness, and nausea.
Nervous systemDizziness was reported in 25% of patients randomized to the recommended doses (200 to 400 mg/day) of this drug compared with 8% of placebo patients in studies in adult patients with partial-onset seizures taking 1 to 3 concomitant AEDs. It was the event most frequently leading to discontinuation (3%). Ataxia was reported by 6% of patients randomized to the recommended doses (200 to 400 mg/day) compared to 2% in placebo patients. Dizziness and ataxia were also observed in pediatric clinical trials.
Very common (10% or more): Dizziness (up to 60%), headache (up to 13%), ataxia (up to 15%)
Common (1% to 10%): Somnolence, tremor, balance disorder, nystagmus, memory impairment, coordination abnormal, cognitive disorder, somnolence, tremor, dysarthria, disturbance in attention, paresthesia
Frequency not reported: Oral hypoesthesia, pyrexia
Postmarketing reports: Hypoesthesia, cerebellar syndrome, new or worsening seizures
GastrointestinalVery common (10% or more): Nausea (up to 24%), vomiting (up to 16%)
Common (1% to 10%): Diarrhea, constipation, flatulence, dyspepsia, dry mouth
OcularVery common (10% or more): Diplopia (up to 16%), blurred vision (up to 16%)
HypersensitivityUncommon (0.1% to 1%): Hypersensitivity
Frequency not reported: Multiorgan hypersensitivity reactions (also known as Drug Reaction with Eosinophilia and Systemic Symptoms, or DRESS)
OtherVery common (10% or more): Fatigue (up to 15%)
Common (1% to 10%): Asthenia, vertigo, gait disturbance
Frequency not reported: Tinnitus, fall
LocalCommon (1% to 10%): Injection site pain or discomfort
Uncommon (0.1% to 1%): Irritation, erythema
PsychiatricCommon (1% to 10%): Depression, confusional state, insomnia
Uncommon (0.1% to 1%): Aggression, agitation, euphoric mood, suicide attempt, suicidal ideation, hallucination
Frequency not reported: Irritability, feeling drunk
Postmarketing reports: Psychotic disorder
DermatologicCommon (1% to 10%): Pruritus, rash
Uncommon (0.1% to 1%): Angioedema, urticaria
Frequency not reported: Neutropenia, anemia
Postmarketing reports: Stevens-Johnson syndrome, toxic epidermal necrolysis
CardiovascularDuring clinical trials in adult patients with partial-onset seizures, asymptomatic first-degree atrioventricular (AV) block was observed in 0.4% (4/944) of patients randomized to this drug and 0% (0/364) of placebo patients. One case of profound bradycardia was observed in a patient during a 15-minute 150 mg IV infusion.
In short-term trials in adult patients with diabetic neuropathy, atrial fibrillation occurred in 0.5% of patients (placebo=0%). Syncope occurred in 1.2% of patients (placebo=0%).
A clinical pharmacology study in healthy subjects (n=247) did not shown any QTc interval prolongation or dose-related or clinically important effects on QRS duration. This drug did produce a dose-related increase in mean PR interval; the maximum mean PR interval increase corresponded with Tmax. The placebo-subtracted maximum increase in PR interval was 7.3 ms for the 400 mg/day group and 11.9 ms for the 800 mg/day group. In clinical trials, the placebo-subtracted mean maximum increase in PR interval for a 400 mg/day dose was 3.1 ms in patients with partial-onset seizures and 9.4 ms for patients with diabetic neuropathy.
Very common (10% or more): Chest pain (up to 12%)
Common (1% to 10%): Syncope
Uncommon (0.1% to 1%): Atrioventricular block, bradycardia, atrial fibrillation, atrial flutter
Frequency not reported: Palpitations
Postmarketing reports: Cardiac arrhythmias including bradycardia, AV block, and ventricular tachyarrhythmia, which have rarely resulted in asystole, cardiac arrest, and death
MusculoskeletalCommon (1% to 10%): Muscle spasms
Frequency not reported: Connective tissue disorders
HematologicFrequency not reported: Neutropenia, anemia
Postmarketing reports: Agranulocytosis
HepaticUncommon (0.1% to 1%): Liver function test abnormal
Frequency not reported: Hepatitis
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Vimpat (www.drugs.com/vimpat.html).
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