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Viibryd Prescription
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Generic Name: vilazodone (vil AZ oh done)
Brand Names: Viibryd, Viibryd Starter
Viibryd (vilazodone) is a selective serotonin reuptake inhibitor (SSRI) and is used to treat major depressive disorder. Includes Viibryd side effects, interactions and indications.
Generic Name: vilazodone (vil AZ oh done)
Brand Names: Viibryd, Viibryd Starter
Viibryd (vilazodone) is a selective serotonin reuptake inhibitor (SSRI) and is used to treat major depressive disorder. Includes Viibryd side effects, interactions and indications.
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30 tablets of Viibryd 40 mg
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Viibryd Drug Information:

Viibryd (vilazodone) is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Viibryd is used to treat major depressive disorder (MDD). Viibryd may also be used for purposes not listed in this medication guide. Do not use Viibryd if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, Linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine, or if you have had a Methylene Blue injection. A dangerous drug interaction could occur. Learn more

Viibryd Side Effects

Note: This document contains side effect information about vilazodone. Some of the dosage forms listed on this page may not apply to the brand name Viibryd.

In Summary

Common side effects of Viibryd include: diarrhea and nausea. Other side effects include: dizziness, insomnia, and abnormal dreams. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to vilazodone: oral tablet


Oral route (Tablet)

Antidepressants can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults (24 years or younger). Closely monitor patients of all ages for clinical worsening and for emergence of suicidal thoughts and behaviors. The safety and efficacy of vilazodone hydrochloride have not been established in pediatric patients.

Along with its needed effects, vilazodone (the active ingredient contained in Viibryd) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vilazodone:

Less common

  • Actions that are out of control
  • anxiety
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • extra heartbeat
  • fast, irregular, pounding, or racing heartbeat or pulse
  • irritability
  • shakiness in the legs, arms, hands, or feet
  • sweating
  • talking, feeling, and acting with excitement
  • trembling or shaking of the hands or feet

Some side effects of vilazodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • dizziness
  • dry mouth
  • nausea
  • trouble sleeping

Less common

  • Abdominal or stomach pain
  • abnormal dreams
  • aching or discomfort in the lower legs or sensation of crawling in the legs
  • acid or sour stomach
  • belching
  • blindness
  • bloated or full feeling
  • blurred vision
  • change in taste
  • decreased interest in sexual intercourse
  • decreased vision
  • difficulty with moving
  • drowsiness
  • dry eyes
  • excess air or gas in the stomach or intestines
  • feeling jittery
  • headache, severe and throbbing
  • heartburn
  • inability to have or keep an erection
  • increased or decreased appetite
  • increased sweating
  • indigestion
  • loss in sexual ability, desire, drive, or performance
  • loss of appetite
  • loss of taste
  • muscle pain or stiffness
  • night sweats
  • not able to have an orgasm
  • pain in the joints
  • passing gas
  • relaxed and calm
  • restlessness
  • sleepiness or unusual drowsiness
  • stomach discomfort or upset
  • unusual tiredness or weakness
  • vomiting
  • weakness

Incidence not known

  • Eye pain

For Healthcare Professionals

Applies to vilazodone: oral kit, oral tablet


The most commonly observed side effects were: diarrhea, nausea, headache, and dry mouth.


Very common (10% or more): Diarrhea (up to 29%), nausea (up to 24%)

Common (1% to 10%): Abdominal distension, abdominal pain, pain, dry mouth, dyspepsia, flatulence, gastroenteritis, vomiting

Frequency not reported: Abdominal discomfort, acute pancreatitis, upper abdominal pain

Nervous system

Very common (10% or more): Headache (up to 15%)

Common (1% to 10%): Dizziness, paresthesia, sedation, somnolence, tremor

Uncommon (0.1% to 1%): Migraine, serotonin syndrome

Frequency not reported: Akathisia, paresthesia/electric shock sensation, restless legs syndrome, sensory disturbances

Postmarketing reports: Sleep paralysis


Common (1% to 10%): Abnormal dreams, abnormal orgasm, decreased libido, insomnia, restlessness

Uncommon (0.1% to 1%): Activation of mania/hypomania, panic attack

Frequency not reported: Agitation, anorgasmia, anxiety, clinical worsening, confusion, discontinuation symptoms, dysphoric mood, emotional lability, lethargy, seizures, suicide risk

Postmarketing reports: Irritability, hallucinations, suicide attempt, suicidal ideation


Common (1% to 10%): Increased appetite, increased weight

Frequency not reported: Hyponatremia


Common (1% to 10%): Ejaculation disorder, erectile dysfunction


Common (1% to 10%): Palpitations

Uncommon (0.1% to 1%): Ventricular extrasystoles


Common (1% to 10%): Fatigue

Uncommon (0.1% to 1%): Tinnitus


Common (1% to 10%): Arthralgia


Uncommon (0.1% to 1%): Blurred vision, dry eye

Rare (0.01% to 0.1%): Cataracts


Uncommon (0.1% to 1%): Hyperhidrosis, night sweats

Postmarketing reports: Drug eruption, generalized rash, rash, urticaria


Frequency not reported: Abnormal Bleeding

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Viibryd (www.drugs.com/viibryd.html).