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Commonly reported side effects of verapamil include: sinus bradycardia. Other side effects include: pulmonary edema, severe hypotension, and second degree atrioventricular block. See below for a comprehensive list of adverse effects.For the Consumer
Applies to verapamil: oral capsule extended release, oral tablet, oral tablet extended release
Other dosage forms:
Along with its needed effects, verapamil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking verapamil:
Some side effects of verapamil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For Healthcare Professionals
Applies to verapamil: compounding powder, intravenous solution, oral capsule extended release, oral tablet, oral tablet extended releaseGeneral
The most commonly reported side effects include constipation, dizziness, and headache.Nervous system
Seizures occurred rarely with IV administration.
Paralysis/tetraparesis was reported in a patient taking this drug and colchicine concurrently.
Very common (10% or more): Headache (up to 12.1%)
Common (1% to 10%): Dizziness, lethargy
Rare (0.01% to 0.1%): Seizures
Frequency not reported: Rotary nystagmus, sleepiness, vertigo, lightheadedness, tingling, numbness, neuropathy
Postmarketing reports: Syncope, cerebrovascular accident, equilibrium disorders, parkinsonism/extrapyramidal symptoms/syndrome, paresthesia, shakiness/tremor, paralysis/tetraparesis, somnolenceCardiovascular
Cardiovascular side effects may occur with greater intensity at higher doses or in patients with a history of myocardial damage.
Approximately 15% of patients who had atrial flutter/fibrillation and received this drug and digoxin developed resting ventricular rates below 50 beats/min; in the same trial, asymptomatic hypotension occurred in approximately 5% of patients.
Asystole occurred after second/third degree AV block and was usually short in duration, with spontaneous cardiac action returning within seconds in the form of a sinus rhythm.
Common (1% to 10%): Symptomatic hypotension/hypotension/abrupt blood pressure fall, sinus bradycardia/bradycardia (heart rate less than 50 beats/minute), severe tachycardia, ankle edema/edema, development/aggravation of congestive heart failure (CHF), atrioventricular (AV) block, peripheral edema
Uncommon (0.1% to 1%): Second-/third-degree AV block, palpitations, orthostasis
Postmarketing reports: Angina pectoris/chest pain, AV dissociation, ECG abnormal, claudication, hypertension, myocardial infarction, sinus arrest with asystole, decreased myocardial contractility, cardiogenic shock, bradyarrhythmia in atrial fibrillation, vasculitis, erythromelalgiaGastrointestinal
Non-obstructive paralytic ileus was reversible when treatment was stopped.
Gingival hyperplasia occurred when this drug was given over a prolonged period of time, and was reversible once the drug was discontinued.
Common (1% to 10%): Constipation, dyspepsia, nausea, diarrhea, flatulence
Uncommon (0.1% to 1%): Abdominal discomfort/pain
Frequency not reported: Non-obstructive paralytic ileus/ileus, bloating
Postmarketing reports: Dry mouth, gastrointestinal stress, gingival hyperplasia, vomitingRespiratory
Bronchospasm and laryngeal spasm occurred during hypersensitivity reactions.
Common (1% to 10%): Pulmonary edema, pharyngitis, sinusitis, rhinitis, dyspnea
Rare (0.01% to 0.1%): Broncho/laryngeal spasmOther
Common (1% to 10%): Fatigue, tiredness/malaise, accidental injury, pain
Frequency not reported: Infection, flu syndrome
Postmarketing reports: Tinnitus, astheniaDermatologic
Common (1% to 10%): Scalp irritation, rash
Uncommon (0.1% to 1%): Itching, urticaria, flushing, exanthema
Frequency not reported: Diaphoresis, photodermatitis
Postmarketing reports: Ecchymosis, bruising, alopecia/hair loss, hyperkeratosis, macules, Stevens-Johnson syndrome, hyperhidrosis/sweating, erythema multiforme, Quincke's edema/angioneurotic edema
Itch and urticaria occurred in hypersensitivity reactions.Psychiatric
Common (1% to 10%): Sleep disturbance
Uncommon (0.1% to 1%): Bad dreams, depression/emotional depression
Postmarketing reports: Confusion, psychotic symptoms, insomnia, nervousnessMusculoskeletal
Common (1% to 10%): Myalgia
Frequency not reported: Muscle fatigue
Postmarketing reports: Muscle cramps, arthralgiaHepatic
Reversible elevations liver enzymes occurred during treatment, and are likely the result of a hypersensitivity reaction (e.g., allergic hepatitis).
Uncommon (0.1% to 1%): Elevated liver enzymes (transaminases, alkaline phosphatase)Hypersensitivity
Rare (0.01% to 0.1%): Hypersensitivity/allergic reactions
Postmarketing reports: Allergy aggravatedMetabolic
Frequency not reported: Lowered glucose tolerance
Postmarketing reports: HyperkalemiaGenitourinary
Postmarketing reports: Galactorrhea, increased blood prolactin/hyperprolactinemia, increased urination, spotty menstruation, erectile dysfunction/impotenceRenal
Postmarketing reports: Renal failureEndocrine
Gynecomastia occurred in older male patients on prolonged treatment, and was reversible upon discontinuation of this drug.
Postmarketing reports: GynecomastiaHematologic
Postmarketing reports: PurpuraOcular
Postmarketing reports: Blurred vision
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