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Venclexta Prescription
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Generic Name: venetoclax (ven ET oh klax)
Brand Names: Venclexta
Venclexta information from Drugs.com, includes Venclexta side effects, interactions and indications.
Generic Name: venetoclax (ven ET oh klax)
Brand Names: Venclexta
Venclexta information from Drugs.com, includes Venclexta side effects, interactions and indications.
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30 tablets of Venclexta 40 mg
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Venclexta Drug Information:

Venclexta (venetoclax) inhibits a certain protein in cancer cells (abnormal lymphocytes produced in chronic lymphocytic leukemia) that helps keep those cells alive and makes them resistant to chemotherapy. Venetoclax binds to this protein, which helps kill the cancerous lymphocytes in blood and bone marrow. Venclexta is used to treat chronic lymphocytic leukemia (CLL) or small lymphocytic leukemia (SLL) in adults with or without 17p deletion (a specific genetic marker). Venclexta is sometimes used in combination with rituximab to treat these conditions. Learn more

Venclexta Side Effects

Note: This document contains side effect information about venetoclax. Some of the dosage forms listed on this page may not apply to the brand name Venclexta.

In Summary

Common side effects of Venclexta include: tumor lysis syndrome and neutropenia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to venetoclax: oral tablet

Along with its needed effects, venetoclax (the active ingredient contained in Venclexta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking venetoclax:

More common

  • Black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • body aches or pain
  • chest pain
  • decreased urine
  • dry mouth
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea
  • numbness or tingling in the hands, feet, or lips
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • seizures
  • tightness in the chest
  • tingling of the hands or feet
  • troubled breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting

Incidence not known

  • Chills
  • cough
  • ear congestion
  • fever
  • joint pain, stiffness, or swelling
  • lower back or side pain
  • nasal congestion
  • painful or difficult urination
  • runny nose
  • sneezing
  • sore throat
  • stomach pain
  • ulcers, sores, or white spots in the mouth

Some side effects of venetoclax may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • diarrhea
  • difficulty having a bowel movement

For Healthcare Professionals

Applies to venetoclax: oral kit, oral tablet


Very common (10% or more): Diarrhea (35%), nausea (33%), vomiting (15%), constipation (14%)


The most common adverse reactions (20% or greater) of any grade were neutropenia, diarrhea, nausea, anemia, upper respiratory tract infection, thrombocytopenia, and fatigue.


Very common (10% or more): Neutropenia (45%), anemia (29%), thrombocytopenia (22%)

Common (1% to 10%): Febrile neutropenia

Frequency not reported: Autoimmune hemolytic anemia


Very common (10% or more): Hyperkalemia (20%), hyperphosphatemia (15%), hypokalemia (12%)

Common (1% to 10%): Tumor lysis syndrome, hypocalcemia, hyperuricemia


Very common (10% or more): Back pain (10%)

Nervous system

Very common (10% or more): Headache (15%)


Very common (10% or more): Fatigue (21%), pyrexia (16%), peripheral edema (11%)


Very common (10% or more): Upper respiratory tract infection (22%), cough (13%)

Common (1% to 10%): Pneumonia

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Venclexta (www.drugs.com/venclexta.html).