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Vaseretic

Generic Name: hydrochlorothiazide and enalapril (HYE droe KLOR oh THYE a zide and en AL e pril)
Brand Name: Vaseretic 10-25
Physician reviewed Vaseretic 10-25 patient information - includes Vaseretic 10-25 description, dosage and directions.

Average Savings for enalapril maleate/hydroch (generic): 26.23%
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Drug Information:
HydroChlorothiazide is a thiazide diuretic (water pill) and enalapril is an ACE inhibitor (ACE stands for angiotensin converting enzyme). Vaseretic 10-25 is a combination medicine used to treat hypertension (high blood pressure). Vaseretic 10-25 may also be used for purposes not listed in this medication guide. Do not use if you are pregnant. If you become pregnant, stop taking Vaseretic 10-25 and tell your doctor right away. You should not use this medicine if you are unable to urinate, if you have ever had angioedema, or if you are allergic to sulfa drugs or any ACE inhibitor. Do not take Vaseretic 10-25 within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). Learn more

Vaseretic Side Effects

Vaseretic Side Effects

Note: This document contains side effect information about enalapril / hydrochlorothiazide. Some of the dosage forms listed on this page may not apply to the brand name Vaseretic.

In Summary

Common side effects of Vaseretic include: increased blood urea nitrogen and increased serum creatinine. Other side effects include: dizziness and headache. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to enalapril / hydrochlorothiazide: oral tablet

Warning

Oral route (Tablet)

Discontinue enalapril maleate/hydrochlorothiazide as soon as possible when pregnancy is detected, since fetal toxicity, including injury and death to the developing fetus, can be caused by drugs that act directly on the renin-angiotensin system.

Along with its needed effects, enalapril / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking enalapril / hydrochlorothiazide:

Less common

  • Blurred vision
  • chest pain or discomfort
  • chills
  • cold sweats
  • coma
  • confusion
  • decreased urine output
  • diarrhea
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • fainting
  • fast, slow, or irregular heartbeat
  • headache
  • increased thirst
  • irritability
  • loss of appetite
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • rapid breathing
  • seizures
  • sunken eyes
  • sweating
  • swelling of the face, ankles, or hands
  • thirst
  • unusual tiredness or weakness
  • weak pulse
  • wrinkled skin

Some side effects of enalapril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Cough
  • decreased interest in sexual intercourse
  • inability to have or keep an erection
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance

For Healthcare Professionals

Applies to enalapril / hydrochlorothiazide: oral tablet

General

The most common adverse reactions were dizziness, headache, fatigue, and cough.

Nervous system

Common (1% to 10%): Dizziness, headache, syncope

Frequency not reported: Paresthesia, somnolence, vertigo, tinnitus

Enalapril:

Postmarketing reports: Cerebrovascular accident, ataxia, peripheral neuropathy, paresthesia, dysesthesia, taste alteration, anosmia

Other

Common (1% to 10%): Fatigue, asthenia, orthostatic effects

Frequency not reported: Chest pain

Enalapril:

Postmarketing reports: Gynecomastia

Hydrochlorothiazide:

Frequency not reported: Weakness, fever

Respiratory

Common (1% to 10%): Cough

Frequency not reported: Dyspnea

Enalapril:

Postmarketing reports: Pulmonary embolism and infarction, pulmonary edema

Hydrochlorothiazide:

Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema

Musculoskeletal

Common (1% to 10%): Muscle cramps

Frequency not reported: Back pain, arthralgia

Enalapril:

Postmarketing reports: Flank pain

Hydrochlorothiazide:

Frequency not reported: Muscle spasm

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea

Frequency not reported: Abdominal pain, vomiting, dyspepsia, constipation, flatulence, dry mouth

Enalapril:

Postmarketing reports: Ileus, pancreatitis, melena, glossitis, stomatitis, dry mouth

Hydrochlorothiazide:

Frequency not reported: Pancreatitis, sialadenitis, cramping, gastric irritation

Genitourinary

Common (1% to 10%): Impotence

Frequency not reported: Urinary tract infection

Enalapril:

Postmarketing reports: Oliguria

Cardiovascular

Common (1% to 10%): Orthostatic hypotension

Uncommon (0.1% to 1%): Hypotension

Frequency not reported: Palpitation, tachycardia

Enalapril:

Postmarketing reports: Cardiac arrest, myocardial infarction, rhythm disturbances, atrial tachycardia and bradycardia, atrial fibrillation, hypotension, angina pectoris, Raynaud's phenomenon, flushing

Hydrochlorothiazide:

Frequency not reported: Vasculitis

Renal

Uncommon (0.1% to 1%): BUN increased, serum creatinine increased

Enalapril:

Postmarketing reports: Renal failure, renal dysfunction, pulmonary infiltrates, eosinophilic pneumonitis, bronchospasm, pneumonia, bronchitis, rhinorrhea, sore throat and hoarseness, asthma, upper respiratory infection

Hydrochlorothiazide:

Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis

Dermatologic

Frequency not reported: Pruritus, rash, diaphoresis, angioedema

Enalapril:

Postmarketing reports: Exfoliative dermatitis, toxic epidermal necrolysis, Stevens-Johnson syndrome, herpes zoster, erythema multiforme, urticaria, pemphigus, alopecia, photosensitivity

Hydrochlorothiazide:

Frequency not reported: Purpura, photosensitivity, urticaria, cutaneous vasculitis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, alopecia

Psychiatric

Frequency not reported: Insomnia, nervousness, libido decreased

Enalapril:

Postmarketing reports: Depression, confusion, dream abnormality

Hydrochlorothiazide:

Frequency not reported: Restlessness

Hematologic

Frequency not reported: Hemoglobin decreased, hematocrit decreased

Enalapril:

Postmarketing reports: Neutropenia, thrombocytopenia, bone marrow depression, hemolytic anemia

Hydrochlorothiazide:

Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia

Hepatic

Frequency not reported: Liver enzymes increased, serum bilirubin increased

Enalapril:

Postmarketing reports: Hepatic failure, hepatitis

Hydrochlorothiazide:

Frequency not reported: Intrahepatic cholestatic jaundice

Metabolic

Frequency not reported: Gout

Postmarketing reports: Anorexia

Hydrochlorothiazide:

Frequency not reported: Anorexia

Ocular

Enalapril:

Postmarketing reports: Blurred vision, conjunctivitis, dry eyes, tearing

Hydrochlorothiazide:

Frequency not reported: Transient blurred vision, xanthopsia

Immunologic

Enalapril:

Postmarketing reports: Anaphylactoid reactions

Hydrochlorothiazide:

Frequency not reported: Anaphylactic reactions

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Vaseretic (www.drugs.com/mtm/vaseretic-10-25.html).