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Valacyclovir hydrochlorid

Generic Name: valacyclovir (val a SYE kloe veer)
Brand Names: Valtrex
Valacyclovir is used to treat genital herpes, cold sores, shingles, and chicken pox. Learn about side effects, interactions and indications.

Average Savings for valacyclovir hydrochlorid (generic): 68.76%
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Drug Information:
ValAcyclovir is an antiviral drug. It slows the growth and spread of the herpes virus to help the body fight the infection. ValAcyclovir is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles (herpes zoster) in adults. ValAcyclovir is used to treat cold sores in children who are at least 12 years old, or chickenpox in children who are at least 2 years old. ValAcyclovir will not cure herpes and will not prevent you from spreading the virus to other people. However, this medicine can lessen the symptoms of an infection. Learn more

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Valacyclovir hydrochlorid Side Effects

For the Consumer

Applies to valacyclovir: oral tablet

Along with its needed effects, valacyclovir may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking valacyclovir:

More common

  • Discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • tiredness
  • trouble concentrating
  • trouble sleeping

Rare

  • Black, tarry stools
  • chest pain
  • chills
  • cough
  • decreased frequency or output of urine
  • fever
  • flu-like symptoms
  • headache
  • lower back or side pain
  • reduced mental alertness
  • shortness of breath
  • yellow eyes or skin

Incidence not known

  • Actions that are out of control
  • agitation
  • anxiety
  • back, leg, or stomach pains
  • bleeding gums
  • blood in urine or stools
  • blurred vision
  • change in consciousness
  • change in mental status
  • changes in behavior, especially in interactions with other people
  • changes in patterns and rhythms of speech
  • dark or bloody urine
  • difficult or labored breathing
  • difficulty speaking
  • difficulty swallowing
  • dizziness
  • drowsiness
  • dry mouth
  • fast, pounding, or irregular heartbeat or pulse
  • feeling that others are watching you or controlling your behavior
  • feeling that others can hear your thoughts
  • feeling, seeing, or hearing things that are not there
  • general tiredness and weakness
  • hyperventilation
  • increased thirst
  • itching
  • lightheadedness when getting up from a lying or sitting position
  • light-colored stools
  • loss of consciousness
  • mood or mental changes
  • nausea and vomiting
  • nervousness
  • pale color of skin
  • pinpoint red spots on the skin
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • seizures
  • severe mood or mental changes
  • shakiness and unsteady walk
  • shakiness in the legs, arms, hands, or feet
  • skin rash
  • slurred speech
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiff neck
  • swelling of the face, fingers, or lower legs
  • swollen or painful glands
  • talking, feeling, and acting with excitement
  • tightness in the chest
  • trembling or shaking of the hands or feet
  • trouble in speaking
  • troubled breathing
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual behavior
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right abdominal pain
  • vomiting
  • weight gain
  • wheezing

Some side effects of valacyclovir may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • cramps
  • difficulty in moving
  • ear congestion
  • heavy bleeding
  • loss of voice
  • muscle aches
  • muscle pain or stiffness
  • nasal congestion
  • pain
  • pain in joints
  • sneezing
  • sore throat
  • stuffy or runny nose

Less common

  • Constipation
  • diarrhea

Incidence not known

  • Blistering, peeling, or loosening of the skin
  • hair loss or thinning of the hair
  • hives or welts
  • increased sensitivity of skin to sunlight
  • red, irritated eyes
  • redness or other discoloration of the skin
  • severe sunburn

For Healthcare Professionals

Applies to valacyclovir: oral tablet

Gastrointestinal

Very common (10% or more): Nausea (up to 16%)

Common (1% to 10%): Vomiting, constipation, anorexia, dyspepsia, dry mouth, flatulence

Frequency not reported: Tooth disorder

Postmarketing reports: Diarrhea

Nervous system

Very common (10% or more): Headache (up to 16%)

Common (1% to 10%): Dizziness, somnolence

Frequency not reported: Migraine

Postmarketing reports: Seizures, tremors, ataxia, coma, dysarthria, encephalopathy

Neurologic/psychiatric events, sometimes severe, have included confusion, agitation, convulsions, hallucinations, and coma have generally been reversible with discontinuation. These events have mostly been seen in patients with renal impairment or in patients receiving higher doses.

Psychiatric

Neurologic/psychiatric events, sometimes severe, have included confusion, agitation, convulsions, hallucinations, and coma have generally been reversible with discontinuation. These events have mostly been seen in patients with renal impairment or in patients receiving higher doses.

Common (1% to 10%): Depression, insomnia

Postmarketing reports: Aggressive behavior, agitation, confusion, mania, psychosis, auditory and visual hallucinations

Renal

Uncommon (0.1% to 1%): Increased serum creatinine

Frequency not reported: Acute renal failure

Postmarketing reports: Renal failure, renal pain

Hematologic

TTP/HUS, including some fatalities, has been reported during clinical trials in patients with advanced HIV disease and in allogeneic bone marrow transplant and renal transplant recipients, who were receiving 8 g per day.

Common (1% to 10%): Decreased neutrophil counts, decreased platelet counts

Uncommon (0.1% to 1%): Decreased hemoglobin

Frequency not reported: Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome

Postmarketing reports: Thrombocytopenia, aplastic anemia, leukocytoclastic vasculitis

Hepatic

Common (1% to 10%): Abnormal ALT, elevated alkaline phosphatase, elevated AST

Postmarketing reports: Hepatitis

Hypersensitivity

Postmarketing reports: Acute hypersensitivity reactions including anaphylaxis, angioedema, dyspnea, pruritus, rash, urticaria

Dermatologic

Common (1% to 10%): Rash

Frequency not reported: Acne, pruritus

Postmarketing reports: Facial edema, erythema multiforme, photosensitivity, alopecia

Cardiovascular

Postmarketing reports: Hypertension, tachycardia

Ocular

Postmarketing reports: Visual abnormalities

Respiratory

Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection, rhinitis, pharyngitis

Uncommon (0.1% to 1%): Dyspnea

Frequency not reported: Sinusitis, bronchitis

Musculoskeletal

Common (1% to 10%): Arthralgia

Uncommon (0.1% to 1%): Back pain

Genitourinary

Frequency not reported: Dysmenorrhea, urinary tract infection

Other

Common (1% to 10%): Fatigue, asthenia, fever, chills

General

The most commonly reported adverse reactions have been headache, nausea, and abdominal pain.

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Valacyclovir Hydrochlorid (www.drugs.com/valacyclovir.html).

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