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Applies to valacyclovir: oral tablet
Along with its needed effects, valacyclovir may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking valacyclovir:
Incidence not known
Some side effects of valacyclovir may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
For Healthcare Professionals
Applies to valacyclovir: oral tabletGastrointestinal
Very common (10% or more): Nausea (up to 16%)
Common (1% to 10%): Vomiting, constipation, anorexia, dyspepsia, dry mouth, flatulence
Frequency not reported: Tooth disorder
Postmarketing reports: DiarrheaNervous system
Very common (10% or more): Headache (up to 16%)
Common (1% to 10%): Dizziness, somnolence
Frequency not reported: Migraine
Postmarketing reports: Seizures, tremors, ataxia, coma, dysarthria, encephalopathy
Neurologic/psychiatric events, sometimes severe, have included confusion, agitation, convulsions, hallucinations, and coma have generally been reversible with discontinuation. These events have mostly been seen in patients with renal impairment or in patients receiving higher doses.Psychiatric
Neurologic/psychiatric events, sometimes severe, have included confusion, agitation, convulsions, hallucinations, and coma have generally been reversible with discontinuation. These events have mostly been seen in patients with renal impairment or in patients receiving higher doses.
Common (1% to 10%): Depression, insomnia
Postmarketing reports: Aggressive behavior, agitation, confusion, mania, psychosis, auditory and visual hallucinationsRenal
Uncommon (0.1% to 1%): Increased serum creatinine
Frequency not reported: Acute renal failure
Postmarketing reports: Renal failure, renal painHematologic
TTP/HUS, including some fatalities, has been reported during clinical trials in patients with advanced HIV disease and in allogeneic bone marrow transplant and renal transplant recipients, who were receiving 8 g per day.
Common (1% to 10%): Decreased neutrophil counts, decreased platelet counts
Uncommon (0.1% to 1%): Decreased hemoglobin
Frequency not reported: Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome
Postmarketing reports: Thrombocytopenia, aplastic anemia, leukocytoclastic vasculitisHepatic
Common (1% to 10%): Abnormal ALT, elevated alkaline phosphatase, elevated AST
Postmarketing reports: HepatitisHypersensitivity
Postmarketing reports: Acute hypersensitivity reactions including anaphylaxis, angioedema, dyspnea, pruritus, rash, urticariaDermatologic
Common (1% to 10%): Rash
Frequency not reported: Acne, pruritus
Postmarketing reports: Facial edema, erythema multiforme, photosensitivity, alopeciaCardiovascular
Postmarketing reports: Hypertension, tachycardiaOcular
Postmarketing reports: Visual abnormalitiesRespiratory
Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection, rhinitis, pharyngitis
Uncommon (0.1% to 1%): Dyspnea
Frequency not reported: Sinusitis, bronchitisMusculoskeletal
Common (1% to 10%): Arthralgia
Uncommon (0.1% to 1%): Back painGenitourinary
Frequency not reported: Dysmenorrhea, urinary tract infectionOther
Common (1% to 10%): Fatigue, asthenia, fever, chillsGeneral
The most commonly reported adverse reactions have been headache, nausea, and abdominal pain.
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