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Uptravi Prescription
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Generic Name: selexipag (se LEX i pag)
Brand Names: Uptravi
Uptravi (selexipag) is used to treat pulmonary arterial hypertension. Includes Uptravi side effects, interactions and indications.
Generic Name: selexipag (se LEX i pag)
Brand Names: Uptravi
Uptravi (selexipag) is used to treat pulmonary arterial hypertension. Includes Uptravi side effects, interactions and indications.
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30 tablets of Uptravi 40 mg
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Offers Claimed: 59

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Uptravi Drug Information:

Uptravi (selexipag) lowers blood pressure in your lungs by dilating (widening) blood vessels that supply blood to the lungs. Uptravi is used to treat pulmonary arterial hypertension (PAH). Uptravi helps keep your condition from getting worse and helps lower your risk of needing to be hospitalized for PAH. Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together. You should not use Uptravi if you are allergic to selexipag. Learn more

Uptravi Side Effects

Note: This document contains side effect information about selexipag. Some of the dosage forms listed on this page may not apply to the brand name Uptravi.

In Summary

Common side effects of Uptravi include: diarrhea, headache, jaw pain, limb pain, myalgia, nausea, vomiting, and flushing. Other side effects include: anemia, and decreased appetite. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to selexipag: oral tablet

Along with its needed effects, selexipag (the active ingredient contained in Uptravi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking selexipag:

Incidence not known

  • Blue lips and fingernails
  • chest pain
  • coughing that sometimes produces a pink frothy sputum
  • difficult, fast, noisy breathing
  • increased sweating
  • pale skin
  • swelling in the legs and ankles

Some side effects of selexipag may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Decreased appetite
  • diarrhea
  • feeling of warmth
  • headache
  • joint pain
  • muscle aching or cramping
  • muscle pains or stiffness
  • nausea
  • pain in the jaw, arms, or legs
  • rash
  • redness of the face, neck, arms, and occasionally, upper chest
  • swollen joints
  • vomiting

For Healthcare Professionals

Applies to selexipag: oral tablet


The most frequently reported side effects included headache, diarrhea, jaw pain, nausea, myalgia, vomiting, pain in extremity, and flushing.

Nervous system

Very common (10% or more): Headache (up to 65%)

Frequency not reported: Burning sensation


Very common (10% or more): Diarrhea (up to 42%), nausea (up to 34%), vomiting (up to 18%)

Common (1% to 10%): Abdominal pain, dyspepsia, abdominal discomfort

Frequency not reported: Ascites


Very common (10% or more): Jaw pain (26%), pain in extremity (up to 17%), myalgia (up to 16%), arthralgia (up to 11%)

Common (1% to 10%): Musculoskeletal pain, neck pain

Frequency not reported: Bone pain


Very common (10% or more): Flushing (up to 12%), sinus tachycardia (up to 11.3%)

Common (1% to 10%): Hypotension

Frequency not reported: Hot flush


Very common (10% or more): Rash (11%)

Common (1% to 10%): Urticaria, erythema


Very common (10% or more): Nasopharyngitis (13%)

Common (1% to 10%): Nasal congestion

Frequency not reported: Pulmonary veno-occlusive disease


Common (1% to 10%): Hyperthyroidism, thyroid stimulating hormone decreased


Common (1% to 10%): Anemia, hemoglobin decreased


Common (1% to 10%): Appetite decreased


Common (1% to 10%): Eye pain, retinal disorder


Common (1% to 10%): Malignancy


Common (1% to 10%): Asthenia, pyrexia, pain, influenza, weight decreased


Frequency not reported: Acute renal failure

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Uptravi (www.drugs.com/uptravi.html).