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Generic Name: abaloparatide (a BAL oh PAR a tide)
Brand Names: Tymlos
Tymlos (abaloparatide) is used to treat osteoporosis in postmenopausal women who have a high risk of bone fracture. Tymlos increases bone mineral density and bone strength, which may prevent fractures.
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Drug Information:
Tymlos (abaloparatide) is a man-made form of paraThyroid hormone that exists naturally in the body. Abaloparatide increases bone mineral density and bone strength, which may prevent fractures. Tymlos is used to treat osteoporosis in postmenopausal women who have a high risk of bone fracture. Tymlos may also be used for purposes not listed in this medication guide. Tymlos has caused bone cancer (osteosarcoma) in animals but it is not known whether this would occur in people using this medicine. Talk with your doctor about your own risk. Learn more

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Tymlos Side Effects

Note: This document contains side effect information about abaloparatide. Some of the dosage forms listed on this page may not apply to the brand name Tymlos.

In Summary

Common side effects of Tymlos include: dizziness and hypercalciuria. Other side effects include: nausea and palpitations. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to abaloparatide: subcutaneous solution


Subcutaneous route (Solution)

Risk of Osteosarcoma: Abaloparatide caused a dose-dependent increase in the incidence of osteosarcoma, a malignant bone tumor, in male and female rats. It is unknown whether abaloparatide will cause osteosarcoma in humans. Use of abaloparatide is not recommended in patients at increased risk of osteosarcoma. Cumulative use of abaloparatide and parathyroid hormone analogs (eg, teriparatide) for more than 2 years during a patient’s lifetime is not recommended.

Along with its needed effects, abaloparatide (the active ingredient contained in Tymlos) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking abaloparatide:

More common

  • Blood in urine
  • constipation
  • depression
  • loss of appetite
  • loss of weight
  • muscle weakness
  • nausea or vomiting
  • pain in the side, back, or stomach
  • thirst
  • unusual tiredness or weakness

Less common

  • Fast, irregular, pounding, or racing heartbeat or pulse

Some side effects of abaloparatide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • dizziness
  • headache

Less common

  • Feeling of constant movement of self or surroundings
  • sensation of spinning

For Healthcare Professionals

Applies to abaloparatide: subcutaneous solution


Very common (10% or more): Common (1% to 10%): Orthostatic hypotension, tachycardia (e.g., sinus tachycardia), palpitations


Very common (10% or more): Immunogenicity


Very common (10% or more): Injection site redness (58%), injection site edema (10%)

Common (1% to 10%): Injection site pain


Common (1% to 10%): Nausea, upper abdominal pain


Very common (10% or more): Increased serum uric acid (25%)

Common (1% to 10%): Hypercalcemia


Very common (10% or more): Hypercalciuria (20%)

Common (1% to 10%): Urolithiasis

Nervous system

Very common (10% or more): Dizziness (10%)

Common (1% to 10%): Headache, vertigo

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Tymlos (www.drugs.com/tymlos.html).