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Note: This document contains side effect information about plecanatide. Some of the dosage forms listed on this page may not apply to the brand name Trulance.In Summary
More frequent side effects include: diarrhea. See below for a comprehensive list of adverse effects.For the Consumer
Applies to plecanatide: oral tablet
Oral route (Tablet)
Plecanatide is contraindicated in patients less than 6 years of age; in nonclinical studies in young juvenile mice administration of a single oral dose of plecanatide caused deaths due to dehydration. Avoid use of plecanatide in patients 6 years to less than 18 years of age. The safety and effectiveness of plecanatide have not been established in patients less than 18 years of age.
Along with its needed effects, plecanatide (the active ingredient contained in Trulance) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking plecanatide:
Some side effects of plecanatide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For Healthcare Professionals
Applies to plecanatide: oral tabletGastrointestinal
Common (1% to 10%): Diarrhea
Frequency not reported: Abdominal distention, flatulence, abdominal tendernessHepatic
In clinical trials, there were 2 patients with ALT greater than 5 to 15 times the upper limit of normal (ULN) and 3 patients with AST greater than 5 x ULN.
Frequency not reported: Increased liver biochemical testsRespiratory
Frequency not reported: Sinusitis, upper respiratory tract infection
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