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Applies to trimethoprim: oral solution, oral tablet
Along with its needed effects, trimethoprim may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking trimethoprim:
Some side effects of trimethoprim may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to trimethoprim: compounding powder, oral solution, oral tablet
The most common side effects were pruritus, rash, and mild gastrointestinal disturbances (including nausea, vomiting, glossitis); these effects were generally mild and reversed quickly when the drug was stopped.
Very common (10% or more): Hyperkalemia
Very rare (less than 0.01%): Hypoglycemia, hyponatremia, anorexia
Hyperkalemia has been reported, particularly in elderly patients and patients with HIV.
Common (1% to 10%): Rash (e.g., maculopapular, morbilliform, pruritic), urticaria
Very rare (less than 0.01%): Photosensitivity, angioedema, exfoliative dermatitis, fixed drug eruption, erythema multiforme, erythema nodosum, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's Syndrome), bullous dermatitis, purpura, allergic vasculitis (resembling Henoch-Schonlein purpura)
Frequency not reported: Pruritus, phototoxic skin eruptions
Rash was generally mild to moderate and appeared 7 to 14 days after starting therapy.
Common (1% to 10%): Nausea, diarrhea, vomiting
Very rare (less than 0.01%): Constipation, glossitis, stomatitis, pseudomembranous colitis, pancreatitis
Frequency not reported: Epigastric distress, sore mouth, gastrointestinal disturbances, abdominal pain, Clostridioides difficile-associated diarrhea
Common (1% to 10%): Headache
Very rare (less than 0.01%): Dyskinesias, aseptic meningitis, tremor, ataxia, dizziness, lethargy, syncope, paresthesia, convulsions, peripheral neuritis, vertigo, tinnitus
Aseptic meningitis reversed rapidly when this drug was stopped but recurred in a number of cases upon re-exposure to sulfamethoxazole-trimethoprim or this drug alone.
Common (1% to 10%): Monilial overgrowth
Very rare (less than 0.01%): Drug fever
Frequency not reported: Fever
Fatalities have been reported (especially in elder patients or patients with renal or liver dysfunction), but most hematological changes were mild and reversed when therapy was stopped.
Very rare (less than 0.01%): Thrombocytopenia, leukopenia, neutropenia, pancytopenia, bone marrow depression, agranulocytosis, aplastic anemia, hemolytic anemia, eosinophilia, purpura, hemolysis
Frequency not reported: Megaloblastic anemia, methemoglobinemia, depression of hematopoiesis, hematological changes
Fatalities have been reported with cholestatic jaundice and hepatic necrosis.
Very rare (less than 0.01%): Disturbance in liver enzymes, elevated serum transaminases, elevated bilirubin, cholestatic jaundice, hepatic necrosis
Frequency not reported: Elevated ALT, elevated AST
Very rare (less than 0.01%): Hypersensitivity, anaphylaxis, anaphylactoid reaction
Very rare (less than 0.01%): Depression, hallucinations, confusional states, agitation, anxiety, abnormal behavior, insomnia, nightmares
Very rare (less than 0.01%): Cough, shortness of breath, wheeze, epistaxis
Very rare (less than 0.01%): Myalgia, arthralgia, systemic lupus erythematosus
Very rare (less than 0.01%): Impaired renal function (including renal failure)
Frequency not reported: Increased BUN, increased serum creatinine
Whether increased BUN and serum creatinine were due to inhibition of creatinine tubular secretion or genuine renal dysfunction was not established.
Very rare (less than 0.01%): Hematuria
Very rare (less than 0.01%): Periarteritis nodosa
Very rare (less than 0.01%): Uveitis
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