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Commonly reported side effects of trazodone include: blurred vision, dizziness, drowsiness, headache, nausea, vomiting, and xerostomia. Other side effects include: syncope, edema, ataxia, confusion, diarrhea, hypotension, insomnia, sedated state, and tachycardia. See below for a comprehensive list of adverse effects.
Applies to trazodone: oral tablet
Oral route (Tablet, Extended Release; Tablet)
Antidepressants increased the risk compared to placebo of suicidal thinking and behavior in children, adolescents, and young adults with major depressive disorder (MDD) and other psychiatric disorders in short-term studies. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared with placebo in adults beyond age 24, and there was a reduction in risk with antidepressants compared with placebo in adults aged 65 or older. The use of trazodone hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Closely monitor patients of all ages for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Not approved for pediatric use.
Along with its needed effects, trazodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking trazodone:
Some side effects of trazodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to trazodone: compounding powder, oral tablet, oral tablet extended release
The most commonly reported side effects included drowsiness, dry mouth, dizziness, and lightheadedness.
Very common (10% or more): Drowsiness (up to 41%), dizziness (up to 28%), lightheadedness (up to 28%), headache (up to 20%)
Common (1% to 10%): Decreased concentration, head full-heavy, incoordination, syncope, tremor
Frequency not reported: Akathisia, altered taste, convulsion, decreased alertness, dystonia, expressive aphasia, impaired memory, impaired speech, memory disturbance, motor impairment, neuroleptic malignant syndrome, numbness, paresthesia, serotonin syndrome, vertigo
Postmarketing reports: Aphasia, ataxia, cerebrovascular accident, extrapyramidal symptoms, grand mal seizures, stupor, tardive dyskinesia
Drowsiness has occurred during the first few days of treatment, and usually disappeared with continue administration.
Very common (10% or more): Dry mouth (up to 34%), nausea (up to 13%), vomiting (up to 13%)
Common (1% to 10%): Abdominal disorder, constipation, diarrhea, gastric disorder
Frequency not reported: Dyspepsia, flatulence, gastroenteritis, hypersalivation, increased salivation, paralytic ileus, stomach pain
Postmarketing reports: Increased amylase
Very common (10% or more): Hypertension (up to 20%)
Common (1% to 10%): Edema, hypotension
Frequency not reported: Bradycardia, cardiac arrhythmias, chest pain, ECG abnormalities, increased risk of bleeding, orthostatic hypotension, palpitations, premature ventricular beats, QT prolongation, sinus bradycardia, tachycardia, Torsade de pointes, ventricular couplets, ventricular tachycardia
Postmarketing reports: Atrial fibrillation, cardiac arrest, cardiospasm, conduction block, congestive heart failure, myocardial infarction, vasodilation, ventricular ectopic activity
QT prolongation, Torsade de pointes, and ventricular tachycardia have been reported in patients with doses up to 100 mg/day.
Very common (10% or more): Blurred vision (up to 15%)
Common (1% to 10%): Itching eyes, red eyes, tired eyes
Frequency not reported: Angle-closure glaucoma, myoclonus
Postmarketing reports: Diplopia
Very common (10% or more): Nervousness (up to 15%)
Common (1% to 10%): Confusion
Frequency not reported: Activation of mania/hypomania, aggressive reaction, agitation (sometimes exacerbating to delirium), anxiety, cognitive impairment, confusional state, delusions, discontinuation syndrome, hallucinations, hypomania, increased libido, insomnia, libido decreased, mania, nightmares, restlessness, suicidal behavior, suicidal ideation, suicidal thoughts, withdrawal syndrome
Postmarketing reports: Abnormal dreams, paranoid reaction, psychoses
Very common (10% or more): Fatigue (up to 11%)
Common (1% to 10%): Aches, malaise, pain
Frequency not reported: Fever, weakness
Postmarketing reports: Chills, unexplained death
Common (1% to 10%): Weight gain, weight loss
Frequency not reported: Anorexia, hyponatremia, increased appetite
Common (1% to 10%): Nasal congestion, sinus congestion
Frequency not reported: Dyspnea, shortness of breath
Postmarketing reports: Apnea
Common (1% to 10%): Skin condition
Frequency not reported: Hyperhidrosis, pruritus, skin rash
Postmarketing reports: Alopecia, hirsutism, leuconychia, psoriasis, urticaria
Frequency not reported: Delayed urine flow, early menses, hematuria, impotence, increased urinary frequency, micturition disorders, missed periods, priapism, retrograde ejaculation
Postmarketing reports: Breast engorgement, breast enlargement, clitorism, lactation, urinary incontinence, urinary retention
Frequency not reported: Cholestasis intrahepatic, elevated liver enzymes, fulminant hepatitis, hepatic failure with potentially fatal outcome, hepatic function abnormalities, hepatitis, hepatocellular damage, jaundice, severe hepatic disorders
Postmarketing reports: Cholestasis, hyperbilirubinemia, liver enzyme alterations
Frequency not reported: Agranulocytosis, anemia, blood dyscrasias, eosinophilia, leukopenia, thrombocytopenia
Postmarketing reports: Hemolytic anemia, leukocytosis, methemoglobinemia
Frequency not reported: Arthralgia, back pain, limb pain, muscle twitches, myalgia
Frequency not reported: Allergic reactions
Frequency not reported: Influenza-like symptoms
Frequency not reported: Syndrome of inappropriate antidiuretic hormone (SIADH) secretion