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Trandolapril

Generic Name: trandolapril (tran DOE la pril)
Brand Name: Mavik
Physician reviewed trandolapril patient information - includes trandolapril description, dosage and directions.

Average Savings for trandolapril (generic): 49.11%
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Drug Information:
Trandolapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Trandolapril is used to treat high blood pressure (hypertension), and to improve survival after a heart attack. Trandolapril may also be used for purposes not listed in this medication guide. Do not use if you are pregnant, and tell your doctor right away if you become pregnant. If you have diabetes, do not use trandolapril together with any medication that contains aliskiren (a blood pressure medicine). Do not take trandolapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). Learn more

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Trandolapril Side Effects

In Summary

Commonly reported side effects of trandolapril include: cough, dizziness, and hypotension. Other side effects include: cardiogenic shock, syncope, hyperkalemia, increased serum creatinine, and increased blood urea nitrogen. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to trandolapril: oral tablet

Warning

Oral route (Tablet)

Discontinue trandolapril as soon as possible if the patient becomes pregnant, as drugs that target the renin-angiotensin system can cause injury and death to the developing fetus.

Along with its needed effects, trandolapril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trandolapril:

More common

  • Blurred vision
  • confusion
  • difficulty with breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • irregular heartbeat
  • nausea
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • stomach pain
  • sweating
  • unusual tiredness or weakness
  • vomiting
  • weakness or heaviness of the legs

Less common

  • Chest pain or discomfort
  • cool, sweaty skin
  • difficulty with speaking
  • double vision
  • inability to move the arms, legs, or facial muscles
  • muscle cramps in the hands, arms, feet, legs, or face
  • numbness and tingling around the mouth
  • seizures
  • slow heartbeat
  • stomach cramps
  • tremor

Some side effects of trandolapril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Belching
  • cough
  • heartburn
  • indigestion
  • stomach discomfort or upset

Less common

  • Burning feeling in the chest or stomach
  • difficulty with moving
  • joint pain
  • muscle aches, pain, or stiffness
  • swollen joints
  • tenderness in the stomach area

For Healthcare Professionals

Applies to trandolapril: oral tablet

General

The most frequently reported side effects were dizziness and a dry, nonproductive cough.

Respiratory

Very common (10% or more): Cough (up to 35%)

Common (1% to 10%): Bronchitis, upper respiratory tract infections, rhinitis

Uncommon (0.1% to 1%): Dyspnea, sore throat, hoarseness, epistaxis, throat inflammation

Very rare (less than 0.01%): Bronchospasm, sinusitis, lung infiltration, allergic alveolitis, eosinophilic pneumonia

Nervous system

Very common (10% or more): Dizziness (up to 23%)

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Paresthesia, vertigo, taste disturbances, sleep disturbance, insomnia, transient ischemic attacks, drowsiness, cerebral hemorrhage, somnolence

Rare (less than 0.1%): Muscle convulsions, disturbance of balance

Cardiovascular

Very common (10% or more): Hypotension (up to 11%)

Common (1% to 10%): Orthostatic effects, syncope, bradycardia, cardiogenic shock, intermittent claudication, stroke, percutaneous transluminal coronary angioplasty, coronary artery bypass graft surgery

Uncommon (0.1% to 1%): Myocardial infarction, cerebrovascular accident, palpitations, tachycardia, Raynaud's phenomenon, chest pain, arrhythmias, angina pectoris, cerebral hemorrhage, AV first degree block, edema, flushing

Frequency not reported: Vasculitis

Postmarketing reports: Myocardial ischemia, cardiac failure, ventricular tachycardia

Renal

Common (1% to 10%): Renal dysfunction, elevated BUN, increased creatinine

Uncommon (0.1% to 1%): Deterioration of renal function, acute renal failure

Rare (0.01% to 0.1%): Uremia

Very rare (less than 0.01%): Bacterial interstitial nephritis

Dermatologic

Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Pruritus, angioedema, pemphigus, non-specific skin disorder

Rare (0.01% to 0.1%): Hypersensitivity/angioneurotic edema, urticaria, alopecia, psoriasis

Very rare (less than 0.01%): Diaphoresis, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, photosensitivity, blushing, onycholysis

Gastrointestinal

Common (1% to 10%): Diarrhea, vomiting, dyspepsia, gastritis, gastrointestinal pain

Uncommon (0.1% to 1%): Nausea, abdominal pain, indigestion, anorexia, gastrointestinal disorder, constipation, dry mouth, abdominal distention, abdominal cramps

Rare (0.01% to 0.1%): Loss of appetite

Very rare (less than 0.01%): Pancreatitis, intestinal angioedema, stomatitis, glossitis

Metabolic

Very common (10% or more): Increased serum uric acid (15%)

Common (1% to 10%): Hyperkalemia, hypocalcemia

Uncommon (0.1% to 1%): Increased blood urea, gout

Rare (0.01% to 0.1%): Hyponatremia

Very rare (less than 0.01%): Hypoglycemia

Hematologic

Uncommon (0.1% to 1%): Decreased leukocytes, decreased neutrophils

Rare (0.01% to 0.1%): Decreased hemoglobin, decreased hematocrit

Very rare (less than 0.01%): Bone marrow depression, anemia, thrombocytopenia, leukopenia, neutropenia, eosinophilia, agranulocytosis, hemolytic anemia, lymphadenopathy, autoimmune disease

Frequency not reported: Elevated red blood cell sedimentation rate (ESR), leukocytosis

Postmarketing reports: Pancytopenia, decreased platelets

Musculoskeletal

Common (1% to 10%): Myalgia

Uncommon (0.1% to 1%): Muscle cramps, pain in extremities

Frequency not reported: Arthralgia, arthritis

Genitourinary

Common (1% to 10%): Urinary infection

Uncommon (0.1% to 1%): Impotence, decreased libido

Rare (0.01% to 0.1%): Proteinuria

Very rare (less than 0.01%): Oliguria, anuria

Hepatic

Uncommon (0.1% to 1%): Increased liver enzymes

Rare (0.01% to 0.1%): Increased serum bilirubin

Very rare (less than 0.01%): Hepatocellular or cholestatic hepatitis, jaundice

Hypersensitivity

Postmarketing reports: Allergic hypersensitivity reactions (including pruritus and rash)

Other

Common (1% to 10%): Fatigue, influenza-like syndrome, asthenia, malaise

Uncommon (0.1% to 1%): Abnormal feeling

Rare (less than 0.1%): Tinnitus

Postmarketing reports: Fever

Psychiatric

Uncommon (0.1% to 1%): Mood alterations, anxiety, depression

Rare (less than 0.1%): Mental confusion, nervousness

Postmarketing reports: Hallucinations

Endocrine

Rare (less than 0.1%): Gynecomastia

Ocular

Rare (less than 0.1%): Blurred vision

Immunologic

Frequency not reported: Positive antinuclear antibodies (ANA)

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Trandolapril (www.drugs.com/mtm/trandolapril.html).