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Trandolapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme.
Trandolapril is used to treat high blood pressure (hypertension), and to improve survival after a heart attack.
Trandolapril may also be used for purposes not listed in this medication guide.
Do not use if you are pregnant, and tell your doctor right away if you become pregnant.
If you have diabetes, do not use trandolapril together with any medication that contains aliskiren (a blood pressure medicine).
Do not take trandolapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).
You should not use trandolapril if you are allergic to it, or if you:
have a history of angioedema;
recently took a heart medicine called sacubitril; or
are allergic to any other ACE inhibitor, such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, or ramipril.
Do not take trandolapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).
If you have diabetes, do not use trandolapril together with any medication that contains aliskiren (a blood pressure medicine).
You may also need to avoid taking trandolapril with aliskiren if you have kidney disease.
Tell your doctor if you have ever had:
kidney disease (or if you are on dialysis);
liver disease;
heart disease or congestive heart failure;
diabetes; or
if you are on a low-salt diet.
Do not use if you are pregnant, and tell your doctor right away if you become pregnant. Trandolapril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
You should not breastfeed while using trandolapril.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Trandolapril can be taken with or without food.
Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking trandolapril. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure.
Your blood pressure will need to be checked often. Your kidney function and electrolytes may also need to be checked.
If you need surgery, tell the surgeon ahead of time that you are using trandolapril.
If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
Store at room temperature away from moisture and heat.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Do not use potassium supplements or salt substitutes, unless your doctor has told you to.
Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
upper stomach pain, and jaundice (yellowing of the skin or eyes);
chest pain, pounding heartbeats or fluttering in your chest;
high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement;
kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
low white blood cell counts--fever, chills, feeling light-headed, mouth sores, skin sores, sore throat, cough, trouble breathing; or
lung problems--anxiety, sweating, pale skin, severe shortness of breath, wheezing, gasping for breath, cough with foamy mucus.
Common side effects may include:
cough;
dizziness; or
diarrhea.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all your current medicines and any you start or stop using, especially:
a diuretic or "water pill";
gold injections to treat arthritis;
insulin or oral diabetes medicine;
lithium; or
NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may affect trandolapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Trandolapril (www.drugs.com/mtm/trandolapril.html).
Commonly reported side effects of trandolapril include: cough, dizziness, and hypotension. Other side effects include: cardiogenic shock, syncope, hyperkalemia, increased serum creatinine, and increased blood urea nitrogen. See below for a comprehensive list of adverse effects.
Applies to trandolapril: oral tablet
Oral route (Tablet)
Discontinue trandolapril as soon as possible if the patient becomes pregnant, as drugs that target the renin-angiotensin system can cause injury and death to the developing fetus.
Along with its needed effects, trandolapril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking trandolapril:
More common
Less common
Some side effects of trandolapril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Applies to trandolapril: oral tablet
The most frequently reported side effects were dizziness and a dry, nonproductive cough.
Very common (10% or more): Cough (up to 35%)
Common (1% to 10%): Bronchitis, upper respiratory tract infections, rhinitis
Uncommon (0.1% to 1%): Dyspnea, sore throat, hoarseness, epistaxis, throat inflammation
Very rare (less than 0.01%): Bronchospasm, sinusitis, lung infiltration, allergic alveolitis, eosinophilic pneumonia
Very common (10% or more): Dizziness (up to 23%)
Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Paresthesia, vertigo, taste disturbances, sleep disturbance, insomnia, transient ischemic attacks, drowsiness, cerebral hemorrhage, somnolence
Rare (less than 0.1%): Muscle convulsions, disturbance of balance
Very common (10% or more): Hypotension (up to 11%)
Common (1% to 10%): Orthostatic effects, syncope, bradycardia, cardiogenic shock, intermittent claudication, stroke, percutaneous transluminal coronary angioplasty, coronary artery bypass graft surgery
Uncommon (0.1% to 1%): Myocardial infarction, cerebrovascular accident, palpitations, tachycardia, Raynaud's phenomenon, chest pain, arrhythmias, angina pectoris, cerebral hemorrhage, AV first degree block, edema, flushing
Frequency not reported: Vasculitis
Postmarketing reports: Myocardial ischemia, cardiac failure, ventricular tachycardia
Common (1% to 10%): Renal dysfunction, elevated BUN, increased creatinine
Uncommon (0.1% to 1%): Deterioration of renal function, acute renal failure
Rare (0.01% to 0.1%): Uremia
Very rare (less than 0.01%): Bacterial interstitial nephritis
Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Pruritus, angioedema, pemphigus, non-specific skin disorder
Rare (0.01% to 0.1%): Hypersensitivity/angioneurotic edema, urticaria, alopecia, psoriasis
Very rare (less than 0.01%): Diaphoresis, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, photosensitivity, blushing, onycholysis
Common (1% to 10%): Diarrhea, vomiting, dyspepsia, gastritis, gastrointestinal pain
Uncommon (0.1% to 1%): Nausea, abdominal pain, indigestion, anorexia, gastrointestinal disorder, constipation, dry mouth, abdominal distention, abdominal cramps
Rare (0.01% to 0.1%): Loss of appetite
Very rare (less than 0.01%): Pancreatitis, intestinal angioedema, stomatitis, glossitis
Very common (10% or more): Increased serum uric acid (15%)
Common (1% to 10%): Hyperkalemia, hypocalcemia
Uncommon (0.1% to 1%): Increased blood urea, gout
Rare (0.01% to 0.1%): Hyponatremia
Very rare (less than 0.01%): Hypoglycemia
Uncommon (0.1% to 1%): Decreased leukocytes, decreased neutrophils
Rare (0.01% to 0.1%): Decreased hemoglobin, decreased hematocrit
Very rare (less than 0.01%): Bone marrow depression, anemia, thrombocytopenia, leukopenia, neutropenia, eosinophilia, agranulocytosis, hemolytic anemia, lymphadenopathy, autoimmune disease
Frequency not reported: Elevated red blood cell sedimentation rate (ESR), leukocytosis
Postmarketing reports: Pancytopenia, decreased platelets
Common (1% to 10%): Myalgia
Uncommon (0.1% to 1%): Muscle cramps, pain in extremities
Frequency not reported: Arthralgia, arthritis
Common (1% to 10%): Urinary infection
Uncommon (0.1% to 1%): Impotence, decreased libido
Rare (0.01% to 0.1%): Proteinuria
Very rare (less than 0.01%): Oliguria, anuria
Uncommon (0.1% to 1%): Increased liver enzymes
Rare (0.01% to 0.1%): Increased serum bilirubin
Very rare (less than 0.01%): Hepatocellular or cholestatic hepatitis, jaundice
Postmarketing reports: Allergic hypersensitivity reactions (including pruritus and rash)
Common (1% to 10%): Fatigue, influenza-like syndrome, asthenia, malaise
Uncommon (0.1% to 1%): Abnormal feeling
Rare (less than 0.1%): Tinnitus
Postmarketing reports: Fever
Uncommon (0.1% to 1%): Mood alterations, anxiety, depression
Rare (less than 0.1%): Mental confusion, nervousness
Postmarketing reports: Hallucinations
Rare (less than 0.1%): Gynecomastia
Rare (less than 0.1%): Blurred vision
Frequency not reported: Positive antinuclear antibodies (ANA)
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Trandolapril (www.drugs.com/mtm/trandolapril.html).
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