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Tizanidine Hydrochloride

Tizanidine hydrochloride Prescription
Class: Centrally Acting Skeletal Muscle Relaxants
VA Class: MS200
Chemical Name: 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine monohydrochloride
Molecular Formula: C9H8ClN5S•HCl
CAS Number: 64461-82-1
Brands: Zanaflex
Tizanidine Hydrochloride reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI).

Average Savings for tizanidine hydrochloride (generic): 53.62%
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Tizanidine Hydrochloride Drug Information:

Skeletal muscle relaxant; centrally acting α2-adrenergic agonist. Management of spasticity associated with cerebral or spinal injury, alone or in conjunction with other standard therapies (e.g., Baclofen). Individualize dosage according to the patient's requirements and response using the lowest dosage that produces optimum response without adverse effects. Clinically important differences (e.g., increased adverse effects, delayed or more rapid onset of activity) may be apparent when switching administration of capsules or tablets between fed and/or fasting states, switching between capsules and tablets in fed state, or switching between administration of intact capsule and sprinkling capsule contents on applesauce. Be thoroughly faMiliar with possible pharmacokinetic changes associated with these conditions. (See Absorption under Pharmacokinetics.) Learn more

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Tizanidine Hydrochloride Side Effects

In Summary

Commonly reported side effects of tizanidine include: bradycardia, dizziness, drowsiness, hypotension, asthenia, fatigue, and xerostomia. Other side effects include: constipation, and increased liver enzymes. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to tizanidine: oral capsule, oral tablet

Along with its needed effects, tizanidine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tizanidine:

More common

Less common

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking tizanidine:

Symptoms of overdose

Some side effects of tizanidine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to tizanidine: oral capsule, oral tablet

General

The most frequently reported adverse reactions include dry mouth, somnolence/sedation, asthenia, and dizziness.

Nervous system

Very common (10% or more): Somnolence (up to 48%), dizziness (up to 16%)

Common (1% to 10%): Speech disorder, dyskinesia

Frequency not reported: Headache, ataxia, dysarthria

Postmarketing reports: Convulsion, paresthesia, tremor

Gastrointestinal

Very common (10% or more): Dry mouth (up to 49%)

Common (1% to 10%): Vomiting, constipation

Rare (0.01% to 0.1%): Nausea, gastrointestinal disorder

Frequency not reported: Abdominal pain, loss of appetite

Hepatic

Common (1% to 10%): Liver test abnormality

Very rare (less than 0.01%): Hepatic failure

Frequency not reported: Hepatotoxicity

Postmarketing reports: Hepatitis

Cardiovascular

Common (1% to 10%): Bradycardia, hypotension, tachycardia

Postmarketing reports: Syncope, ventricular tachycardia, QT prolongation

Ocular

Common (1% to 10%): Amblyopia

Frequency not reported: Accommodation disorder

Dermatologic

Frequency not reported: Pruritus

Postmarketing reports: Stevens Johnson Syndrome, exfoliative dermatitis, rash

Other

Common (1% to 10%): Fatigue

Frequency not reported: Drug withdrawal reactions including rebound hypertension, tachycardia, and hypertonia

Genitourinary

Common (1% to 10%): Urinary tract infection, urinary frequency

Respiratory

Common (1% to 10%): Pharyngitis, rhinitis

Hypersensitivity

Frequency not reported: Anaphylaxis, hypersensitivity reactions

Postmarketing reports: Anaphylactic Reaction

Immunologic

Common (1% to 10%): Infection, flu syndrome

Musculoskeletal

Rare (0.01% to 0.1%): Muscular weakness

Postmarketing reports: Arthralgia

Psychiatric

Common (1% to 10%): Nervousness

Rare (0.01% to 0.1%): Hallucinations, insomnia, sleep disorders

Frequency not reported: Confusional state

Postmarketing reports: Depression

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Tizanidine Hydrochloride (www.drugs.com/monograph/tizanidine-hydrochloride.html).

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