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Commonly reported side effects of tizanidine include: bradycardia, dizziness, drowsiness, hypotension, asthenia, fatigue, and xerostomia. Other side effects include: constipation, and increased liver enzymes. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to tizanidine: oral capsule, oral tablet
Along with its needed effects, tizanidine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking tizanidine:
More common
Less common
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking tizanidine:
Symptoms of overdose
Some side effects of tizanidine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
For Healthcare Professionals
Applies to tizanidine: oral capsule, oral tablet
GeneralThe most frequently reported adverse reactions include dry mouth, somnolence/sedation, asthenia, and dizziness.
Nervous systemVery common (10% or more): Somnolence (up to 48%), dizziness (up to 16%)
Common (1% to 10%): Speech disorder, dyskinesia
Frequency not reported: Headache, ataxia, dysarthria
Postmarketing reports: Convulsion, paresthesia, tremor
GastrointestinalVery common (10% or more): Dry mouth (up to 49%)
Common (1% to 10%): Vomiting, constipation
Rare (0.01% to 0.1%): Nausea, gastrointestinal disorder
Frequency not reported: Abdominal pain, loss of appetite
HepaticCommon (1% to 10%): Liver test abnormality
Very rare (less than 0.01%): Hepatic failure
Frequency not reported: Hepatotoxicity
Postmarketing reports: Hepatitis
CardiovascularCommon (1% to 10%): Bradycardia, hypotension, tachycardia
Postmarketing reports: Syncope, ventricular tachycardia, QT prolongation
OcularCommon (1% to 10%): Amblyopia
Frequency not reported: Accommodation disorder
DermatologicFrequency not reported: Pruritus
Postmarketing reports: Stevens Johnson Syndrome, exfoliative dermatitis, rash
OtherCommon (1% to 10%): Fatigue
Frequency not reported: Drug withdrawal reactions including rebound hypertension, tachycardia, and hypertonia
GenitourinaryCommon (1% to 10%): Urinary tract infection, urinary frequency
RespiratoryCommon (1% to 10%): Pharyngitis, rhinitis
HypersensitivityFrequency not reported: Anaphylaxis, hypersensitivity reactions
Postmarketing reports: Anaphylactic Reaction
ImmunologicCommon (1% to 10%): Infection, flu syndrome
MusculoskeletalRare (0.01% to 0.1%): Muscular weakness
Postmarketing reports: Arthralgia
PsychiatricCommon (1% to 10%): Nervousness
Rare (0.01% to 0.1%): Hallucinations, insomnia, sleep disorders
Frequency not reported: Confusional state
Postmarketing reports: Depression
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Tizanidine Hcl (www.drugs.com/tizanidine.html).
September 2, 2020
July 17, 2020
August 4, 2022
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July 26, 2022