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Tizanidine is a short-acting muscle relaxer. It works by blocking nerve impulses (pain sensations) that are sent to your brain.
Tizanidine is used to treat spasticity by temporarily relaxing muscle tone.
Tizanidine may also be used for purposes not listed in this medication guide.
Tizanidine is a short-acting medication that should be taken only for daily activities that require relief from muscle spasticity.
You should not take tizanidine if you are also taking fluvoxamine (Luvox) or ciprofloxacin (Cipro).
Do not use tizanidine at a time when you need muscle tone for safe balance and movement during certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone.
Switching between tablets and capsules, or changing the way you take it with regard to eating, can cause an increase in side effects or a decrease in therapeutic effect. Follow your doctor's instructions carefully. After making any changes in how you take tizanidine, contact your doctor if you notice any change in how well the medicine works or if it causes increased side effects.
Do not take more than three doses (36 mg) of tizanidine in a 24-hour period. Too much of this medicine can damage your liver. Cold or allergy medicine, narcotic pain medicine, sleeping pills, other muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by tizanidine.
Avoid drinking alcohol. It can increase some of the side effects of this medicine.
You should not use tizanidine if you are allergic to it, or if:
you also take the antidepressant fluvoxamine (Luvox); or
you also take the antibiotic ciprofloxacin (Cipro).
To make sure this medicine is safe for you, tell your doctor if you have:
liver disease;
kidney disease; or
low blood pressure.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether tizanidine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Take tizanidine exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
In most cases you may take tizanidine up to 3 times in one day if needed. Allow 6 to 8 hours to pass between doses.
You may take tizanidine with or without food, but take it the same way each time. Switching between taking with food and taking it without food can make the medicine less effective or cause increased side effects.
Switching between tablets and capsules can also cause changes in side effects or how well the medicine works.
Taking the tablets with food can increase your blood levels of tizanidine.
Taking the capsules with food can decrease your blood levels of tizanidine.
Follow your doctor's instructions carefully. After making any changes in how you take tizanidine, contact your doctor if you notice any change in side effects or in how well the medicine works.
Tizanidine is a short-acting medication, and its effects will be most noticeable between 1 and 3 hours after you take it. You should take this medicine only for daily activities that require relief from muscle spasms.
Do not take more than three doses (36 mg) in a 24-hour period. Too much of this medicine can damage your liver.
You will need frequent blood tests to check your liver function.
If you stop using this medicine suddenly after long-term use, you may have withdrawal symptoms such as dizziness, fast heartbeats, tremors, and anxiety. Ask your doctor how to safely stop using this medicine.
Store at room temperature away from moisture and heat.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include weakness, drowsiness, confusion, slow heart rate, shallow breathing, feeling light-headed, or fainting.
Do not use tizanidine at a time when you need muscle tone for safe balance and movement during certain activities. In some situations, it may be dangerous for you to have reduced muscle tone.
Drinking alcohol with this medicine can cause side effects.
This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Get emergency medical help if you have signs of an allergic reaction to tizanidine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
weak or shallow breathing;
confusion, hallucinations; or
pain or burning when you urinate.
Common tizanidine side effects may include:
drowsiness, dizziness, weakness;
feeling nervous;
blurred vision;
flu-like symptoms;
dry mouth, trouble speaking;
abnormal liver function tests;
runny nose, sore throat;
urination problems;
vomiting, constipation; or
uncontrolled muscle movements.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Taking tizanidine with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.
Tell your doctor about all your current medicines and any you start or stop using, especially:
acyclovir;
ticlopidine;
zileuton;
birth control pills;
an antibiotic - ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, or ofloxacin;
blood pressure medicine - clonidine, guanfacine, methyldopa;
heart rhythm medicine - amiodarone, mexiletine, propafenone, verapamil; or
stomach acid medicine - cimetidine, famotidine.
This list is not complete. Other drugs may interact with tizanidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Further informationRemember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use tizanidine only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Tizanidine Hcl (www.drugs.com/tizanidine.html).
Commonly reported side effects of tizanidine include: bradycardia, dizziness, drowsiness, hypotension, asthenia, fatigue, and xerostomia. Other side effects include: constipation, and increased liver enzymes. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to tizanidine: oral capsule, oral tablet
Along with its needed effects, tizanidine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking tizanidine:
More common
Less common
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking tizanidine:
Symptoms of overdose
Some side effects of tizanidine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
For Healthcare Professionals
Applies to tizanidine: oral capsule, oral tablet
GeneralThe most frequently reported adverse reactions include dry mouth, somnolence/sedation, asthenia, and dizziness.
Nervous systemVery common (10% or more): Somnolence (up to 48%), dizziness (up to 16%)
Common (1% to 10%): Speech disorder, dyskinesia
Frequency not reported: Headache, ataxia, dysarthria
Postmarketing reports: Convulsion, paresthesia, tremor
GastrointestinalVery common (10% or more): Dry mouth (up to 49%)
Common (1% to 10%): Vomiting, constipation
Rare (0.01% to 0.1%): Nausea, gastrointestinal disorder
Frequency not reported: Abdominal pain, loss of appetite
HepaticCommon (1% to 10%): Liver test abnormality
Very rare (less than 0.01%): Hepatic failure
Frequency not reported: Hepatotoxicity
Postmarketing reports: Hepatitis
CardiovascularCommon (1% to 10%): Bradycardia, hypotension, tachycardia
Postmarketing reports: Syncope, ventricular tachycardia, QT prolongation
OcularCommon (1% to 10%): Amblyopia
Frequency not reported: Accommodation disorder
DermatologicFrequency not reported: Pruritus
Postmarketing reports: Stevens Johnson Syndrome, exfoliative dermatitis, rash
OtherCommon (1% to 10%): Fatigue
Frequency not reported: Drug withdrawal reactions including rebound hypertension, tachycardia, and hypertonia
GenitourinaryCommon (1% to 10%): Urinary tract infection, urinary frequency
RespiratoryCommon (1% to 10%): Pharyngitis, rhinitis
HypersensitivityFrequency not reported: Anaphylaxis, hypersensitivity reactions
Postmarketing reports: Anaphylactic Reaction
ImmunologicCommon (1% to 10%): Infection, flu syndrome
MusculoskeletalRare (0.01% to 0.1%): Muscular weakness
Postmarketing reports: Arthralgia
PsychiatricCommon (1% to 10%): Nervousness
Rare (0.01% to 0.1%): Hallucinations, insomnia, sleep disorders
Frequency not reported: Confusional state
Postmarketing reports: Depression
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Tizanidine Hcl (www.drugs.com/tizanidine.html).
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