Loading

Please wait...

Tisseel

Generic Name: fibrin sealant topical (FYE brin SEE lant TOP i kal)
Brand Name: Artiss, Artiss Duo Set, Artiss Duploject, Tisseel, Tisseel Duploject Kit, Tisseel Valupak Kit
Physician reviewed Tisseel patient information - includes Tisseel description, dosage and directions.
  • Prescription Settings
  • X
  • Local Pharmacy Pickup available at . Pick up your medication at any of our participating pharmacies.
  • Mail Order Home Delivery available at , the easiest way to receive your medications.
  • Learn more

Tisseel Coupons & Prices

Set your location
for drug prices near you

Enter your zip code

Please wait while the prices are loaded...
Click here to try again.

Don’t see your pharmacy listed? Most pharmacies accept our discounts, so have your pharmacist enter this coupon to see if you will save money:

Drug Information:
Fibrin sealant is made of two substances from human plasma that work together to help your blood clot. Tisseel is used to help control bleeding during surgery when other ways to close a wound or incision (such as stitches, bands, or heat) cannot be used. This medicine may also be used to prevent leaks from a wound left in stomach tissue after a colostomy is removed. Tisseel is sometimes used to help skin tissues stick together during skin graft procedures or cosmetic surgery. Tisseel may also be used for purposes not listed in this medication guide. Learn more

Pickup / Home Delivery

USARx offers multiple ways to purchase this medication. Choose the Best option for you!

  • Guaranteed Price
    Local Pharmacy Pickup

    Pay this amount and pick up your prescription at ANY Retail pharmacy of your choice! Walgreens, CVS, Walmart, etc.

  • 30-day supply
    90-day supply
    Mail Order Home Delivery

    The easiest way to receive your medications.

Tisseel Side Effects

Note: This document contains side effect information about fibrin sealant topical. Some of the dosage forms listed on this page may not apply to the brand name Tisseel.

For the Consumer

Applies to fibrin sealant topical: solution

Other dosage forms:

  • topical application sheet

Along with its needed effects, fibrin sealant topical (the active ingredient contained in Tisseel) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking fibrin sealant topical:

Less common

  • Collection of blood or fluids under the skin
  • deep, dark purple bruise
  • itching, pain, redness, or swelling of the skin, wound, or treated area

Incidence not known

  • Blurred vision
  • chest pain, discomfort, or tightness
  • confusion
  • cough
  • difficulty breathing
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, slow, pounding, or irregular heartbeat or pulse
  • flushing, redness of the skin
  • hives, itching, skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lightheadedness, dizziness, or fainting
  • numbness or tingling in the face, arms, or legs
  • pain in the chest, groin, or legs, especially the calves
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • severe, sudden headache
  • shortness of breath
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sweating
  • trouble healing
  • trouble speaking or walking
  • unusual tiredness or weakness
  • unusually warm skin

Some side effects of fibrin sealant topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • nausea

For Healthcare Professionals

Applies to fibrin sealant topical: topical kit, topical solution

General

General side effects have been reported including rare reports of serious adverse events such as paralysis and other compressive complications possibly related to the use of fibrin sealant in combination with resorbable hemostatic agents. There have also been rare reports of fatalities following the misadministration of topical thrombin.

Hypersensitivity

Hypersensitivity side effects such as anaphylactic and anaphylactoid reactions including shock have been reported rarely.

Cardiovascular

Cardiovascular side effects including tachycardia, bradycardia, hypotension, and thromboembolic complications have been reported rarely.

Respiratory

Respiratory side effects including severe dyspnea have been reported rarely.

Dermatologic

Dermatologic side effects including flush, urticaria, and pruritus have been reported rarely.

Gastrointestinal

Gastrointestinal side effects including nausea have been reported rarely.

Other

A D-dimer is a fragment produced during the degradation of a clot. Postoperatively increased D-dimers may result at least partly from the degradation of fibrin sealant.

Other side effects including increased D-dimer levels have been reported in a clinical study on cardiovascular surgery, but did not exceed values reported in the literature occurring after this type of surgery.

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Tisseel (www.drugs.com/mtm/tisseel.html).