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Tinidazole is an antibiotic that fights bacteria in the body.
Tinidazole is used to treat certain infections caused by bacteria, such as infection of the intestines or vagina. It is also used to treat certain sexually transmitted infections.
Tinidazole may also be used for purposes other than those listed in this medication guide.
You should not use this medication if you are allergic to tinidazole or metronidazole (Flagyl), or if you are in the first 3 months of pregnancy.
You should not breast-feed a baby while you are taking tinidazole. However, you may begin nursing again 3 days after you take the last dose. Do not keep any milk you collect with a breast pump while you are taking tinidazole.
Before you take tinidazole, tell your doctor if you have kidney disease (or if you are on dialysis), epilepsy or other seizure disorder, a blood cell disorder such as anemia or low platelets, or a weak immune system.
Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Tinidazole will not treat a viral infection such as the common cold or flu.
Do not drink alcohol while taking tinidazole and for at least 3 days after your treatment ends.
A medicine similar to tinidazole has caused cancer in laboratory animals. It is not known if tinidazole would have the same effect in animals, or in humans. Talk with your doctor about your individual risk.
You should not use this medication if you are allergic to tinidazole or metronidazole (Flagyl), or if you are in the first 3 months of pregnancy.
Tinidazole can pass into breast milk and may harm a nursing baby. Do not breast-feed while you are taking tinidazole and for at least 3 days after your last dose.
You may begin nursing again 3 days after your last dose or tinidazole. If you use a breast pump during treatment, throw out any milk you collect while taking tinidazole. Do not feed it to your baby.
To make sure you can safely take tinidazole, tell your doctor if you have any of these other conditions:
kidney disease (or if you are on dialysis);
epilepsy or other seizure disorder;
a blood cell disorder such as anemia or low platelets; or
a weak immune system.
FDA pregnancy category C. Do not take tinidazole during the first 3 months of pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
A medicine similar to tinidazole has caused cancer in laboratory animals. It is not known if tinidazole would have the same effect in animals, or in humans. Talk with your doctor about your individual risk.
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Take tinidazole with food.
Some infections are treated with only one dose. Follow your doctor's instructions.
Do not share this medication with another person, even if they have the same symptoms you have.
If you are treating a sexually transmitted infection, make sure your sexual partner seeks medical attention to be treated also.
Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Tinidazole will not treat a viral infection such as the common cold or flu.
Store at room temperature away from moisture and heat.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Do not drink alcohol while taking tinidazole and for at least 3 days after your treatment ends. You may have unpleasant side effects such as fast heartbeats, severe nausea, vomiting, sweating, and warmth or tingling under your skin.
Check the label of the products and other medicines you use, such as mouthwash or cough and cold medicines. Alcohol in these products can also cause a reaction if you use them while taking tinidazole.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
fever, chills, body aches, flu symptoms;
numbness, burning pain, or tingly feeling; or
seizure (convulsions).
Less serious side effects may include:
vaginal itching or discharge;
nausea, vomiting, loss of appetite, indigestion;
constipation, diarrhea, stomach cramps;
feeling weak or tired;
headache, dizziness; or
a metallic or bitter taste in your mouth;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all other medicines you use, especially:
any other antibiotic;
a blood thinner such as warfarin (Coumadin);
cyclosporine (Gengraf, Neoral, Sandimmune);
fluorouracil (Adrucil, Efudex, Carac, Flurorplex);
isoniazid (for treating tuberculosis);
lithium (Lithobid, Eskalith);
St. John's wort;
tacrolimus (Prograf);
an antidepressant such as nefazodone;
antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), or voriconazole (Vfend);
a barbiturate such as phenobarbital (Solfoton) and others;
heart or blood pressure medication such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;
HIV medication such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), saquinavir (Invirase), or ritonavir (Norvir); or
seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenobarbital (Solfoton), phenytoin (Dilantin), or primidone (Mysoline).
This list is not complete and other drugs may interact with tinidazole. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Tinidazole (www.drugs.com/mtm/tinidazole.html).
More frequently reported side effects include: nausea, bitter taste, and metallic taste. See below for a comprehensive list of adverse effects.
Applies to tinidazole: oral tablet
Oral route (Tablet)
Carcinogenicity has been seen in mice and rats treated chronically with another agent in the nitroimidazole class (metronidazole). Although such data have not been reported for tinidazole, unnecessary use of tinidazole should be avoided.
Along with its needed effects, tinidazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking tinidazole:
Rare
Incidence unknown
Some side effects of tinidazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Rare
Incidence unknown
Applies to tinidazole: compounding powder, oral tablet
Reported side effects were typically mild, infrequent, and self-limiting. Gastrointestinal side effects were reported most often.
Common (1% to 10%): Nausea, dyspepsia/cramps/epigastric discomfort, vomiting, constipation, diarrhea, abdominal pain, flatulence
Rare (less than 0.1%): Furry tongue
Frequency not reported: Tongue discoloration, stomatitis, dryness of mouth, salivation, oral candidiasis, glossitis
Common (1% to 10%): Metallic/bitter taste, headache, dizziness, vertigo
Rare (less than 0.1%): Coma
Frequency not reported: Convulsions, peripheral neuropathy, ataxia, giddiness, drowsiness, burning sensation, paresthesia, hypoesthesia/numbness, sensory disturbances, dysgeusia
Common (1% to 10%): Weakness/fatigue/malaise
Frequency not reported: Flushing, fever/pyrexia, thirst, Candida overgrowth, fatigue, malaise
In a study involving 450 patients with fixed drug eruptions, 8 patients were found to have this oral drug as the probable causative agent. The fixed drug eruptions varied as to duration, shape and size, symptoms, number of lesions, and body site(s) affected. The study did not break these factors down for each individual causative agent.
Common (1% to 10%): Allergic dermatitis, pruritus
Frequency not reported: Urticaria, rash, sweating, angioedema, fixed drug eruption
Common (1% to 10%): Anorexia, decreased appetite
Common (1% to 10%): Urinary tract infection, dysuria/painful urination, urine abnormality, pelvic pain, vulvovaginal discomfort, vaginal odor, menorrhagia
Frequency not reported: Darkened urine/chromaturia, increased vaginal discharge, female genital pruritus, Candida vaginitis
Common (1% to 10%): Upper respiratory tract infection
Rare (less than 0.1%): Bronchospasm, dyspnea, pharyngitis
Rare (less than 0.1%): Confusion, depression
Frequency not reported: Insomnia
Rare (less than 0.1%): Reversible thrombocytopenia
Frequency not reported: Neutropenia, leukopenia, increased eosinophil count, decreased hemoglobin
Severe acute hypersensitivity reactions have been reported during initial or subsequent exposure to this drug.
Frequency not reported: Drug hypersensitivity
Postmarketing reports: Severe acute hypersensitivity reactions, hypersensitivity reactions (included urticaria, pruritus, rash, flushing, sweating, dryness of mouth, fever, burning sensation, thirst, salivation, angioedema, Stevens-Johnson syndrome, erythema multiforme)
Frequency not reported: Hepatic abnormalities (included raised transaminase level), increased AST, increased blood bilirubin
Frequency not reported: Increased blood urea
Frequency not reported: Palpitations
Frequency not reported: Arthralgias, myalgias, arthritis
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Tinidazole (www.drugs.com/mtm/tinidazole.html).
June 26, 2020
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