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Tiazac (diltiazem) belongs to a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels.
Tiazac is used to treat hypertension (high blood pressure)
Tiazac is also used for the treatment of chronic stable angina. (chest pain).
You should not use Tiazac if you have very low blood pressure, a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), or if you have recently had a heart attack and you have a build-up of fluid in your lungs.
Before taking Tiazac, tell your doctor if you have kidney disease, liver disease, or congestive heart failure.
Tiazac may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Do not stop taking this medication without first talking to your doctor. If you stop taking this medicine suddenly, your condition may become worse.
Tiazac may be only part of a complete program of treatment that also includes diet, exercise, and other medications. Follow your diet, medication, and exercise routines very closely.
If you are being treated for high blood pressure, keep using Tiazac even if you feel well. High blood pressure often has no symptoms.
You should not use Tiazac if you are allergic to diltiazem, or if you have:
a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker);
very low blood pressure;
if you have recently had a heart attack and you have a build-up of fluid in your lungs.
To make sure Tiazac is safe for you, tell your doctor if you have ever had:
congestive heart failure;
low blood pressure;
liver disease; or
kidney disease.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
You should not breast-feed while using this medicine.
Take Tiazac extended-release capsules exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
Swallow the capsule whole and do not crush, chew, or open the capsule.
Your blood pressure will need to be checked often and you may need frequent blood tests.
You may be given other heart or blood pressure medications to use, including nitroglycerin or a beta-blocker medicine (such as atenolol, carvedilol, metoprolol, propranolol, or sotalol). Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice.
Keep using your medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
If you need surgery, tell your surgeon you currently use blood pressure medication.
You should not stop taking Tiazac suddenly. Stopping suddenly may make your condition worse.
Store at room temperature away from moisture, heat, and light.
Usual Adult Dose for Hypertension:
Extended Release Capsules:
-Initial dose: 120 to 240 mg orally once a day, increasing the dose as needed
-Maintenance dose: 120 to 540 mg orally once a day
-Maximum dose: 540 mg/day
Comments:
-Once a day formulations should be taken at the same time of day, either in the morning or evening.
Usual Adult Dose for Angina Pectoris Prophylaxis:
Extended Release Capsules:
-Initial dose: 120 to 180 mg orally once a day, increasing the dose every 7 to 14 days as needed
-Maximum dose: 540 mg/day
Use:
-Treatment of chronic stable angina
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include slow heartbeats or fainting.
Avoid drinking alcohol while taking Tiazac.
Avoid taking an herbal supplement containing St. John's wort.
Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.
Get emergency medical help if you have signs of an allergic reaction to Tiazac (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Call your doctor at once if you have:
chest pain;
slow heartbeats;
pounding heartbeats or fluttering in your chest;
a light-headed feeling, like you might pass out; or
heart problems - swelling, rapid weight gain, feeling short of breath.
Common Tiazac side effects may include:
swelling;
dizziness, weakness;
headache;
nausea; or
rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many drugs can interact with diltiazem. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Tiazac only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Tiazac (www.drugs.com/tiazac.html).
Note: This document contains side effect information about diltiazem. Some of the dosage forms listed on this page may not apply to the brand name Tiazac.
More frequent side effects include: dizziness, edema, asthenia, headache, and vasodilation. See below for a comprehensive list of adverse effects.
Applies to diltiazem: oral capsule extended release, oral capsule extended release 12 hr, oral capsule extended release 24 hr, oral tablet, oral tablet extended release, oral tablet extended release 24 hr
Other dosage forms:
Along with its needed effects, diltiazem (the active ingredient contained in Tiazac) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking diltiazem:
More common
Less common
Incidence not known
Some side effects of diltiazem may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Incidence not known
Applies to diltiazem: compounding powder, intravenous powder for injection, intravenous solution, oral capsule extended release, oral tablet, oral tablet extended release
The most commonly reported side effects include edema, headache, and dizziness.
Very common (10% or more): Peripheral edema (up to 15%)
Common (1% to 10%): Arrhythmia (junctional rhythm/isorhythmic dissociation), asymptomatic/symptomatic hypotension, atrioventricular (AV) block (first/second/third degree), bradycardia, bundle branch block, ECG abnormality, edema, extrasystole/ventricular extrasystole, flushing, lower limb edema, palpitations, vasodilation
Uncommon (0.1% to 1%): Orthostatic hypotension
Frequency not reported: Angina, asystole/cardiac arrest, atrial flutter, chest pain, development/aggravation of congestive heart failure, hypotension, sinoatrial block, sinus node dysfunction, sinus pause/arrest, vasculitis, ventricular arrhythmia, ventricular fibrillation, ventricular tachycardia/tachycardia
Postmarketing reports: Myocardial infarction, vasodilation symptoms (flushing, lower limb edema, sweating)
A patient with Prinzmetal's angina developed asystole after a single, 60 mg dose.
Myocardial infarction was not readily distinguishable from the natural history of the disease.
Vasodilatory events (e.g., peripheral edema, headache, flushing) are dose-related and may be more common in elderly patients.
First degree AV block and sinus bradycardia occurred more frequently with higher doses.
Common (1% to 10%): Asthenia, fatigue, flu syndrome, infection, malaise, pain
Frequency not reported: Thirst, tinnitus
Common (1% to 10%): Abdominal enlargement, constipation, dyspepsia, gastric pain, nausea
Uncommon (0.1% to 1%): Diarrhea, vomiting
Rare (0.01% to 0.1%): Dry mouth
Frequency not reported: Gastrointestinal disorder, gingivitis, gingival hyperplasia
Well-documented cases of rashes (as leukocytoclastic vasculitis) have been reported, but a definitive between these events and this drug have not been established.
Lichenoid keratosis and hyperpigmentation occurred in skin exposed to the sun.
Common (1% to 10%): Erythema, hot flushes, rash, urticaria
Frequency not reported: Acute generalized exanthematous pustular dermatitis, desquamative erythema with/without fever exfoliative dermatitis, facial edema, hyperhidrosis/sweating, hyperpigmentation, leukocytoclastic vasculitis, petechiae, photosensitivity (lichenoid keratosis), pruritus, Steven-Johnson's syndrome
Postmarketing reports: Allergic dermatitis, alopecia, angioneurotic edema, erythema multiforme, generalized dermatitis, musculocutaneous reactions, simple erythema, toxic epidermal necrolysis
Common (1% to 10%): Bronchitis, cough, increased cough, pharyngitis, sinus/nasal congestion
Frequency not reported: Dyspnea, epistaxis
Postmarketing reports: Asthma aggravation, bronchospasm
Common (1% to 10%): Dizziness, headache, lightheadedness
Frequency not reported: Amnesia, dysgeusia, extrapyramidal syndrome/symptoms, gait abnormality, paresthesia, somnolence, syncope, tremor
Dizziness occurred more frequently with higher doses.
Common (1% to 10%): Myalgia
Frequency not reported: Creatine phosphokinase (CPK) increase, muscle cramp, muscle pain, muscle weakness, myopathy, neck rigidity, osteoarticular pain
Common (1% to 10%): Gout
Frequency not reported: Anorexia, hyperglycemia, hyperuricemia, mild elevation of alkaline phosphatase, mild elevation of lactate dehydrogenase, thirst, weight increase
Common (1% to 10%): Impotence
Frequency not reported: Albuminuria, crystalluria, nocturia, polyuria, sexual difficulties
Common (1% to 10%): Conjunctivitis
Frequency not reported: Amblyopia, eye irritation, periorbital edema, retinopathy
Common (1% to 10%): Injection site reactions (e.g., itching, burning)
Uncommon (0.1% to 1%): Insomnia, nervousness
Frequency not reported: Abnormal dreams, depression, hallucinations, mood changes (including depression), personality change
There were rare cases of clinical hepatitis that were reversible with discontinuation of this drug.
Uncommon (0.1% to 1%): Increased hepatic enzymes (ALT, AST)
Frequency not reported: Clinical hepatitis/hepatitis
Frequency not reported: Eosinophilia, hemolytic anemia, increased bleeding time, leukopenia, lymphadenopathy, thrombocytopenia
Postmarketing reports: Purpura
Frequency not reported: Allergic reactions, angioedema (including facial/periorbital edema)
Frequency not reported: Gynecomastia
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Tiazac (www.drugs.com/tiazac.html).
March 28, 2020
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