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Thymoglobulin

Generic Name: anti-thymocyte globulin (rabbit) (AN tee THYE moe syt GLOB ue lin)
Brand Name: Thymoglobulin
Physician reviewed Thymoglobulin (rabbit) (rabbit) patient information - includes Thymoglobulin (rabbit) description, dosage and directions.
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Drug Information:
Thymoglobulin is a sterilized solution made of the cells of rabbits that have been injected with white blood cells from humans. Thymoglobulin lowers your body's immune system. The immune system helps your body fight infections. The immune system can also fight or "reject" a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader. Thymoglobulin is used together with other medicines to prevent your body from rejecting a kidney transplant. Thymoglobulin may also be used for purposes not listed in this medication guide. Learn more

Thymoglobulin Side Effects

Thymoglobulin Side Effects

Note: This document contains side effect information about anti-thymocyte globulin (rabbit). Some of the dosage forms listed on this page may not apply to the brand name Thymoglobulin.

For the Consumer

Applies to anti-thymocyte globulin (rabbit): intravenous powder for solution

Warning

Intravenous route (Powder for Solution)

Antithymocyte globulin rabbit should only be used by physicians experienced in immunosuppressive therapy in transplantation.

Along with its needed effects, anti-thymocyte globulin (rabbit) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking anti-thymocyte globulin (rabbit):

More common

  • Black, tarry stools
  • bladder pain
  • bleeding gums
  • blurred vision
  • chest pain
  • chills
  • cloudy or bloody urine
  • cold
  • confusion
  • cough or hoarseness
  • diarrhea
  • dizziness
  • fast heartbeat
  • fever
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • headache
  • irregular or slow heartbeat
  • joint pain
  • loss of appetite
  • lower back or side pain
  • muscle aches and pains
  • nausea
  • nervousness
  • numbness or tingling around the lips, hands, or feet
  • painful or difficult urination
  • pounding in the ears
  • runny nose
  • shivering
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • troubled breathing
  • unexplained anxiety
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • weakness or heaviness of the legs

Less common

  • Burning feeling in chest or stomach tenderness
  • burning or stinging of the skin
  • indigestion
  • inflammation of joints
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
  • stomach upset

Rare

  • Difficulty swallowing
  • hives, itching, rash
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

Some side effects of anti-thymocyte globulin (rabbit) may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain
  • anxiety
  • loss of strength or energy
  • nausea
  • pain
  • swelling of the ankles, feet, and fingers
  • tightness in the chest

For Healthcare Professionals

Applies to anti-thymocyte globulin (rabbit): intravenous powder for injection

Cardiovascular

Very common (10% or more): Hypertension (18%)

Common (1% to 10%): Tachycardia

Frequency not reported: Myocardial infarction, hypotension, reduced oxygen supply to tissues, chest pain

Other

Very common (10% or more): Pyrexia (28%), pain (26%)

Frequency not reported: Lethargy, malaise

Nervous system

Very common (10% or more): Headache (18%)

Frequency not reported: Dizziness, decreased sensitivity

Hematologic

Very common (10% or more): Leukopenia (63%), anemia (25%), thrombocytopenia (16%), neutropenia

Common (1% to 10%): Febrile neutropenia

Gastrointestinal

Very common (10% or more): Constipation (33%), vomiting (12%)

Common (1% to 10%): Abdominal pain, diarrhea, moniliasis, gastritis, dysphagia

Frequency not reported: Abdominal tenderness, abdominal discomfort, pain in the mouth and throat

Genitourinary

Very common (10% or more): Urinary tract infection (42%)

Dermatologic

Very common (10% or more): Rash (13%), sweating (13%), acne (12%)

Common (1% to 10%): Herpes simplex

Frequency not reported: Pruritus

Respiratory

Very common (10% or more): Dyspnea (28%), lower respiratory tract infection (13%), upper respiratory tract infection (11%)

Common (1% to 10%): Nasopharyngitis

Frequency not reported: Cough, throat irritation, shortness of breath, pulmonary edema

Metabolic

Common (1% to 10%): Hyperphosphatemia, acidosis, hypokalemia, anorexia

Hypersensitivity

Uncommon (0.1% to 1%): Cytokine release syndrome (CRS), anaphylaxis

Immunologic

Very common (10% or more): Infection (31%), cytomegaloviral infection (13%), sepsis (12%)

Common (1% to 10%): Herpes zoster, oral candidiasis, sepsis

Uncommon (0.1% to 1%): Serum sickness

Local

Uncommon (0.1% to 1%): Infusion related reactions

Frequency not reported: Localized edema

Musculoskeletal

Very common (10% or more): Myalgia (20%), arthralgia (15%)

Frequency not reported: Joint pain

Psychiatric

Very common (10% or more): Insomnia (20%), anxiety (14%)

Frequency not reported: Confusional state, agitation, restlessness

Hepatic

Common (1% to 10%): Transaminases increased

Uncommon (0.1% to 1%): Hepatocellular injury, hepatotoxicity, hepatic failure

Oncologic

Common (1% to 10%): Malignancy, lymphomas (which may be virally mediated), neoplasms malignant (solid tumors)

Uncommon (0.1% to 1%): Lymphoproliferative disorder

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Thymoglobulin (www.drugs.com/mtm/thymoglobulin-rabbit.html).