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Teniposide

Generic Name: teniposide (ten IP oh side)
Brand Name: Vumon
Physician reviewed teniposide patient information - includes teniposide description, dosage and directions.
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Drug Information:
Teniposide is a cancer medication that interferes with the growth and spread of cancer cells in the body. Teniposide is used to treat acute lymphoblastic leukemia (a type of blood cancer) in children. Teniposide is usually given after other cancer medications have been tried without successful treatment. Teniposide may also be used for purposes not listed in this medication guide. Do not receive teniposide if you are pregnant. It could harm the unborn baby. Use birth control to prevent pregnancy while you are receiving teniposide, whether you are a man or a woman. Teniposide use by either parent may cause birth defects. Learn more

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Teniposide Side Effects

In Summary

Commonly reported side effects of teniposide include: infection and bone marrow depression. Other side effects include: bronchospasm, hypersensitivity reaction, hypotension, hemorrhage, dyspnea, fever, hypertension, tachycardia, and chills. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to teniposide: intravenous solution

Warning

Intravenous route (Solution)

Teniposide should be administered under the supervision of a qualified physician experienced in prescribing chemotherapy. Severe myelosuppression, resulting in infection or bleeding, may occur with teniposide. Hypersensitivity reactions, including anaphylaxis-like symptoms, may occur with initial dosing or with repeated exposure to teniposide. Epinephrine, with or without corticosteroids and antihistamines, has been used to treat hypersensitivity reactions.

Along with its needed effects, teniposide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking teniposide:

More common

  • Black, tarry stools
  • blood in urine or stools
  • chills
  • cough or hoarseness
  • fever
  • hives
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on skin
  • shortness of breath
  • tightness in chest or wheezing
  • troubled breathing
  • unusual bleeding or bruising

Check with your doctor as soon as possible if any of the following side effects occur while taking teniposide:

More common

  • Flushing of face
  • sores in mouth or on lips
  • unusually fast heartbeat
  • unusual tiredness

Less common

  • Skin rash

Rare

  • Decreased urination
  • swelling of face, fingers, feet, or lower legs
  • yellow eyes or skin

Some side effects of teniposide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • nausea and vomiting

This medicine often causes a temporary loss of hair. After treatment with teniposide has ended, normal hair growth should return.

For Healthcare Professionals

Applies to teniposide: intravenous solution

Hematologic

Very common (10% or more): Neutropenia (less than 2000 ANC/mcL) (95%), leukopenia (less than 3000 WBC/mcL) (89%), anemia (88%), thrombocytopenia (less than 100,000 plt/mcL) (85%), myelosuppression (75%)

Common (1% to 10%): Bleeding

Hypersensitivity

Common (1% to 10%): Hypersensitivity reaction (e.g., chills, fever, tachycardia, flushing, bronchospasm, dyspnea, rash, hypertension, hypotension)

Cardiovascular

Common (1% to 10%): Hypotension

Immunologic

Very common (10% or more): Infection (12%)

Dermatologic

Very common (10% or more): Mucositis (76%), diarrhea (33%), nausea/vomiting (29%)

Common (1% to 10%): Alopecia, rash

Nervous system

Uncommon (0.1% to 1%): Neurotoxicity

Frequency not reported: Headache, asthenia

Other

Common (1% to 10%): Fever

Psychiatric

Frequency not reported: Confusion

Hepatic

Uncommon (0.1% to 1%): Hepatic dysfunction

Renal

Uncommon (0.1% to 1%): Renal dysfunction

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Teniposide (www.drugs.com/mtm/teniposide.html).