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Temozolomide

Temozolomide Prescription
Generic Name: temozolomide (TEM oh ZOE loe mide)
Brand Name: Temodar
Physician reviewed temozolomide patient information - includes temozolomide description, dosage and directions.
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Temozolomide Drug Information:

Temozolomide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Temozolomide is used together with radiation therapy to treat certain types of brain tumor in adults. Temozolomide is usually given after other cancer medicines have been tried without success. Temozolomide may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare prOviders about all your medical conditions, allergies, and all medicines you use. Learn more

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Temozolomide Side Effects

In Summary

Commonly reported side effects of temozolomide include: leukopenia. Other side effects include: decreased hemoglobin. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to temozolomide: oral capsule

Other dosage forms:

  • intravenous powder for solution

Along with its needed effects, temozolomide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking temozolomide:

Less common or rare

  • Amnesia
  • black, tarry stools
  • blood in the urine or stools
  • convulsions
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • muscle weakness or paralysis on one or both sides of the body
  • painful or difficult urination
  • pinpoint red spots on the skin
  • swelling of the feet or lower legs
  • unusual bleeding or bruising

Incidence not known

  • Abdominal or stomach pain or tenderness
  • blistering, peeling, or loosening of the skin
  • chest pain
  • clay colored stools
  • cough
  • decreased appetite
  • diarrhea
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • headache
  • hives, itching, or skin rash
  • joint or muscle pain
  • nausea or vomiting
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sneezing
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • tightness in the chest
  • troubled breathing
  • unusual tiredness or weakness
  • yellow skin or eyes

Some side effects of temozolomide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Constipation

Less common or rare

  • Anxiety
  • blurred or double vision
  • breast pain (in females)
  • burning or prickling feeling on the skin
  • confusion
  • diarrhea
  • difficulty with speaking
  • drowsiness
  • increased urge to urinate
  • loss of appetite
  • loss of muscle coordination
  • mental depression
  • runny or stuffy nose
  • trouble sleeping
  • unusual weight gain

For Healthcare Professionals

Applies to temozolomide: intravenous powder for injection, oral capsule

Gastrointestinal

Very common (10% or more): Constipation (Up to 33%), nausea (Up to 53%), vomiting (Up to 42%), diarrhea (16%)

Common (1% to 10%): Abdominal pain, diarrhea, stomatitis, taste perversion, dysphagia, dyspepsia

Uncommon (0.1% to 1%): Abdominal distension, fecal incontinence, gastrointestinal disorder, gastroenteritis, hemorrhoids

General

The most common side effects were alopecia, nausea, vomiting, anorexia, headache, and constipation.

Nervous system

Very common (10% or more): Headache (Up to 41%), convulsions (Up to 23%), hemiparesis (18%), abnormal coordination (11%)

Common (1% to 10%): Dizziness, confusion, memory impairment, amnesia, paresthesia, somnolence, paresis, urinary incontinence, ataxia, abnormal gait, neuropathy, balance impairment, speech disorder, tremors, hemiparesis

Cardiovascular

Very common (10% or more): Peripheral edema (11%)

Uncommon (0.1% to 1%): Palpitation

Other

Very common (10% or more): Fatigue (Up to 61%), asthenia (13%), fever (13%)

Common (1% to 10%): Weakness, radiation injury, face edema, pain, hearing impairment

Uncommon (0.1% to 1%): Otitis media, tinnitus, hyperacusis, earache, deafness, vertigo, impotence, vaginal hemorrhage, menorrhagia, amenorrhea, vaginitis, breast pain

Endocrine

Common (1% to 10%): Adrenal hypercorticism

Respiratory

Common (1% to 10%): Cough, dyspnea, upper respiratory tract infection, pharyngitis, sinusitis

Post-marketing surveillance: Interstitial pneumonitis, pneumonitis, alveolitis, pulmonary fibrosis

Dermatologic

A case of diffuse erythematous skin rash that progressed to an extensive full body desquamative skin rash has been reported. Even though temozolomide was permanently discontinued, the patient continued to experience the rash on a long-term basis with periodic exacerbations.

Very common (10% or more): Alopecia (55 to 69%), rash (13 to 19%)

Common (1% to 10%): Dry skin, erythema, pruritus, petechiae

Uncommon (0.1% to 1%): Photosensitivity reaction, abnormal pigmentation, sweating increased

Post-marketing surveillance: Toxic epidermal necrolysis, Stevens-Johnson syndrome

Psychiatric

Common (1% to 10%): Insomnia, anxiety, depression

Uncommon (0.1% to 1%): Agitation, apathy, behavior disorder, hallucination, amnesia

Metabolic

Very common (10% or more): Anorexia (19 to 27%)

Common (1% to 10%): Weight increase, weight decrease, hyperglycemia

Uncommon (0.1% to 1%): Hypokalemia

Musculoskeletal

Common (1% to 10%): Arthralgia, back pain

Ocular

Common (1% to 10%): Vision blurred, diplopia

Uncommon (0.1% to 1%): Hemianopia, visual acuity reduced, vision disorder, visual field defect, eye pain, dry eyes

Immunologic

Common (1% to 10%): Infection, Herpes simplex, wound infection, candidiasis oral

Uncommon (0.1% to 1%): Herpes zoster, influenza-like symptoms

Post-marketing surveillance: Opportunistic infections including Pneumocystis pneumonia

Oncologic

Post-marketing surveillance: Secondary malignancies including myeloid leukemia

Hematologic

Common (1% to 10%): Thrombocytopenia, hemorrhage, leukopenia, neutropenia, lymphopenia, febrile neutropenia, anemia

Post-marketing surveillance: Prolonged pancytopenia, myelodysplastic syndrome

Hepatic

Common (1% to 10%): ALT increased

Uncommon (0.1% to 1%): Hepatic enzymes increased, Gamma GT increased, AST increased

Post-marketing surveillance: Fatal and severe hepatotoxicity, elevation of liver enzymes, hyperbilirubinemia, cholestasis, hepatitis

Hypersensitivity

Common (1% to 10%): Allergic reaction

Renal

Common (1% to 10%): Urinary tract infection, micturition increased frequency

Uncommon (0.1% to 1%): Dysuria

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Temozolomide (www.drugs.com/mtm/temozolomide.html).