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Generic Name: Diphtheria and Tetanus Toxoids (dif THEER ee a & TET a nus TOKS oyds)
Brand Name: TDVAX, Tenivac
Easy-to-read patient leaflet for TDVAX. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
This medicine may interact with other drugs or health problems. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take TDVAX (diphtheria and tetanus toxoids) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. For all patients taking TDVAX (diphtheria and tetanus toxoids): Children: Learn more

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Tdvax Side Effects

For the Consumer

Applies to diphtheria toxoid/tetanus toxoid: intramuscular suspension

Along with its needed effects, diphtheria toxoid/tetanus toxoid may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking diphtheria toxoid / tetanus toxoid:

Less common

  • Fever
  • general feeling of discomfort or illness
  • unusual tiredness or weakness

Incidence not known

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chills
  • convulsions
  • cough
  • difficulty with swallowing
  • dizziness
  • fainting
  • fast heartbeat
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • shortness of breath
  • skin rash
  • swelling or puffiness of the face
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • tightness in the chest
  • tingling of the hands or feet
  • unusual weight gain or loss
  • wheezing

Some side effects of diphtheria toxoid / tetanus toxoid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Hard lumps, redness, tenderness, or warmth at the injection site

Less common

  • Headache

Incidence not known

  • Difficulty with moving
  • joint pain
  • lack or loss of strength
  • muscle aching or cramping
  • muscle stiffness
  • nausea
  • pain in the arms or legs
  • swollen joints
  • vomiting

For Healthcare Professionals

Applies to diphtheria toxoid / tetanus toxoid: intramuscular suspension


The most common adverse events were slight pain at the injection site, crying, fever, and loss of appetite.


Very common (10% or more): Crying (15.2%)

Common (1% to 10%): Fever 38C or higher


Very common (10% or more): Slight pain at the injection site (11%)

Uncommon (0.1% to 1%): Redness/swelling 2.5 cm or larger at the injection site, moderate pain at the injection site, hardness 2.5 cm or larger at the injection site

Postmarketing reports: Injection site inflammation, injection site hypersensitivity


Common (1% to 10%): Loss of appetite

Nervous system

Frequency not reported: Dizziness

Postmarketing reports: Convulsion, somnolence, syncope, headache


Postmarketing reports: Lymphadenopathy


Postmarketing reports: Pallor


Postmarketing reports: Rash, urticaria


Postmarketing reports: Nausea

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Tdvax (www.drugs.com/cdi/tdvax.html).