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Synthroid

Generic Name: levothyroxine (LEE voe thye ROX een)
Brand Names: Levoxyl, Synthroid, Tirosint, Unithroid
Synthroid (levothyroxine) treats hypothyroidism (low thyroid hormone) and different types of goiters (enlarged thyroid gland). Includes Synthroid side effects, interactions and indications.

Average Savings for unithroid (generic): 74.63%
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Drug Information:
Synthroid (levothyroxine) is a Thyroid medicine that replaces a hormone normally produced by your Thyroid gland to regulate the body's energy and metabolism. Levothyroxine is given when your Thyroid does not produce enough of this hormone on its own. Synthroid is used to treat hypoThyroidism (low Thyroid hormone). Synthroid is also used to treat or prevent goiter (enlarged Thyroid gland), which can be caused by hormone imbalances, radiation treatment, surgery, or cancer. You may not be able to take Synthroid if you have certain medical conditions. Tell your doctor if you have an untreated or uncontrolled adrenal gland disorder, a Thyroid disorder called thyrotoxicosis, or if you have any recent or current symptoms of a heart attack. Learn more

Pickup / Home Delivery

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Synthroid Medicare Coverage

Overview

Does Medicare cover Synthroid?

Yes

100% of Medicare Part D and Medicare Advantage plans cover this drug.
How much is my Synthroid co-pay with Medicare?

It depends. Which coverage stage are you in? Click on a tab below…

CO-PAY RANGE

FREE – $14

In the Deductible co-pay stage, you are responsible for the full cost of your prescriptions. Your Medicare deductible cannot exceed $360 in 2016.

Ways to Save on Synthroid

Here are some ways that may lower the cost of your synthroid prescription.

  • Instead of Medicare, Use a USA Rx Coupon

    If your Medicare co-pay is higher, you can save money by using a USARx coupon instead.

Synthroid Side Effects

Note: This document contains side effect information about levothyroxine. Some of the dosage forms listed on this page may not apply to the brand name Synthroid.

For the Consumer

Applies to levothyroxine: oral capsule liquid filled, oral tablet

Other dosage forms:

  • injection powder for solution

Warning

Oral route (Capsule; Tablet; Solution)

Thyroid hormones, including levothyroxine, should not be used either alone or with other therapeutic agents for the treatment of obesity or weight loss. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.

Along with its needed effects, levothyroxine (the active ingredient contained in Synthroid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking levothyroxine:

Less common

  • Chest pain or discomfort
  • decreased urine output
  • difficult or labored breathing
  • difficulty with swallowing
  • dilated neck veins
  • extreme fatigue
  • fainting
  • fast, slow, irregular, pounding, or racing heartbeat or pulse
  • fever
  • heat intolerance
  • hives or welts, skin itching, rash, or redness
  • irregular breathing
  • irritability
  • menstrual changes
  • nausea
  • pain or discomfort in the arms, jaw, back, or neck
  • sweating
  • swelling of the eyes, face, lips, throat, or tongue
  • tightness in the chest
  • tremors

Rare

  • Blurred or double vision
  • dizziness
  • eye pain
  • lack or slowing of normal growth in children
  • limp or walk favoring one leg
  • pain in the hip or knee
  • seizures
  • severe headache

Get emergency help immediately if any of the following symptoms of overdose occur while taking levothyroxine:

Symptoms of overdose

  • Change in consciousness
  • cold, clammy skin
  • confusion
  • disorientation
  • fast or weak pulse
  • lightheadedness
  • loss of consciousness
  • sudden headache
  • sudden loss of coordination
  • sudden slurring of speech

Some side effects of levothyroxine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Abdominal or stomach cramps
  • change in appetite
  • crying
  • diarrhea
  • false or unusual sense of well-being
  • fear or nervousness
  • feeling not well or unhappy
  • feeling of discomfort
  • feeling of warmth
  • feeling things are not real
  • feelings of suspicion and distrust
  • hair loss
  • headache
  • increased appetite
  • mental depression
  • muscle weakness
  • quick to react or overreact emotionally
  • rapidly changing moods
  • redness of the face, neck, arms, and occasionally, upper chest
  • restlessness
  • trouble getting pregnant
  • trouble sitting still
  • unusual tiredness or weakness
  • vomiting
  • weight gain or loss

For Healthcare Professionals

Applies to levothyroxine: compounding powder, injectable powder for injection, intravenous powder for injection, intravenous solution, oral capsule, oral solution, oral tablet

General

The more commonly reported adverse events have included those of hyperthyroidism due to therapeutic overdose including arrhythmias, myocardial infarction, dyspnea, muscle spasm, headache, nervousness, irritability, insomnia, tremors, muscle weakness, increased appetite, weight loss, diarrhea, heat intolerance, menstrual irregularities, and skin rash.

Cardiovascular

Cardiac function was evaluated in 20 patients requiring TSH suppression for either thyroid goiter or following thyroidectomy and radioactive iodine therapy for thyroid cancer and in 20 age and sex-matched controls. TSH suppression was associated with an increased incidence of premature ventricular beats, an increased left ventricular mass index, and enhanced left ventricular systolic function. The clinical significance of these changes remains to be determined.

Overtreatment with this drug may cause an increase in heart rate, cardiac wall thickness, and cardiac contractility and may precipitate angina or arrhythmias, particularly in patients with cardiovascular disease and in elderly patients.

Frequency not reported: Palpitations, tachycardia, hypertension, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest

Endocrine

Frequency not reported: Changes in symptom presentation for diabetes and adrenal cortical insufficiency

Nervous system

Frequency not reported: Headache, hyperactivity, insomnia, seizures, pseudotumor cerebri (children)

Dermatologic

Frequency not reported: Hair loss, flushing, urticaria, pruritus, skin rash, angioedema, excessive sweating

Musculoskeletal

A study evaluated the effect of long-term thyroid hormone therapy on bone mineral density in 196 women (mean age, 74.4 years) compared to a control group comprised of 795 women (mean age, 72.1 years). The mean daily thyroxine dose was 1.99 mcg/kg (range, 0.3 to 6.6 mcg/kg) with a mean duration of therapy of 20.4 years (range, less than 1 to 68 years). Women taking daily doses of 1.6 mcg/kg or more had significantly lower bone mineral density levels at the ultradistal radius, midshaft radius, hip, and lumbar spine compared to controls. However, estrogen use appeared to negate the adverse effects of thyroid hormone on bone mineral density.

Higher rates of femur fractures have been found in males (p=0.008) prescribed long-term thyroid hormone therapy as compared to controls in a case-control analysis of 23,183 patients, from the United Kingdom General Practice Research Database, prescribed thyroid hormone.

Overtreatment may result in craniosynostosis in infants and premature closure of the epiphyses in children with resultant compromised adult height.

Frequency not reported: Tremors, muscle weakness, muscle cramps, increased risk of osteoporosis, slipped capital femoral epiphysis (children)

Gastrointestinal

Frequency not reported: Diarrhea, vomiting, abdominal cramps

Genitourinary

Frequency not reported: Menstrual irregularities, impaired fertility

Hypersensitivity

Hypersensitivity reactions have occurred; however, it has been attributed to the inactive ingredients. These reactions have included urticaria, pruritus, skin rash, flushing, angioedema, various GI symptoms (abdominal pain, nausea, vomiting and diarrhea), fever, arthralgia, serum sickness and wheezing. Hypersensitivity to levothyroxine (the active ingredient contained in Synthroid) itself is not known to occur.

Frequency not reported: Serum sickness, hypersensitivity to inactive ingredients

Metabolic

Frequency not reported: Increased appetite, weight loss

Immunologic

Frequency not reported: Autoimmune disorders (e.g., chronic autoimmune thyroiditis)

Other

Frequency not reported: Fatigue, heat intolerance, fever

Psychiatric

Frequency not reported: Nervousness, anxiety, irritability, emotional lability

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Synthroid (www.drugs.com/synthroid.html).