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Sulfadiazine is an antibiotic that fights bacteria.
Sulfadiazine is used to treat many different types of infection, such as urinary tract infections, ear infections, meningitis, malaria, toxoplasmosis, and others.
Sulfadiazine may also be used for purposes not listed in this medication guide.
Do not use sulfadiazine during late pregnancy, just before you deliver.
Do not use if you are breast-feeding a baby.
You should not use sulfadiazine if you are allergic to any sulfa drug.
Do not use sulfadiazine during late pregnancy, just before you deliver.
Do not use if you are breast-feeding a baby.
Do not give sulfadiazine to a child younger than 2 months old without a doctor's advice.
To make sure sulfadiazine is safe for you, tell your doctor if you have:
kidney disease;
liver disease;
asthma, severe allergies; or
a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
FDA pregnancy category C. It is not known whether sulfadiazine will be harmful to an unborn baby. Sulfadiazine can cause severe jaundice that could lead to brain damage in your newborn if you take this medicine just before childbirth. Tell your doctor if you are pregnant.
Sulfadiazine can pass into breast milk and may harm a nursing baby. Do not breast-feed while using sulfadiazine.
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take this medicine with a full glass (8 ounces) of water. Drink plenty of liquids while you are taking sulfadiazine to keep your kidneys working properly.
Take your doses at regular intervals to keep a steady amount of the drug in your body at all times.
Do not use sulfadiazine to treat any condition that has not been checked by your doctor.
Do not share this medicine with another person, even if they have the same symptoms you have.
Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Sulfadiazine will not treat a viral infection such as the flu or a common cold.
Call your doctor if your symptoms do not improve, or if they get worse while using sulfadiazine.
While using sulfadiazine, you may need frequent blood and urine tests.
Store at room temperature away from moisture, heat, and light.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Avoid exposure to sunlight or tanning beds. Sulfadiazine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
sudden weakness or ill feeling, fever, chills, sore throat, swollen glands, joint pain, mouth sores, red or swollen gums, trouble swallowing;
pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
increased or decreased urinating, pain in your side or lower back;
hallucinations, seizure (convulsions);
liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
severe skin reaction--swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
nausea, vomiting, diarrhea, stomach pain, loss of appetite;
headache, ringing in your ears;
dizziness, spinning sensation, loss of balance or coordination;
numbness, tingling, or burning pain in your hands or feet;
sleep problems (insomnia); or
depressed mood.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with sulfadiazine, especially:
methotrexate; or
a blood thinner (warfarin, Coumadin, Jantoven).
This list is not complete. Other drugs may interact with sulfadiazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Further informationRemember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.
Source: Drugs.com Sulfadiazine Sodium (www.drugs.com/mtm/sulfadiazine.html).
Applies to sulfadiazine: oral tablet
Along with its needed effects, sulfadiazine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking sulfadiazine:
Rare
Incidence not known
Some side effects of sulfadiazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
For Healthcare Professionals
Applies to sulfadiazine: compounding powder, oral tablet
HypersensitivityHypersensitivity side effects have included urticarial rash (most common), allergic myocarditis, anaphylactoid reactions, anaphylaxis, arthralgia, conjunctival and scleral injection, drug fever and chills, epidermal necrolysis, erythema multiforme, exfoliative dermatitis, generalized skin eruptions, periorbital edema, photosensitization, serum sickness, Stevens-Johnson syndrome, and urticaria.
The use of sulfonamide antibiotics, including sulfadiazine, is associated with large increases in the risk of Stevens-Johnson syndrome and toxic epidermal necrolysis, although these phenomena are rare as a whole.
HematologicHematologic side effects have included agranulocytosis (0.1%), aplastic anemia, hemolytic anemia (0.05%), hypoprothrombinemia, leukopenia, methemoglobinemia, and purpura.
Hemolytic anemia occurs less often with sulfadiazine than with other sulfonamides. Aplastic anemia may be more likely in patients with poor bone marrow reserves.
GastrointestinalGastrointestinal side effects have included nausea, vomiting, abdominal pain, diarrhea, anorexia, pancreatitis, and stomatitis.
HepaticHepatic side effects are rare but can be serious. Isolated cases of hepatitis and jaundice due to cholestasis have been associated with sulfadiazine. Elevated liver function tests (with a negative hepatitis panel) have been reported in at least one case associated with psychosis.
PsychiatricPsychosis associated with sulfadiazine and pyrimethamine therapy in patients with AIDS and CNS toxoplasmosis has been described in two separate case reports. In each case, tremulousness and disorientation developed within three days to two weeks after starting therapy, despite partial resolution of the size of the intracranial T gondii lesions. No other obvious cause for mental status changes was found. The delirium resolved upon discontinuation of therapy in each case, and was reproducible upon rechallenge. In one case, the patient had elevated liver function tests (hepatitis panel was negative), which were reversible upon discontinuation of therapy.
Psychiatric side effects have rarely included frank psychosis in patients with AIDS and CNS toxoplasmosis. Tremulousness, disorientation, and delirium have been reported.
Nervous systemNervous system side effects have included ataxia, convulsions, hallucinations, headache, insomnia, mental depression, peripheral neuritis, tinnitus, and vertigo.
RenalRenal side effects have included crystalluria, lupus erythematosus, periarteritis nodosa, toxic nephrosis with oliguria and anuria, and acute renal failure secondary to crystalluria or tubulointerstitial nephritis.
GenitourinaryIn one case, analysis of the stone fragments showed a composition of 100% acetylated 2-sulfanilamidopyrimidine, a metabolite of sulfadiazine.
Genitourinary side effects have included urolithiasis.
MetabolicMetabolic side effects have included hypoglycemia.
EndocrineEndocrine side effects associated with sulfonamides have rarely included diuresis, goiter production, and sialadenitis.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.
Source: Drugs.com Sulfadiazine Sodium (www.drugs.com/mtm/sulfadiazine.html).
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