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Sufentanil Citrate

Sufentanil citrate Prescription
Generic Name: Sufentanil Injection (soo FEN ta nil)
Easy-to-read patient leaflet for Sufentanil Injection. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Sufentanil Citrate Drug Information:

This is not a list of all drugs or health problems that interact with sufentanil injection. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take sufentanil injection with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use sufentanil injection as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

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Sufentanil Citrate Side Effects

For the Consumer

Applies to sufentanil: sublingual tablet

Other dosage forms:

  • injection solution

Sublingual route (Tablet)

Accidental exposure to or ingestion of sufentanil sublingual tablets, especially in children, can result in respiratory depression and death. Because of the potential for life-threatening respiratory depression due to accidental exposure, sufentanil sublingual tablets are only available through a restricted program called the Dsuvia REMS Program. Sufentanil sublingual tablets must only be dispensed to patients in a certified medically supervised healthcare setting. Discontinue use of sufentanil sublingual tablets prior to discharge or transfer from the certified medically supervised healthcare setting.Serious, life-threatening, or fatal respiratory depression may occur with the use of sufentanil sublingual tablets. Monitor for respiratory depression, especially during initiation of sufentanil sublingual tablets.Sufentanil sublingual tablets exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient's risk prior to prescribing sufentanil sublingual tablets, and monitor all patients regularly for the development of these behaviors or conditions.Concomitant use with CYP3A4 inhibitors (or discontinuation of CYP3A4 inducers) can result in a fatal overdose of sufentanil.Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants including alcohol, may result in profound sedation, respiratory depression coma, and death. Reserve concomitant prescribing for use in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation.

Side effects requiring immediate medical attention

Along with its needed effects, sufentanil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking sufentanil:

Less common

  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating
  • unusual tiredness or weakness


  • Bloody urine
  • blue lips, fingernails, or skin
  • burning feeling in the chest or stomach
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • decreased frequency or amount of urine
  • decreased urine output
  • difficult or troubled breathing
  • difficulty in passing urine (dribbling)
  • extremely shallow or slow breathing
  • fainting
  • fast heartbeat
  • increased blood pressure
  • increased thirst
  • indigestion
  • irregular, fast or slow, or shallow breathing
  • lightheadedness, dizziness or fainting
  • loss of appetite
  • lower back or side pain
  • nausea
  • painful urination
  • seeing, hearing, or feeling things that are not there
  • severe constipation
  • severe vomiting
  • slow or irregular heartbeat
  • stomach pain or upset
  • swelling of the face, fingers, or lower legs
  • tenderness in the stomach area
  • troubled breathing
  • unusual drowsiness, dullness, or feeling of sluggishness
  • vomiting
  • weakness
  • weight gain

Incidence not known

  • Agitation
  • cough
  • darkening of the skin
  • diarrhea
  • difficulty swallowing
  • fever
  • hives, itching, skin rash
  • mental depression
  • overactive
  • reflexes
  • poor coordination
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • restlessness
  • shivering
  • talking or acting with excitement you cannot control
  • tightness in the chest
  • trembling or shaking
  • twitching

Get emergency help immediately if any of the following symptoms of overdose occur while taking sufentanil:

Symptoms of overdose

  • Blue lips and fingernails
  • blurred vision
  • chest pain
  • choking
  • cold and clammy skin
  • constricted pupils
  • coughing that sometimes produces a pink frothy sputum
  • decreased awareness or responsiveness
  • difficult or troubled breathing
  • irregular, fast or slow, or shallow breathing
  • loss of consciousness
  • pale or blue lips, fingernails, or skin
  • severe sleepiness
  • slow heartbeat
  • swelling in the legs and ankles
Side effects not requiring immediate medical attention

Some side effects of sufentanil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Headache


  • Anxiety
  • belching
  • bloated
  • confusion about identity, place, and time
  • difficulty having a bowel movement (stool)
  • drowsiness
  • dry mouth
  • excess air or gas in the stomach or bowels
  • false or unusual sense of well-being
  • feeling of warmth
  • forgetfulness
  • full feeling
  • heartburn
  • indigestion
  • muscle spasm
  • passing gas
  • redness of the face, neck, arms and occasionally, upper chest
  • sleepiness or unusual drowsiness
  • trouble sleeping

For Healthcare Professionals

Applies to sufentanil: compounding powder, injectable solution, sublingual tablet


The most commonly reported adverse events with the sublingual tablet have been nausea, headache, vomiting, dizziness, and hypotension; with the injectable formulation, apnea, rigidity, and bradycardia have been commonly reported.


Common (1% to 10%): Respiratory depression

Uncommon (0.1% to 1%): Apnea

Rare (less than 0.1%): Hypoxia, bradypnea, hiccups, atelectasis, hypoventilation, respiratory distress, respiratory failure

Frequency not reported: Respiratory arrest


Anaphylaxis has been reported with ingredients contained in the sufentanil sublingual tablet.

Uncommon (0.1% to 1%): Hypersensitivity

Postmarketing reports: Anaphylaxis


Common (1% to 10%): Increased heart rate, increased blood pressure, decreased blood pressure

Uncommon (0.1% to 1%): Decreased heart rate, hypotension

Rare (less than 0.1%):: Bradycardia, sinus tachycardia, flushing

Frequency not reported: Severe bradycardia, severe hypotension including orthostatic hypotension, syncope


Common (1% to 10%): Involuntary muscle spasms, muscle twitching

Frequency not reported: Muscle rigidity, muscle movement


Very common (10% or more): Nausea (29%; sublingual tablet), vomiting

Common (1% to 10%): Constipation, dyspepsia

Uncommon (0.1% to 1%): Dry mouth

Rare (less than 0.1%): Flatulence, diarrhea, dry mouth, eructation, retching, abdominal discomfort, abdominal distension, abdominal pain upper, gastritis, postoperative ileus, hypoesthesia oral


Frequency not reported: increase in serum amylase


Common (1% to 10%): Confusional state

Uncommon (0.1% to 1%): Apathy, nervousness

Rare (less than 0.1%): Memory impairment, insomnia, confusional state, anxiety, agitation, disorientation, euphoric mood, hallucination, mental status changes

Frequency not reported: Addiction, abuse, misuse

Nervous system

Cases of serotonin syndrome have been reported during concomitant use of opioids with serotonergic drugs.

Very common (10% or more): Headache (12.1%; sublingual tablet)

Common (1% to 10%): Dizziness, sedation

Uncommon (0.1% to 1%): Somnolence, paresthesia, ataxia, dystonia, hyperreflexia

Rare (less than 0.1%): Pre-syncope, lethargy

Frequency not reported: Seizures, coma


Postmarketing reports: Serotonin syndrome


Very common (10% or more): Pruritus (up to 25%)

Uncommon (0.1% to 1%): Hyperhidrosis, rash, dry skin

Frequency not reported: Erythema


Common (1% to 10%): Urinary retention

Rare (less than 0.1%): urinary hesitation, oliguria


Uncommon (0.1% to 1%): Vision disturbances

Frequency not reported: Miosis


Very common (10% or more): Pyrexia

Uncommon (0.1% to 1%): Chills, asthenia

Frequency not reported: Drug withdrawal syndrome


Cases of adrenal insufficiency have been reported with opioid use of greater than 1-month duration. Cases of androgen deficiency have occurred with chronic opioid use.


Postmarketing reports: Adrenal insufficiency, androgen deficiency


Rare (less than 0.1%): Renal failure

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Sufentanil Citrate (www.drugs.com/cdi/sufentanil-injection.html).