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Generic Name: avanafil (a VAN a fil)
Brand Names: Stendra
Stendra (avanafil) is used on an as-needed basis to treat erectile dysfunction (impotence). Includes Stendra side effects, interactions and indications.
Generic Name: avanafil (a VAN a fil)
Brand Names: Stendra
Stendra (avanafil) is used on an as-needed basis to treat erectile dysfunction (impotence). Includes Stendra side effects, interactions and indications.
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30 tablets of Stendra 40 mg
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Stendra Drug Information:

Stendra (avanafil) relaxes muscles found in the walls of blood vessels and increases blood flow to particular areas of the body. Stendra is used to treat erectile dysfunction (impotence). Stendra should not be taken by a woman or a child. Taking Stendra with certain other medicines can cause a sudden and serious decrease in blood pressure. Do not take avanafil if you also take riociguat (Adempas) or a nitrate drug such as Nitroglycerin, Isosorbide Dinitrate, or Isosorbide Mononitrate. If you become dizzy or nauseated during sexual activity, or if you have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect. Learn more

Stendra Side Effects

Note: This document contains side effect information about avanafil. Some of the dosage forms listed on this page may not apply to the brand name Stendra.

In Summary

Common side effects of Stendra include: headache and flushing. Other side effects include: nasopharyngitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to avanafil: oral tablet

Along with its needed effects, avanafil (the active ingredient contained in Stendra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking avanafil:

Less common

  • Blurred vision
  • dizziness
  • headache
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat


  • Arm, back, or jaw pain
  • bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • chest pain or discomfort
  • chest tightness or heaviness
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • fast, irregular, pounding, or racing heartbeat or pulse
  • frequent urge to urinate
  • increased erection
  • lower back or side pain
  • nausea and vomiting
  • pain in the groin or genitals
  • pain, redness, or swelling in the arm or leg
  • rapid weight gain
  • sharp back pain just below the ribs
  • sweating
  • tightness in the chest
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss

Some side effects of avanafil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Feeling of warmth
  • fever
  • muscle aches
  • redness of the face, neck, arms, and occasionally, upper chest
  • sore throat
  • stuffy or runny nose

Less common

  • Acid or sour stomach
  • belching
  • body aches or pain
  • change in color vision
  • chills
  • cough
  • cough producing mucus
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • ear congestion
  • heartburn
  • indigestion
  • joint pain
  • loss of appetite
  • loss of voice
  • muscle pain or stiffness
  • pain or tenderness around the eyes and cheekbones
  • rash
  • shivering
  • sneezing
  • sweating
  • trouble sleeping


  • Anxiety
  • bloody nose
  • bone pain
  • burning feeling in the chest or stomach
  • confusion
  • cool, pale skin
  • depression
  • feeling of constant movement of self or surroundings
  • increased hunger
  • itching skin
  • muscle aching or cramping
  • muscle spasms
  • nightmares
  • seizures
  • sensation of spinning
  • shakiness
  • sleepiness or unusual drowsiness
  • slurred speech
  • swollen joints
  • tenderness in the stomach area

For Healthcare Professionals

Applies to avanafil: oral tablet


The most common side effects reported were headache, flushing, nasal and sinus congestion and back pain.


Very common (10% or more): Flushing (up to 10.1%)

Common (1% to 10%): Hypertension, abnormal electrocardiogram

Uncommon (0.1% to 1%): Peripheral edema, angina, unstable angina, deep vein thrombosis, palpitations, hot flush, increased heart rate

Rare (less than 0.1%): Tachycardia, chest pain, increased blood pressure, cardiac murmur

Postmarketing reports: Hypotension


Uncommon (0.1% to 1%): Balanitis, increased erection

Rare (less than 0.1%): Penis disorder, spontaneous penile erection, genital pruritus, increased prostate specific antigen

Postmarketing reports: Priapism, hematuria, hematospermia, penile hemorrhage


Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Pruritus


Common (1% to 10%): Diarrhea, dyspepsia, nausea, constipation

Uncommon (0.1% to 1%): Gastritis, gastroesophageal reflux disease, stomach discomfort, vomiting, dyspepsia, nausea

Rare (less than 0.1%): Dry mouth, lower abdominal pain


Common (1% to 10%): Back pain, arthralgia

Uncommon (0.1% to 1%): Muscle spasms, musculoskeletal pain, myalgia, pain in extremity, muscle tightness

Rare (less than 0.1%): Flank pain

Nervous system

Very common (10% or more): Headache (up to 12.1%)

Common (1% to 10%): Dizziness

Uncommon (0.1% to 1%): Somnolence, vertigo, sinus headache

Rare (less than 0.1%): Psychomotor hyperactivity


Uncommon (0.1% to 1%): Depression, insomnia

Rare (less than 0.1%): Premature ejaculation, inappropriate affect


Uncommon (0.1% to 1%): Hematuria, nephrolithiasis, pollakiuria, urinary tract infection

Rare (less than 0.1%): Blood urine present


Common (1% to 10%): Nasal congestion, nasopharyngitis, upper respiratory infection (URI), bronchitis, sinusitis, sinus congestion

Uncommon (0.1% to 1%): Oropharyngeal pain, cough, exertional dyspnea, wheezing

Rare (less than 0.1%): Rhinorrhea, upper respiratory tract congestion


Uncommon (0.1% to 1%): Epistaxis


Uncommon (0.1% to 1%): Increased alanine aminotransferase

Rare (less than 0.1%): Increased blood bilirubin


Common (1% to 10%): Influenza

Rare (less than 0.1%): Seasonal allergy


Uncommon (0.1% to 1%): Hypoglycemia, increased blood glucose

Rare (less than 0.1%): Gout, Increased weight


Uncommon (0.1% to 1%): Blurred vision, vision loss

Postmarketing reports: Non-arteritic anterior ischemic optic neuropathy (NAION)


Uncommon (0.1% to 1%): Fatigue, tinnitus

Rare (less than 0.1%): Asthenia, influenza-like illness, increased body temperature

Postmarketing reports: Loss of hearing

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Stendra (www.drugs.com/stendra.html).