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Starlix

Generic Name: nateglinide (oral) (na ta GLYE nide)
Brand Names: Starlix
Starlix is used together with diet and exercise to treat type 2 diabetes. Learn about side effects, interactions and indications.
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Drug Information:
Starlix (nateglinide) is an oral diabetes medicine that helps control blood sugar levels. This medicine helps your body respond better to insulin produced by your pancreas. Starlix is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes. Other diabetes medicines are sometimes used in combination with Starlix if needed. You should not use Starlix if you have diabetic ketoacidosis (call your doctor for treatment). Learn more

Starlix Side Effects

Starlix Side Effects

Note: This document contains side effect information about nateglinide. Some of the dosage forms listed on this page may not apply to the brand name Starlix.

For the Consumer

Applies to nateglinide: oral tablet

Along with its needed effects, nateglinide (the active ingredient contained in Starlix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nateglinide:

Less common

  • Convulsions (seizures)
  • unconsciousness

Check with your doctor as soon as possible if any of the following side effects occur while taking nateglinide:

Less common

  • Low blood sugar, including anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in thinking, drowsiness, excessive hunger, fast heartbeat, headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, or unusual tiredness or weakness

Incidence not known-occurred during clinical practice

  • Hives or welts
  • itching
  • redness of skin
  • skin rash

Some side effects of nateglinide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Cough
  • runny or stuffy nose
  • sore throat

Less common

  • Abdominal or stomach pain
  • back pain
  • chills
  • dizziness
  • pain in joints or muscles
  • sneezing
  • swelling in joints

For Healthcare Professionals

Applies to nateglinide: oral tablet

General

The most frequently reported adverse events included upper respiratory tract infections and symptoms of hypoglycemia.

Metabolic

Common (1% to 10%): Hypoglycemia

Frequency not reported: Increases in mean uric acid level

Hypoglycemia has been reported and has generally been mild and corrected by intake of carbohydrates. In comparative clinical trials, hypoglycemia was reported in 10.4%, 14.5%, 6.9%, 19.8%, and 4.1% in patients receiving nateglinide alone, nateglinide plus metformin, metformin alone, glyburide alone, and placebo, respectively.

Mean uric acid levels were increased in patient receiving this drug as monotherapy. The difference from placebo in treated patients was 0.29 mg/dL, 0.45 mg/dL, 0.28 mg/dL, and 0.19 mg/dL in patients receiving nateglinide alone, nateglinide plus metformin, metformin alone, glyburide alone, respectively. The clinical significance of these findings is unknown.

Respiratory

Common (1% to 10%): Upper respiratory tract infection, bronchitis, coughing

Hypersensitivity

Postmarketing reports: Hypersensitivity reactions such as rash, itching, and urticaria

Gastrointestinal

Common (1% to 10%): Diarrhea, abdominal pain, dyspepsia, nausea

Uncommon (0.1% to 1%): Vomiting

Gastrointestinal symptoms, especially diarrhea and nausea, were no more common in patients using this drug in combination with metformin than in patients receiving metformin alone.

Hepatic

Postmarketing reports: Elevated liver enzymes, jaundice, cholestatic hepatitis

Nervous system

Common (1% to 10%): Dizziness

Musculoskeletal

Common (1% to 10%): Back pain, arthropathy

Cardiovascular

Peripheral edema was no more common in patients using this drug in combination with rosiglitazone than in patients receiving rosiglitazone alone.

Frequency not reported: Peripheral edema

Dermatologic

Postmarketing reports: Erythema multiforme

Immunologic

Common (1% to 10%): Flu symptoms

Other

Common (1% to 10%): Accidental trauma

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Starlix (www.drugs.com/starlix.html).