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Applies to spironolactone: oral suspension, oral tablet
Along with its needed effects, spironolactone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking spironolactone:
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking spironolactone:
Symptoms of overdose
Some side effects of spironolactone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
For Healthcare Professionals
Applies to spironolactone: compounding powder, oral suspension, oral tablet
GeneralThe most common adverse effect was gynecomastia.
EndocrineVery common (10% or more): Gynecomastia (13%)
Frequency not reported: Breast disorders in women, slight androgenic effects, breast tenderness in women, voice deepening in women, breast pain
MetabolicCommon (1% to 10%): Hyperkalemia, hyponatremia
Uncommon (0.1% to 1%): Acidosis in patients with liver problems
Rare (less than 0.1%): Dehydration, porphyria, hyperuricemia
Frequency not reported: Reversible hyperchloremic metabolic acidosis in patients with decompensated hepatic cirrhosis, electrolyte disturbances
GenitourinaryCommon (1% to 10%): Changes in vaginal secretions, amenorrhea, postmenopausal bleeding
Frequency not reported: Reproductive system disorders, erectile dysfunction, impotence, menstrual disorders
Nervous systemCommon (1% to 10%): Lethargy in patients with cirrhosis, paresthesia
Rare (less than 0.1%): Paralysis, paraplegia of the limbs due to hyperkalemia
Frequency not reported: Headache, drowsiness, dizziness, ataxia
GastrointestinalCommon (1% to 10%): Nausea, vomiting
Very rare (less than 0.01%): Gastric inflammation, gastric ulcers, intestinal hemorrhage, cramps
Frequency not reported: Digestive system disorders, diarrhea, indigestion, gastric bleeding
PsychiatricCommon (1% to 10%): Libido reduced in women
Uncommon (0.1% to 1%): Confusion
Frequency not reported: Libido reduced in men
OncologicCommon (1% to 10%): Malaise
Very rare (less than 0.01%): Breast cancer
OtherCommon (1% to 10%): Weakness
Frequency not reported: Fatigue, fever
DermatologicUncommon (0.1% to 1%): Rash, urticaria, erythema, chloasma, pruritus, exanthema
Rare (less than 0.1%): Eczema
Very rare (less than 0.01%): Alopecia, erythema annulare centrifugum, hypertrichosis
Frequency not reported: Hirsutism, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms (DRESS), maculopapular or erythematous cutaneous eruptions
MusculoskeletalUncommon (0.1% to 1%): Muscle spasms, leg cramps
Very rare (less than 0.01%): Systemic lupus erythematosus, osteomalacia
RenalUncommon (0.1% to 1%): Serum creatinine elevated
Rare (less than 0.1%): BUN increased
Very rare (less than 0.01%): Acute renal failure
Frequency not reported: Renal dysfunction
HematologicRare (less than 0.1%): Thrombocytopenia, eosinophilia, leukopenia
Frequency not reported: Agranulocytosis
ImmunologicRare (less than 0.1%): Hypersensitivity
Frequency not reported: Anaphylactic reactions
CardiovascularVery rare (less than 0.01%): Vasculitis
Frequency not reported: Mild hypotension
HepaticVery rare (less than 0.01%): Hepatitis
Frequency not reported: Mixed cholestatic/hepatocellular toxicity
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Spironolactone (www.drugs.com/spironolactone.html).
June 22, 2021
December 2, 2021
June 24, 2021
December 1, 2020
September 2, 2020
February 12, 2020