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Applies to sodium phenylbutyrate: oral powder, oral tablet
Along with its needed effects, sodium phenylbutyrate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking sodium phenylbutyrate:
More common
Less common
Rare
Some side effects of sodium phenylbutyrate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Rare
For Healthcare Professionals
Applies to sodium phenylbutyrate: oral powder for reconstitution, oral tablet
GeneralCausality of adverse effects is sometimes difficult to determine because they may result from either the underlying disease, the patient's restricted diet, intercurrent illness, or the drug itself.
EndocrineVery common (10% or more): Amenorrhea/menstrual dysfunction (23%)
MetabolicVery common (10% or more): Acidosis (14%), hypoalbuminemia (11%)
Common (1% to 10%): Alkalosis, decreased appetite, hyperchloremia, hypophosphatemia, decreased total protein, hyperuricemia, hyperphosphatemia, hypernatremia, hypokalemia, increased weight
CardiovascularCommon (1% to 10%): Edema
Uncommon (0.1% to 1%): Arrhythmia
DermatologicCommon (1% to 10%): Rash, body odor
GastrointestinalCommon (1% to 10%): Abdominal pain, nausea, vomiting, constipation, dysgeusia
Uncommon (0.1% to 1%): Pancreatitis, rectal bleeding/hemorrhage, peptic ulcer, gastritis
HematologicCommon (1% to 10%): Anemia, leukopenia, leukocytosis, thrombocytopenia, thrombocytosis
Uncommon (0.1% to 1%): Aplastic anemia, ecchymosis
HepaticCommon (1% to 10%): Increased alkaline phosphatase, increased liver transaminases, hyperbilirubinemia
Nervous systemCommon (1% to 10%): Syncope, headache, bad taste/taste aversion
Frequency not reported: Somnolence, fatigue, lightheadedness, hypoacusis, disorientation, impaired memory, exacerbation of preexisting neuropathy
PsychiatricCommon (1% to 10%): Depression, irritability
RenalCommon (1% to 10%): Renal tubular acidosis
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Sodium Phenylbutyrate (www.drugs.com/mtm/sodium-phenylbutyrate.html).
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