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Sivextro

Generic Name: tedizolid (oral/injection) (te DIZ oh lid)
Brand Names: Sivextro
Sivextro (tedizolid) is used to treat acute bacterial skin and skin structure infections, including MRSA staph infections. Includes Sivextro side effects, interactions and indications.
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Drug Information:
Sivextro (tedizolid) is an antibiotic that fights bacteria. Sivextro is used to treat skin infections in adults, including "MRSA" staph infections. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Sivextro and other antibacterial drugs, this medicine should only be used to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. Sivextro should only be used to treat bacterial infections. Tedizolid does not treat viral infections (e.g., the common cold). Learn more

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Sivextro Side Effects

Note: This document contains side effect information about tedizolid. Some of the dosage forms listed on this page may not apply to the brand name Sivextro.

In Summary

More frequent side effects include: diarrhea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to tedizolid: oral tablet

Other dosage forms:

  • intravenous powder for solution

Along with its needed effects, tedizolid (the active ingredient contained in Sivextro) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tedizolid:

Less common or rare

  • Abdominal or stomach tenderness
  • back pain
  • blurred vision
  • chest tightness
  • chills
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • hives or welts, itching, or skin rash
  • hoarseness
  • joint pain, stiffness, or swelling
  • nausea and vomiting
  • nervousness
  • pale skin
  • pounding in the ears
  • redness of the skin
  • severe abdominal or stomach cramps and pain
  • slow or fast heartbeat
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • watery or severe diarrhea, which may also be bloody

Some side effects of tedizolid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Burning, numbness, tingling, or painful sensations
  • diarrhea
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

Less common or rare

  • Blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in vision
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally, upper chest
  • seeing floating spots before the eyes
  • sore mouth or tongue
  • trouble sleeping
  • white patches in the mouth or on the tongue

For Healthcare Professionals

Applies to tedizolid: intravenous powder for injection, oral tablet

General

The most common side effects were nausea, headache, diarrhea, vomiting, and dizziness. Median time to onset was 5 days.

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea, vomiting

Uncommon (0.1% to 1%): Clostridium difficile colitis, oral candidiasis, abdominal pain, constipation, abdominal discomfort, dry mouth, dyspepsia, upper abdominal pain, flatulence, gastroesophageal reflux disease, hematochezia, retching

Nervous system

Common (1% to 10%): Headache, dizziness, peripheral neuropathy

Uncommon (0.1% to 1%): Somnolence, dysgeusia, tremor, hypoesthesia, paresthesia

Frequency not reported: VIIth nerve paralysis

Hematologic

Common (1% to 10%): Decreased hemoglobin, decreased platelet count

Uncommon (0.1% to 1%): Decreased absolute neutrophil count, lymphadenopathy, decreased WBC count

Frequency not reported: Anemia

Decreased hemoglobin (less than 10.1 g/dL in males; less than 9 g/dL in females), platelet count (less than 112 x 10[3]/mm3), and absolute neutrophil count (less than 0.8 x 10[3]/mm3) were reported in 3.4%, 2.1%, and 0.4% of patients, respectively.

Dermatologic

Common (1% to 10%): Generalized pruritus

Uncommon (0.1% to 1%): Dermatophytosis, pruritus, urticaria, hyperhidrosis, rash, alopecia, erythematous rash, generalized rash, acne, allergic pruritus, maculopapular rash, popular rash, pruritic rash

Frequency not reported: Dermatitis

Other

Common (1% to 10%): Fatigue

Uncommon (0.1% to 1%): Fungal infection, abscess, flushing, hot flush, chills, pyrexia, peripheral edema, grip strength decreased

Local

Common (1% to 10%): Infusion/injection-related side effects (including but not limited to phlebitis, injection/infusion-site pain, injection/infusion-site swelling, injection-site reaction, injection-site erythema, injection-site induration, infusion-related reaction), infusion site reactions (phlebitis)

Uncommon (0.1% to 1%): Infusion-related reactions, infusion site pain

Cardiovascular

Uncommon (0.1% to 1%): Bradycardia

Frequency not reported: Palpitations, tachycardia, hypertension

Hepatic

Uncommon (0.1% to 1%): Elevated hepatic transaminases

Frequency not reported: Increased ALT, increased AST, increased GGT

Psychiatric

Uncommon (0.1% to 1%): Insomnia, sleep disorder, anxiety, nightmare, irritability

Hypersensitivity

Uncommon (0.1% to 1%): Drug hypersensitivity

Musculoskeletal

Uncommon (0.1% to 1%): Arthralgia, muscle spasms, back pain, limb discomfort, neck pain

Metabolic

Uncommon (0.1% to 1%): Dehydration, inadequately controlled diabetes mellitus, hyperkalemia

Ocular

Uncommon (0.1% to 1%): Optic nerve disorders, blurred vision, vitreous floaters

Frequency not reported: Asthenopia, visual impairment

Respiratory

Uncommon (0.1% to 1%): Respiratory tract infection, cough, nasal dryness, pulmonary congestion

Genitourinary

Uncommon (0.1% to 1%): Vulvovaginal mycotic infection, vulvovaginal candidiasis, abnormal urine odor, vulvovaginal pruritus

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Sivextro (www.drugs.com/sivextro.html).