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Sirturo

Generic Name: bedaquiline (bed AK wi leen)
Brand Names: Sirturo
Sirturo (bedaquiline) is an antibiotic used to treat multi-drug resistant tuberculosis. Includes Sirturo side effects, interactions and indications.
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Drug Information:
Sirturo (bedaquiline) is an antibiotic that fights bacteria. Sirturo is used together with other medications to treat tuberculosis of the lungs that has been resistant to other antibacterial medications. Sirturo is for use in adults and children at least 12 years old and weighing at least 66 pounds (30 kilograms). Sirturo can cause serious and sometimes fatal side effects. This medicine should be used only if you have no other treatment options. Sirturo can cause serious and sometimes fatal side effects. This medicine should be used only if you have no other treatment options. Use only the prescribed dose of this medication, and follow all patient instructions for safe use. Learn more

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Sirturo Side Effects

Note: This document contains side effect information about bedaquiline. Some of the dosage forms listed on this page may not apply to the brand name Sirturo.

In Summary

Common side effects of Sirturo include: headache and nausea. Other side effects include: hepatic insufficiency, increased liver enzymes, increased serum alanine aminotransferase, increased serum aspartate aminotransferase, increased serum transaminases, and anorexia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to bedaquiline: oral tablet

Warning

Oral route (Tablet)

Only use bedaquiline when an effective treatment regimen cannot otherwise be provided due to an increased risk of unexplained death in bedaquiline-treated patients compared with placebo in a controlled trial. Prolongation of the QT interval may occur with bedaquiline, especially with concomitant use of other QT prolonging drugs. Monitor ECG prior to and during treatment, and discontinue if significant ventricular arrhythmia or if a QTc interval of greater than 500 milliseconds develops.

Along with its needed effects, bedaquiline (the active ingredient contained in Sirturo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking bedaquiline:

More common

  • Abdominal or stomach pain or tenderness
  • chest pain
  • coughing or spitting up blood
  • dark-colored urine
  • decreased appetite
  • fever
  • general feeling of tiredness or weakness
  • headache
  • itching
  • light-colored stools
  • loss of appetite
  • nausea and vomiting
  • skin rash
  • swelling of the feet or lower legs
  • unusual tiredness or weakness
  • yellow eyes or skin

Incidence not known

  • Fainting
  • irregular heartbeat recurrent

Some side effects of bedaquiline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty with moving
  • muscle pain or stiffness
  • pain in the joints

For Healthcare Professionals

Applies to bedaquiline: oral tablet

Other

Very common (10% or more): Increased mortality risk/death (up to 12.7%), chest pain (up to 11%)

Cardiovascular

Common (1% to 10%): QT prolongation

Hepatic

Very common (10% or more): Elevated aminotransferases at least 3 times ULN (up to 10.8%)

Common (1% to 10%): Hepatotoxicity (increased ALT, increase AST, increased hepatic enzyme, abnormal hepatic function)

Gastrointestinal

Very common (10% or more): Nausea (up to 38%), vomiting (up to 20.6%)

Common (1% to 10%): Diarrhea, increased blood amylase

Musculoskeletal

Very common (10% or more): Arthralgia (up to 33%)

Common (1% to 10%): Myalgia

Nervous system

Very common (10% or more): Headache (up to 28%), dizziness (up to 12.7%)

Respiratory

Very common (10% or more): Hemoptysis (up to 18%)

Metabolic

Common (1% to 10%): Anorexia

Dermatologic

Common (1% to 10%): Rash

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Sirturo (www.drugs.com/sirturo.html).