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Signifor LAR is a man-made protein that is similar to a hormone in the body called somatostatin.
Signifor LAR is used to treat Cushing's disease or acromegaly (endocrine disorders). This medicine is usually given after surgery or other treatments did not work or have stopped working.
Signifor LAR may also be used for purposes not listed in this medication guide.
Signifor LAR may lower your cortisol levels. Tell your doctor if you have symptoms such as nausea, vomiting, appetite changes, headache, irritability, confusion, slurred speech, or feeling weak, tired, unsteady, anxious, shaky, or light-headed.
Signifor LAR can raise your blood sugar and may cause diabetes. Your blood sugar may need to be tested before and during treatment with Signifor LAR. Call your doctor if you have increased thirst or urination, tiredness, and weight loss even if you are more hungry than usual.
You should not use Signifor LAR if you are allergic to it.
Tell your doctor if you have ever had:
diabetes, or high blood sugar;
liver disease;
heart problems;
gallstones; or
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
It is not known whether Signifor LAR will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Signifor LAR may alter hormone levels in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.
You should not breast-feed while using Signifor LAR.
Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using Signifor LAR.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Signifor LAR is injected under the skin or into a muscle. A healthcare provider can teach you how to properly use the medication by yourself.
Signifor LAR is injected into a muscle once every 4 weeks. A healthcare provider will give you this type of pasireotide injection.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.
Your care provider will show you where on your body to inject Signifor LAR. Use a different place each time you give an injection. Do not inject into the same place two times in a row. Avoid skin that is red or irritated.
Signifor LAR can raise your blood sugar, and may cause diabetes. Your blood sugar may need to be tested regularly while you are using Signifor LAR. You will also need frequent medical tests, including an occasional ultrasound or electrocardiograph or ECG (sometimes called an EKG).
Store Signifor at room temperature, away from moisture, heat, and light. Throw away an ampule after one use, even if there is still medicine left inside.
If you store Signifor LAR at home, keep it in the original carton in the refrigerator. Do not freeze. Take the medicine out of the refrigerator and let it reach room temperature for 30 minutes before injecting your dose. Do not leave the medicine out for longer than 24 hours.
Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.
Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
fast or slow heartbeats;
sudden dizziness (like you might pass out);
low cortisol levels--nausea, vomiting, appetite changes, headache, irritability, confusion, slurred speech, or feeling weak, tired, unsteady, anxious, shaky, or light-headed;
high blood sugar--increased thirst, increased urination, fruity breath odor, tiredness, and weight loss even if you are more hungry than usual; or
gallbladder problem--chalky-colored stools, stomach pain just after eating a meal, heartburn, bloating, and upper stomach pain that may spread to your back.
Common side effects may include:
abnormal blood test results;
feeling weak or tired;
nausea, stomach pain, diarrhea;
headache;
swelling, rapid weight gain;
cold symptoms such as stuffy nose and sneezing;
hair loss; or
pain, redness, itching, bruising or bleeding where the medicine was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Signifor LAR can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
Tell your doctor about all your current medicines. Many drugs can affect Signifor LAR, especially:
bromocriptine;
cyclosporine;
heart or blood pressure medication; or
medicines to control blood levels of magnesium or potassium.
This list is not complete and many other drugs may affect Signifor LAR. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Signifor Lar (www.drugs.com/mtm/signifor-lar.html).
Note: This document contains side effect information about pasireotide. Some of the dosage forms listed on this page may not apply to the brand name Signifor LAR.
Common side effects of Signifor LAR include: asthenia, cholelithiasis, fatigue, hypoglycemia, increased serum alanine aminotransferase, nausea, and vomiting. Other side effects include: adrenocortical insufficiency, hypotension, and increased serum glucose. See below for a comprehensive list of adverse effects.
Applies to pasireotide: powder for suspension, solution
Along with its needed effects, pasireotide (the active ingredient contained in Signifor LAR) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking pasireotide:
More common
Incidence not known
Some side effects of pasireotide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Applies to pasireotide: intramuscular powder for injection extended release, subcutaneous solution
Very common (10% or more): Hypertension (10%)
Common (1% to 10%): Hypotension (7%), prolonged QT (6%), sinus bradycardia (6%)
Very common (10% or more): Alopecia (12%)
Common (1% to 10%): Pruritus (8%), dry skin (6%)
Common (1% to 10%): Adrenal insufficiency (6%)
Very common (10% or more): Diarrhea (58%), nausea (52%), abdominal pain (24%), upper abdominal pain (10%)
Common (1% to 10%): Constipation (7%), vomiting (7%), abdominal distention (6%)
Very common (10% or more): Asthenia (11%), peripheral edema (10%), decreased appetite (10%)
Very common (10% or more): Elevated PTT (47%), elevated PT (33%)
Common (1% to 10%): Anemia
Very common (10% or more): Cholelithiasis (30%), alanine aminotransferase increased (10%), gamma-glutamyl transferase increased (10%)
Common (1% to 10%): Aspartate aminotransferase increased (6%)
Very common (10% or more): Injection site reactions (17%)
Very common (10% or more): Hyperglycemia (40%), diabetes mellitus (18%), glycosylated hemoglobin increased (11%), hypercholesterolemia (10%)
Common (1% to 10%): Hypoglycemia (9%), Type 2 diabetes mellitus (9%), lipase increased (7%), hypokalemia (6%), blood glucose increased (6%), blood amylase increased (2%)
Common (1% to 10%): Myalgia (9%), arthralgia (8%), back pain (6%), pain in extremity (6%)
Very common (10% or more): Headache (28%), fatigue (19%)
Common (1% to 10%): Dizziness (9%), anxiety (9%), insomnia (9%), vertigo (6%)
Very common (10% or more): Nasopharyngitis (13%)
Common (1% to 10%): Influenza (9%)
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Signifor Lar (www.drugs.com/mtm/signifor-lar.html).
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