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Sevelamer Carbonate

Sevelamer carbonate Prescription
Generic Name: sevelamer (se VEL a mer)
Brand Name: Renagel, Renvela
Physician reviewed sevelamer patient information - includes sevelamer description, dosage and directions.
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Sevelamer Carbonate Drug Information:

Sevelamer is a phosphate binder. Sevelamer helps prevent hypocalcemia (low levels of calcium in the body) caused by elevated phosphorus. Sevelamer is used to control phosphorus levels in people with chronic kidney disease who are on dialysis. Sevelamer may also be used for purposes not listed in this medication guide. You should not take sevelamer if you have a bowel obstruction. You should not take sevelamer if you are allergic to it, or if you have a bowel obstruction. To make sure sevelamer is safe for you, tell your doctor if you have: Learn more

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Sevelamer Carbonate Side Effects

For the Consumer

Applies to sevelamer: oral powder for suspension, oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, sevelamer may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sevelamer:

Incidence not known

  • Bloody, black, or tarry stools
  • heartburn
  • indigestion
  • nausea
  • severe abdominal or stomach pain, cramping, or burning
  • severe constipation
  • severe vomiting
  • trouble with breathing
  • vomiting
  • vomiting of material that looks like coffee grounds, severe and continuing
Side effects not requiring immediate medical attention

Some side effects of sevelamer may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • belching
  • bloating
  • constipation
  • diarrhea
  • excess air or gas in the stomach or intestines
  • full feeling
  • passing gas
  • stomach discomfort or upset

Incidence not known

  • Itching skin
  • rash

For Healthcare Professionals

Applies to sevelamer: oral capsule, oral powder for reconstitution, oral tablet

General

The most frequently occurring adverse reactions included nausea, vomiting, diarrhea, dyspepsia, abdominal pain, flatulence, and constipation.

Gastrointestinal

Gastrointestinal events are the most common adverse reactions reported with this drug. Based on studies of 8 to 52 weeks, the most common reason for drug withdrawal are gastrointestinal adverse reactions (3% to 16%).

Very common (10% or more): Vomiting (22%), nausea (20%), diarrhea (19%), dyspepsia (16%)

Common (1% to 10%): Abdominal pain, flatulence, constipation, gastrointestinal reflux disease

Frequency not reported: Dysphagia, diverticulitis

Postmarketing reports: Fecal impaction, ileus, intestinal obstruction, intestinal perforation

Immunologic

Common (1% to 10%): Peritonitis

A clinical study in patients receiving peritoneal dialysis (n=143) found the most frequently occurring treatment emergent serious adverse reaction was peritonitis. Peritonitis occurred in 8 patients receiving sevelamer and 2 patients on active control.

Metabolic

Common (1% to 10%): Anorexia

Uncommon (0.1% to 1%): Acidosis, increased serum chloride levels, decreased carbon dioxide

Hypersensitivity

Postmarketing reports: Hypersensitivity

Respiratory

Very common (10% or more): Nasopharyngitis, bronchitis

Common (1% to 10%): Cough, upper respiratory tract infection, dyspnea

Dermatologic

Postmarketing reports: Pruritus, rash

Genitourinary

Common (1% to 10%): Urinary tract infection

Cardiovascular

Common (1% to 10%): Hypertension

Local

Common (1% to 10%): Arteriovenous fistula site complication, arteriovenous fistula site hemorrhage, arteriovenous fistula thrombosis

Nervous system

Common (1% to 10%): Dizziness, headache

Other

Common (1% to 10%): Fatigue, fever

Musculoskeletal

Common (1% to 10%): Arthralgia, muscle spasms, extremity pain

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Sevelamer Carbonate (www.drugs.com/mtm/sevelamer.html).