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Sensorcaine-mpf Prescription
Generic Name: Bupivacaine (byoo PIV a kane)
Brand Name: Bupivacaine Fisiopharma, Bupivacaine Spinal, Marcaine, Marcaine Preservative Free, Marcaine Spinal, ...show all 10 brand names.
Easy-to-read patient leaflet for Sensorcaine-MPF. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Sensorcaine-mpf Drug Information:

This is not a list of all drugs or health problems that interact with Sensorcaine-MPF (bupivacaine). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Sensorcaine-MPF (bupivacaine) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. For all uses of Sensorcaine-MPF (bupivacaine): Learn more

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Sensorcaine-mpf Side Effects

Note: This document contains side effect information about bupivacaine. Some of the dosage forms listed on this page may not apply to the brand name Sensorcaine-MPF.

For the Consumer

Applies to bupivacaine: injection solution


Injection route (Solution)

The 0.75% concentration of bupivacaine injection is not recommended for obstetrical anesthesia. Cardiac arrest with difficult resuscitation or death during use of bupivacaine for epidural anesthesia in obstetrical patients has been reported. The 0.75% concentration should be reserved for surgical procedures where a high degree of muscle relaxation and prolonged effect are necessary.

Along with its needed effects, bupivacaine (the active ingredient contained in Sensorcaine-MPF) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking bupivacaine:

Incidence not known

  • Anxiety
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • cold, clammy, pale skin
  • confusion
  • cough
  • difficulty swallowing
  • discouragement
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • excitement
  • fast or irregular heartbeat
  • feeling sad or empty
  • general feeling of illness
  • hives, itching, skin rash
  • inability to breathe without assistance
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • nausea
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • restlessness
  • seizures
  • severe headache
  • shivering
  • slow heart rate
  • slowing of labor
  • stiff neck or back
  • sweating
  • tightness in the chest
  • trouble concentrating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
  • weakness of the muscles in your face

Some side effects of bupivacaine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Abnormal ejaculation
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decrease in frequency and amount of urine
  • decreased sexual performance or desire
  • difficulty in passing urine [dribbling]
  • hearing loss
  • no sensation in the legs
  • numbness
  • painful urination
  • unable to move the legs

For Healthcare Professionals

Applies to bupivacaine: compounding powder, injectable kit, injectable solution, intrathecal solution, intravenous solution


The most frequently reported side effects are acute adverse experiences which demand immediate countermeasures are related to the central nervous system and the cardiovascular system. A major cause of adverse reactions is excessive plasma levels, which may be due to overdose, unintentional intravascular injection, or slow metabolic degradation. It is also difficult to distinguish adverse reactions caused by the drug per se from the physiological effects of the nerve block (e.g. decrease in blood pressure, bradycardia, temporary urinary retention), events caused directly (e.g. spinal hematoma) or indirectly (e.g. meningitis, epidural abscess) by needle puncture or events associated to cerebrospinal leakage (e.g. postdural puncture headache).


Very common (10% or more): Hypotension, bradycardia

Common (1% to 10%): Hypertension

Rare (less than 0.1%): Cardiac arrest, cardiac arrhythmia

Frequency not reported: Cardiac output decreased, heart block, ventricular tachycardia, ventricular fibrillation, myocardium depression, cardiovascular collapse, maternal hypotension

Nervous system

Common (1% to 10%): Paresthesia, postdural puncture headache, dizziness

Uncommon (0.1% to 1%): Paresis, dysesthesia, convulsion, circumoral paresthesia, unconsciousness, tremor, lightheadedness, dysarthria

Rare (less than 0.1%): Paraplegia, paralysis, neuropathy, arachnoiditis, total unintentional spinal block, peripheral nerve injury

Frequency not reported: Loss of sphincter control, meningismus, cranial nerve palsies, syncope, high/total spinal block, slurred speech, drowsiness, spinal hematoma


Very common (10% or more): Nausea

Common (1% to 10%): Vomiting

Frequency not reported: Fecal incontinence, swallowing difficult, numbness of tongue


Frequency not reported: Persistent anesthesia


Common (1% to 10%): Urinary retention, urinary incontinence

Frequency not reported: Loss of perineal sensation, loss of sexual function


Rare (less than 0.1%): Respiratory depression

Frequency not reported: Respiratory arrest, laryngeal edema, sneezing, respiratory paralysis, hypoxia, hypercarbia


Uncommon (0.1% to 1%): Hyperacusis, tinnitus

Frequency not reported: Alkaline phosphatase increased, bilirubin increased, chills, weakness, septic meningitis, labor delayed, temperature elevated, forceps delivery increased, sensation of heat, cold/numbness


Rare (less than 0.1%): Allergic reaction, anaphylactic shock

Frequency not reported: Anaphylaxis


Uncommon (0.1% to 1%): Vision disturbed

Rare (less than 0.1%): Diplopia

Frequency not reported: Blurred vision, pupils constricted


Frequency not reported: Restlessness, anxiety, depression, agitation, nervousness, apprehension, euphoria, confusion


Frequency not reported: Hepatic dysfunction, ALT increased, AST increased


Frequency not reported: Urticaria, pruritus, erythema, angioedema, excessive sweating, cutaneous lesion


Uncommon (0.1% to 1%): Muscle weakness, back pain, muscle twitching

Frequency not reported: Joint pain, stiffness, loss of motion

Postmarketing reports: Chondrolysis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Sensorcaine-mpf (www.drugs.com/cdi/sensorcaine-mpf.html).