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Semprex-d Prescription
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Generic Name: acrivastine and pseudoephedrine (a KRIV a steen and SOO doe ee FED rin)
Brand Name: Semprex-D
Physician reviewed Semprex-D patient information - includes Semprex-D description, dosage and directions.
Generic Name: acrivastine and pseudoephedrine (a KRIV a steen and SOO doe ee FED rin)
Brand Name: Semprex-D
Physician reviewed Semprex-D patient information - includes Semprex-D description, dosage and directions.
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1 tablets of Semprex-d 40 mg
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Semprex-d Drug Information:

Semprex-D is a combination medicine used to treat runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies. Semprex-D may also be used for purposes not listed in this medication guide. You should not use Semprex-D if you have severe or uncontrolled high blood pressure or coronary artery disease. Do not use Semprex-D if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, Linezolid, Methylene Blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Learn more

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Semprex-d Side Effects

Note: This document contains side effect information about acrivastine / pseudoephedrine. Some of the dosage forms listed on this page may not apply to the brand name Semprex-D.

In Summary

Common side effects of Semprex-D include: dizziness and drowsiness. Other side effects include: insomnia, sedated state, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to acrivastine/pseudoephedrine: oral capsule

Along with its needed effects, acrivastine / pseudoephedrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Get emergency help immediately if any of the following symptoms of overdose occur while taking acrivastine / pseudoephedrine:

Symptoms of overdose

  • Blurred vision
  • chest pain or discomfort
  • cold, clammy, or pale skin
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • irregular heartbeats
  • seizures
  • shortness of breath
  • slow heart rate
  • sweating
  • unusual tiredness or weakness

Some side effects of acrivastine / pseudoephedrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Dry mouth
  • headache
  • sleepiness or unusual drowsiness

Less common

  • Acid or sour stomach
  • belching
  • body aches or pain
  • congestion
  • cough
  • dryness or soreness of the throat
  • fever
  • heartburn
  • hoarseness
  • indigestion
  • lack or loss of strength
  • nausea
  • nervousness
  • runny nose
  • stomach discomfort, upset, or pain
  • tender, swollen glands in the neck
  • trouble sleeping
  • trouble swallowing
  • voice changes

For Healthcare Professionals

Applies to acrivastine / pseudoephedrine: oral capsule

Nervous system

Very common (10% or more): Headache (19%), somnolence (12%)

Common (1% to 10%): Dizziness


Common (1% to 10%): Dry mouth, nausea, dyspepsia


Postmarketing reports: Serious hypersensitivity reactions (anaphylaxis, angioedema, bronchospasm, erythema multiforme)


Common (1% to 10%): Insomnia, nervousness


Common (1% to 10%): Dysmenorrhea


Common (1% to 10%): Pharyngitis, cough increase


Common (1% to 10%): Asthenia

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Semprex-d (www.drugs.com/mtm/semprex-d.html).