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Salsalate is a non-steroidal anti-inflammatory drug (NSAID) in a group of drugs called salicylates (sa-LIS-il-ates).
Salsalate is used to reduce pain, swelling, and joint stiffness caused by rheumatoid arthritis, osteoarthritis, or rheumatic disorder.
Salsalate may also be used for purposes not listed in this medication guide.
You should not use salsalate if you have severe kidney disease, or if you have ever had a severe allergic reaction after taking aspirin, an NSAID (nonsteroidal anti-inflammatory drug), or other salicylates.
Salsalate can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Salsalate may also cause stomach or intestinal bleeding, which can be fatal.
Salsalate can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Salsalate may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using salsalate, especially in older adults.
You should not use salsalate if you are allergic to it, or if you have:
severe kidney disease; or
a history of severe allergic reaction after taking aspirin, an NSAID, or other salicylates.
Do not take this medicine if you have a fever, flu symptoms, or chickenpox. Salicylates can cause Reye's syndrome, a serious and sometimes fatal condition, if you have any of these conditions.
Tell your doctor if you have ever had:
heart disease, high blood pressure, congestive heart failure;
a stroke or heart attack;
swelling or fluid retention;
a stomach ulcer;
bleeding in your stomach or intestines;
liver or kidney disease;
asthma; or
a bleeding or blood clotting disorder.
Taking salsalate during late pregnancy may harm the unborn baby, and may cause bleeding in the mother or the baby during delivery. Tell your doctor if you are pregnant or plan to become pregnant.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
Older adults may be more sensitive to the effects of this medicine.
Follow all directions on your prescription label and read all medication guides. Use the lowest dose that is effective in treating your condition.
It may take up to 4 days before you receive the full benefit of taking salsalate. Your doctor will determine how long to treat you with salsalate.
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using salsalate.
If you need surgery, dental work, or a medical procedure, tell your healthcare professional you currently use this medicine. You may need to stop for a short time.
If you use this medicine long-term, you may need frequent medical tests.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Since salsalate is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include ringing in your ears, headache, confusion, severe dizziness or drowsiness, sweating, fast breathing, severe vomiting or diarrhea.
Avoid alcohol. Heavy drinking can increase your risk of stomach bleeding.
Ask a doctor or pharmacist before taking other medicines that may contain a salicylate (such as aspirin, magnesium salicylate, choline salicylate, diflunisal, Ecotrin, Tricosal, Trilisate, and others).
Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to salsalate (such as aspirin, choline salicylate, or magnesium salicylate).
Avoid driving or hazardous activity until you know how salsalate will affect you. Your reactions could be impaired.
If you are also taking low-dose aspirin to prevent heart attack or stroke, do not stop taking it or change your dose without your doctor's advice. Aspirin should be used for cardiovascular conditions only under the supervision of a doctor.
Avoid smoking, since it can also increase your risk of stomach bleeding.
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Stop using salsalate and call your doctor at once if you have:
swelling in your hands or feet, rapid weight gain;
severe headache, blurred vision, pounding in your neck or ears;
pale skin, unusual tiredness, cold hands and feet;
liver problems--nausea, stomach pain (upper right side), tiredness, itching, jaundice (yellowing of the skin or eyes);
signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; or
signs of a stroke--sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, balance problems.
Older adults may be more likely to have side effects from salsalate.
Common side effects may include:
nausea;
hearing problems;
a spinning sensation;
rash; or
abnormal liver function tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Osteoarthritis:
3000 mg orally per day in 2 or 3 divided doses
Comments:
-Lower doses may be necessary to achieve therapeutic blood concentration and to avoid more common side effects (e.g., auditory effects).
-Alleviation of symptoms is gradual and full benefit may not be achieved for 3 to 4 days.
Uses: For the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, and related rheumatic disorder
Usual Adult Dose for Rheumatoid Arthritis:
3000 mg orally per day in 2 or 3 divided doses
Comments:
-Lower doses may be necessary to achieve therapeutic blood concentration and to avoid more common side effects (e.g., auditory effects).
-Alleviation of symptoms is gradual and full benefit may not be achieved for 3 to 4 days.
Uses: For the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, and related rheumatic disorder
Tell your doctor about all your current medicines. Many drugs can affect salsalate, especially:
lithium;
methotrexate;
naproxen;
phenytoin;
penicillin;
a diuretic or "water pill";
oral diabetes medicine;
heart or blood pressure medication--benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril;
a blood thinner--warfarin, Coumadin, Jantoven; or
steroid medicine--prednisone, dexamethasone, methylprednisolone, and others.
This list is not complete and many other drugs may affect salsalate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Further informationRemember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Salsalate (www.drugs.com/mtm/salsalate.html).
Applies to salsalate: oral tablets
Side effects include:
Tinnitus, nausea, hearing impairment, rash, vertigo.
For Healthcare ProfessionalsApplies to salsalate: oral capsule, oral tablet
GeneralThe most frequently reported side effects were usually reversible and included tinnitus, nausea, hearing impairment, rash, and vertigo.
GastrointestinalFrequency not reported: Nausea, abdominal pain, diarrhea, gastrointestinal bleeding
CardiovascularFrequency not reported: Hypotension
DermatologicFrequency not reported: Rash, angioedema, urticaria
HepaticFrequency not reported: Hepatic function abnormal, hepatitis
RenalFrequency not reported: Nephritis
RespiratoryFrequency not reported: Bronchospasm
OtherFrequency not reported: Tinnitus, hearing impaired, vertigo, creatinine clearance decreased
ImmunologicFrequency not reported: Anaphylactic shock
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Salsalate (www.drugs.com/mtm/salsalate.html).
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