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Salsalate Prescription
Generic Name: salsalate (SAL sa late)
Brand Name: Disalcid, Salflex, ...show all 8 brand names.
Physician reviewed salsalate patient information - includes salsalate description, dosage and directions.
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Salsalate Drug Information:

Salsalate is a non-steroidal anti-inflammatory drug (NSAID) in a group of drugs called salicylates (sa-LIS-il-ates). Salsalate is used to reduce pain, swelling, and joint stiffness caused by rheumatoid arthritis, osteoarthritis, or rheumatic disorder. Salsalate may also be used for purposes not listed in this medication guide. You should not use salsalate if you have severe kidney disease, or if you have ever had a severe allergic reaction after taking Aspirin, an NSAID (nonsteroidal anti-inflammatory drug), or other salicylates. Learn more

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Salsalate Side Effects

For the Consumer

Applies to salsalate: oral tablets


    Cardiovascular Risk
  • Possible increased risk of serious (sometimes fatal) cardiovascular thrombotic events (e.g., MI, stroke). Risk may increase with duration of use. Individuals with cardiovascular disease or risk factors for cardiovascular disease may be at increased risk. (See Cardiovascular Effects under Cautions.)

  • Contraindicated for the treatment of pain in the setting of CABG surgery.

    GI Risk
  • Increased risk of serious (sometimes fatal) GI events (e.g., bleeding, ulceration, perforation of the stomach or intestine). Serious GI events can occur at any time and may not be preceded by warning signs and symptoms. Geriatric individuals are at greater risk for serious GI events. (See GI Effects under Cautions.)

Side effects include:

Tinnitus, nausea, hearing impairment, rash, vertigo.

For Healthcare Professionals

Applies to salsalate: oral capsule, oral tablet


The most frequently reported side effects were usually reversible and included tinnitus, nausea, hearing impairment, rash, and vertigo.


Frequency not reported: Nausea, abdominal pain, diarrhea, gastrointestinal bleeding


Frequency not reported: Hypotension


Frequency not reported: Rash, angioedema, urticaria


Frequency not reported: Hepatic function abnormal, hepatitis


Frequency not reported: Nephritis


Frequency not reported: Bronchospasm


Frequency not reported: Tinnitus, hearing impaired, vertigo, creatinine clearance decreased


Frequency not reported: Anaphylactic shock

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Salsalate (www.drugs.com/mtm/salsalate.html).