Please wait...


Generic Name: riluzole (RIL yoo zol)
Brand Name: Rilutek, Tiglutik
Physician reviewed riluzole patient information - includes riluzole description, dosage and directions.
  • Prescription Settings
  • X
  • Local Pharmacy Pickup available at . Pick up your medication at any of our participating pharmacies.
  • Mail Order Home Delivery available at , the easiest way to receive your medications.
  • Learn more

Riluzole Coupons & Prices

Set your location
for drug prices near you

Enter your zip code

Please wait while the prices are loaded...
Click here to try again.

Don’t see your pharmacy listed? Most pharmacies accept our discounts, so have your pharmacist enter this coupon to see if you will save money:

Drug Information:
Riluzole is used to treat amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig's disease. Riluzole is not a cure for ALS, but it may delay progression of the disease and prolong your life. Riluzole may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare prOviders about all your medical conditions, allergies, and all medicines you use. You should not use riluzole if you are allergic to it. Riluzole is not approved for use by anyone younger than 18 years old. Learn more

Buy Riluzole online and Riluzole delivery

USARx offers multiple ways to purchase this medication. Choose the Best option for you!

  • Guaranteed Price
    Local Pharmacy Pickup

    Pay this amount and pick up your prescription at ANY Retail pharmacy of your choice! Walgreens, CVS, Walmart, etc.

  • 30-day supply
    90-day supply
    Mail Order Home Delivery

    The easiest way to receive your medications.

Riluzole Side Effects

In Summary

Commonly reported side effects of riluzole include: asthenia, nausea, and increased serum alanine aminotransferase. Other side effects include: vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to riluzole: oral suspension, oral tablet

Along with its needed effects, riluzole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking riluzole:

Less common

  • Bladder pain
  • bloody or cloudy urine
  • blurred vision
  • chills
  • cough
  • dark urine
  • diarrhea
  • difficult, burning, or painful urination
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • headache
  • increased cough
  • itching skin
  • joint pain
  • loss of appetite
  • lower back or side pain
  • muscle aches and pains
  • nausea
  • nervousness
  • persistent loss of appetite or weight loss
  • pounding in the ears
  • right upper quadrant tenderness
  • runny nose
  • shivering
  • slow heartbeat
  • sore throat
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
  • yellow eyes or skin

Incidence not known

  • Black, tarry, stools
  • decreased frequency or amount of urine
  • difficult breathing
  • increased thirst
  • nausea
  • pale skin
  • swelling of the face, fingers, or lower legs
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • weight gain

Some side effects of riluzole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Lack or loss of strength

Less common

  • Difficulty moving
  • dizziness or lightheadedness
  • dry mouth
  • excess air or gas in the stomach or bowels
  • feeling of constant movement of self or surroundings
  • full feeling
  • muscle stiffness
  • passing gas
  • rapid weight gain
  • sensation of spinning
  • skin rash, encrusted, scaly and oozing
  • sleepiness or unusual drowsiness
  • stomach pain
  • tingling of the hands or feet
  • unusual weight gain or loss

For Healthcare Professionals

Applies to riluzole: oral suspension, oral tablet


The most commonly reported adverse reactions have included asthenia, nausea, dizziness, decreased lung function, and abdominal pain.


In clinical trials, ALT elevations above 5 times the upper limit of normal (5 X ULN) were reported in 2% of patients, about 50% had at least 1 elevated ALT, and 8% had at least one elevated ALT level above 3 x ULN. Drug-induced hepatic injury, including fatalities, have been reported.

Study data indicate that Asian patients may be more susceptible to liver function test abnormalities; 3.2% (194/5995) of Asian patients and 1.8% (100/5641) of Caucasian patients experienced liver function test abnormalities.

Very common (10% or more): At least 1 ALT elevation of above upper limit of normal (ULN)

Common (1% to 10%): ALT elevation above 5 x ULN

Rare (0.01% to 0.1%): Hepatitis, jaundice, hepatocellular damage

Frequency not reported: Drug-induced hepatic injury

Postmarketing reports: Acute hepatitis and icteric toxic hepatitis


Uncommon (0.1% to 1%): Anemia

Rare (0.01% to 0.1%): Erythropenia, leucopenia, thrombocytopenia

Very rare (less than 0.01%): Neutropenia

There have been 3 reports (n=5000) of marked neutropenia where absolute neutrophil count was less than 500/mm3, all within first 2 months of treatment. In one case, neutrophil counts rose on continued treatment. In a second case, counts rose after therapy was stopped. A third case was associated with marked anemia with uncertain etiology


Common (1% to 10%): Decreased lung function, increased cough,

Uncommon (0.1% to 1%): Respiratory failure, interstitial lung disease

Rare (0.01% to 0.1%): Asphyxia, respiratory distress.

Frequency not reported: Hypersensitivity pneumonitis


Very common (10% or more): Nausea (16%)

Common (1% to 10%): Abdominal pain, vomiting, dry mouth, flatulence

Uncommon (0.1% to 1%): Pancreatitis

Rare (0.01% to 0.1%): Gastrointestinal disorder, gastric ulcer, gastrointestinal hemorrhage, gastrointestinal irritation, melena

Nervous system

Common (1% to 10%): Dizziness, circumoral paresthesia, somnolence

In clinical trials, the incidence of dizziness was greater in females than males (11% vs 4%). There was no difference in rates of adverse reactions leading to discontinuation between genders.


Very rare (less than 0.01%): Angioedema

Frequency not reported: Anaphylaxis


Common (1% to 10%): Insomnia

Rare (0.01% to 0.1%): Completed suicide, confusion, delirium, hallucination, personality change due to a general medical condition

Very rare (less than 0.01%): Amnesia


Postmarketing reports: Renal tubular impairment


Common (1% to 10%): Arthralgia


Common (1% to 10%): Hypertension, tachycardia, peripheral edema

Rare (0.01% to 0.1%): Angina unstable, atrial fibrillation, cardiac failure

Very rare (less than 0.01%): Arrhythmia


Rare (0.01% to 0.1%): Dehydration

Very rare (less than 0.01%): Hyponatremia


Very common (10% or more): Asthenia (19%)

Common (1% to 10%): Vertigo, malaise, pyrexia


Common (1% to 10%): Pruritus, eczema

Rare (0.01% to 0.1%): Dermatitis


Common (1% to 10%): Urinary tract infection

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Riluzole (www.drugs.com/mtm/riluzole.html).