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Applies to rifampin: oral capsule
Other dosage forms:
Along with its needed effects, rifampin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking rifampin:
Rare
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking rifampin:
Symptoms of overdose
Some side effects of rifampin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Rare
Incidence not known
For Healthcare Professionals
Applies to rifampin: compounding powder, intravenous powder for injection, oral capsule
DermatologicUncommon (0.1% to 1%): Serious cutaneous reactions
Frequency not reported: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, erythema multiforme, face edema, itching with/without rash, mild cutaneous reactions, pemphigoid reaction, pruritus, rash, self-limiting cutaneous reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria
HypersensitivityUncommon (0.1% to 1%): Hypersensitivity reactions
Rare (0.01% to 0.1%): Anaphylaxis
Hypersensitivity reactions included acute renal failure, acute tubular necrosis, hematuria, hemoglobinuria, hemolysis, interstitial nephritis, renal insufficiency, and serious cutaneous reactions.
RenalRare (0.01% to 0.1%): Acute renal failure, acute tubular necrosis, interstitial nephritis, renal insufficiency
Frequency not reported: Blood urea nitrogen elevations
Acute renal failure, acute tubular necrosis, interstitial necrosis, renal insufficiency were hypersensitivity reactions and usually occurred during intermittent therapy or during the resumption of intentional/accidental interruption of a daily dosage regimen. The effects were usually reversible when treatment was discontinued and appropriate therapy was instituted.
HematologicRare (0.01% to 0.1%): Disseminated intravascular coagulation, hemolysis, thrombocytopenia
Very rare (less than 0.01%): Agranulocytosis
Frequency not reported: Decreased hemoglobin, eosinophilia, hemolytic anemia, leukopenia
Thrombocytopenia usually occurred with high-dose intermittent therapy, but has occurred with well-supervised daily therapy and after resumption of interrupted treatment; the effect is reversible if treatment is discontinued as soon as purpura occurs.
Hemolysis was a hypersensitivity reaction and usually occurred during intermittent therapy or during the resumption of intentional/accidental interruption of a daily dosage regimen. This effect was usually reversible when treatment was discontinued and appropriate therapy was instituted.
HepaticRare (0.01% to 0.1%): Abnormal liver function tests, hepatitis, shock-like syndrome with hepatic involvement
Frequency not reported: Jaundice, transient liver function test abnormalities, serum bilirubin elevations, serum transaminase elevations
GenitourinaryHematuria and hemoglobinuria were hypersensitivity reactions and usually occurred during intermittent therapy or during the resumption of intentional/accidental interruption of a daily dosage regimen. The effects were usually reversible when treatment was discontinued and appropriate therapy was instituted.
Rare (0.01% to 0.1%): Hematuria, hemoglobinuria
Frequency not reported: Menstrual disturbances
MusculoskeletalRare (0.01% to 0.1%): Myopathy
Frequency not reported: Bone pain, extremity pain, muscular weakness
Bone pain was included in flu syndrome, and occurred in patients receiving intermittent regimens; however, this event may occur in patients taking this drug irregularly or if daily administration is resumed after a drug-free interval.
PsychiatricRare (0.01% to 0.1%): Psychoses
Frequency not reported: Behavioral changes, mental confusion
EndocrineRare (0.01% to 0.1%): Adrenal insufficiency
Adrenal insufficiency occurred in patients with compromised adrenal function.
GastrointestinalFrequency not reported: Cramps, diarrhea, epigastric distress, flatulence, heartburn, nausea, pseudomembranous colitis, sore mouth, sore tongue, tooth discoloration/permanent tooth discoloration, vomiting
Nervous systemCerebral hemorrhage occurred in patients who continued or resumed treatment after the appearance of purpura.
Dizziness and headache were included in flu syndrome, and occurred in patients receiving intermittent regimens; however, the events may occur in patients taking this drug irregularly or if daily administration is resumed after a drug-free interval.
Frequency not reported: Ataxia, cerebral hemorrhage, dizziness, drowsiness, generalized numbness, headache, inability to concentrate
CardiovascularFrequency not reported: Decreased blood pressure, extremity edema, flushing with/without rash, shock, vasculitis
Decreased blood pressure and shock were included in flu syndrome, and occurred in patients receiving intermittent regimens; however, the events may occur in patients taking this drug irregularly or if daily administration is resumed after a drug-free interval.
OtherFrequency not reported: Chills, fatalities, fatigue, fever
Chills and fever were included in flu syndrome, and occurred in patients receiving intermittent regimens; however, the events may occur in patients taking this drug irregularly or if daily administration is resumed after a drug-free interval.
Fatalities occurred in patients who continued or resumed treatment after the appearance of purpura.
MetabolicFrequency not reported: Alkaline phosphatase elevations, anorexia, serum uric acid elevations
OcularFrequency not reported: Conjunctivitis, visual disturbances
ImmunologicFlu syndrome occurred in patients receiving intermittent regimens, but may occur in patients taking this drug irregularly or if daily administration is resumed after a drug-free interval.
Frequency not reported: Flu syndrome
RespiratoryFrequency not reported: Shortness of breath, wheezing
Shortness of breath and wheezing were included in flu syndrome, and occurred in patients receiving intermittent regimens; however, the events may occur in patients taking this drug irregularly or if daily administration is resumed after a drug-free interval.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Rifampin (www.drugs.com/mtm/rifampin.html).
August 29, 2021
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