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Rifabutin Prescription
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Generic Name: rifabutin (RIF a BUE tin)
Brand Name: Mycobutin
Physician reviewed rifabutin patient information - includes rifabutin description, dosage and directions.
Generic Name: rifabutin (RIF a BUE tin)
Brand Name: Mycobutin
Physician reviewed rifabutin patient information - includes rifabutin description, dosage and directions.
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30 tablets of Rifabutin 40 mg
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Rifabutin Drug Information:

Rifabutin is an antibiotic that fights bacteria. Rifabutin is used to prevent mycobacterium avium complex (MAC) in people with HIV (human immunodeficiency virus) infection. Rifabutin is also used with other medicines to treat tuberculosis in people with HIV. Rifabutin may also be used for purposes not listed in this medication guide. You should not use rifabutin if you have active tuberculosis, or if you are also taking delavirdine or Voriconazole. You should not use rifabutin if you are allergic to it, or if you have: Learn more

Rifabutin Side Effects

In Summary

Commonly reported side effects of rifabutin include: neutropenia and urine discoloration. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to rifabutin: oral capsule

Along with its needed effects, rifabutin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rifabutin:

More common

  • Black, tarry stools
  • chest pain
  • chills
  • cough
  • diarrhea
  • fever
  • heartburn
  • indigestion
  • itching or skin rash
  • loss of appetite
  • painful or difficult urination
  • sore throat
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Loss of strength or energy
  • muscle pain


  • Bruising or purple spots on the skin
  • change in taste
  • eye pain
  • joint pain
  • loss of vision
  • lower back or side pain
  • muscle swelling or pain
  • pale skin
  • yellow skin

Some side effects of rifabutin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain
  • bad, unusual, or unpleasant (after) taste in the mouth
  • belching
  • bloated or full feeling
  • change in taste
  • discoloration of the urine
  • excess air or gas in the stomach or intestines
  • headache
  • nausea
  • passing gas
  • trouble sleeping

For Healthcare Professionals

Applies to rifabutin: oral capsule


The most commonly reported side effects included discolored urine, neutropenia, leukopenia, and jaundice.


Very common (10% or more): Discolored urine (up to 30%)


The frequency and severity of hematological side effects may be increased with concomitant isoniazid use.

Very common (10% or more): Neutropenia (up to 25%), leukopenia (up to 17%)

Common (1% to 10%): Anemia, eosinophilia, thrombocytopenia

Uncommon (0.1% to 1%): Agranulocytosis, granulocytopenia, lymphopenia, neutrophil count decreased, pancytopenia, platelet count decreased, white blood cell count decreased

Frequency not reported: hemolysis, thrombotic thrombocytopenic purpura, white blood cell disorder


Very common (10% or more): Jaundice (up to 12%)

Common (1% to 10%): Increased alkaline phosphatase, increased ALT, increased AST

Uncommon (0.1% to 1%): Hepatic enzymes increased

Frequency not reported: Hepatitis


Very common (10% or more): Rash (up to 11%)

Uncommon (0.1% to 1%): Skin discoloration

Postmarketing reports: Urticaria


Common (1% to 10%): Abdominal pain, diarrhea, dyspepsia, eructation, flatulence, gastrointestinal intolerance, nausea, nausea and vomiting, vomiting

Frequency not reported: Clostridium difficile colitis

Postmarketing reports: C difficile-associated diarrhea


Common (1% to 10%): Asthenia, fever, pain, pyrexia

Nervous system

Common (1% to 10%): Headache, taste perversion

Frequency not reported: aphasia, paresthesia, seizure


Common (1% to 10%): Myalgia

Uncommon (0.1% to 1%): Arthralgia

Frequency not reported: Myositis

Generalized arthralgia occurred in patients given 1050 to 2400 mg/day; symptoms abated when treatment was discontinued.


Common (1% to 10%): Chest pain

Frequency not reported: Chest pressure, nonspecific T wave changes (on ECG), shock

Postmarketing reports: Hypotension


Common (1% to 10%): Insomnia

Frequency not reported: Confusion


Common (1% to 10%): Anorexia


Uncommon (0.1% to 1%): Hypersensitivity, other hypersensitivity reactions

Frequency not reported: Anaphylactic shock

Postmarketing reports: Angioedema


Uncommon (0.1% to 1%): Corneal deposits, uveitis

Postmarketing reports: Conjunctivitis

Uveitis occurred in patients given 1050 to 2400 mg/day; symptoms abated when treatment was discontinued.

Uveitis was rare when this drug was used as a single agent at 300 mg/day, or in combination with fluconazole and/or macrolides (e.g., clarithromycin). However, the incidence of uveitis was greater if higher doses of this drug were used with these agents. Patients who developed uveitis had mild to severe symptoms that resolved following therapy with corticosteroids and/or mydriatic eye drops; however, in some severe cases, resolution of symptoms occurred after several weeks.


Uncommon (0.1% to 1%): Bronchospasm

Frequency not reported: Dyspnea


Frequency not reported: Flu-like syndrome

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Rifabutin (www.drugs.com/mtm/rifabutin.html).