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Commonly reported side effects of rifabutin include: neutropenia and urine discoloration. See below for a comprehensive list of adverse effects.
Applies to rifabutin: oral capsule
Along with its needed effects, rifabutin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking rifabutin:
Some side effects of rifabutin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to rifabutin: oral capsule
The most commonly reported side effects included discolored urine, neutropenia, leukopenia, and jaundice.
Very common (10% or more): Discolored urine (up to 30%)
The frequency and severity of hematological side effects may be increased with concomitant isoniazid use.
Very common (10% or more): Neutropenia (up to 25%), leukopenia (up to 17%)
Common (1% to 10%): Anemia, eosinophilia, thrombocytopenia
Uncommon (0.1% to 1%): Agranulocytosis, granulocytopenia, lymphopenia, neutrophil count decreased, pancytopenia, platelet count decreased, white blood cell count decreased
Frequency not reported: hemolysis, thrombotic thrombocytopenic purpura, white blood cell disorder
Very common (10% or more): Jaundice (up to 12%)
Common (1% to 10%): Increased alkaline phosphatase, increased ALT, increased AST
Uncommon (0.1% to 1%): Hepatic enzymes increased
Frequency not reported: Hepatitis
Very common (10% or more): Rash (up to 11%)
Uncommon (0.1% to 1%): Skin discoloration
Postmarketing reports: Urticaria
Common (1% to 10%): Abdominal pain, diarrhea, dyspepsia, eructation, flatulence, gastrointestinal intolerance, nausea, nausea and vomiting, vomiting
Frequency not reported: Clostridium difficile colitis
Postmarketing reports: C difficile-associated diarrhea
Common (1% to 10%): Asthenia, fever, pain, pyrexia
Common (1% to 10%): Headache, taste perversion
Frequency not reported: aphasia, paresthesia, seizure
Common (1% to 10%): Myalgia
Uncommon (0.1% to 1%): Arthralgia
Frequency not reported: Myositis
Generalized arthralgia occurred in patients given 1050 to 2400 mg/day; symptoms abated when treatment was discontinued.
Common (1% to 10%): Chest pain
Frequency not reported: Chest pressure, nonspecific T wave changes (on ECG), shock
Postmarketing reports: Hypotension
Common (1% to 10%): Insomnia
Frequency not reported: Confusion
Common (1% to 10%): Anorexia
Uncommon (0.1% to 1%): Hypersensitivity, other hypersensitivity reactions
Frequency not reported: Anaphylactic shock
Postmarketing reports: Angioedema
Uncommon (0.1% to 1%): Corneal deposits, uveitis
Postmarketing reports: Conjunctivitis
Uveitis occurred in patients given 1050 to 2400 mg/day; symptoms abated when treatment was discontinued.
Uveitis was rare when this drug was used as a single agent at 300 mg/day, or in combination with fluconazole and/or macrolides (e.g., clarithromycin). However, the incidence of uveitis was greater if higher doses of this drug were used with these agents. Patients who developed uveitis had mild to severe symptoms that resolved following therapy with corticosteroids and/or mydriatic eye drops; however, in some severe cases, resolution of symptoms occurred after several weeks.
Uncommon (0.1% to 1%): Bronchospasm
Frequency not reported: Dyspnea
Frequency not reported: Flu-like syndrome
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